Abstract：
:To minimize the incidence of postoperative infections in patients undergoing open-heart surgery, antibiotics should maintain tissue concentrations greater than the minimal inhibitory concentration (MIC) for potential pathogens (eg, Staphylococcus) for the duration of the operation. The ability of cefonicid, a new β-lactamase-resistant parenteral cephalosporin, to attain plasma and myocardial levels greater than the MIC (4.8 to 5.0 μg/mL) for penicillin-resistant Staphylococci was assessed in 13 patients. Six patients were administered 1 g and seven patients were administered 2 g of cefonicid IM one hour prior to surgery. In all patients the plasma concentrations of the drug were determined at the start of surgery, 15 minutes after the patient was placed on cardiopulmonary bypass (CPB), and at the completion of CPB. In addition, the concentration of cefonicid was determined in a right atrial biopsy. It was found that both 1 g and 2 g of cefonicid administered one hour prior to surgery resulted in plasma and myocardial levels greater than the MIC for the organisms most frequently implicated in postoperative infections.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Sterling RP,Connor DJ,Norman JCsubject
Has Abstractpub_date
1983-11-01 00:00:00pages
1075-80issue
11eissn
0027-9684issn
1943-4693journal_volume
75pub_type
杂志文章abstract：:Malaria continues to be a cause of high mortality and morbidity. Imported cases of malaria are increasing in New York City. Yet, New York physicians, when evaluating patients for fever, frequently missed the diagnosis of malaria. We evaluated the role of platelet count for predicting malarial infection. The study incl...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:Although mortality from cardiovascular diseases (CVDs) has been declining, it remains the leading cause of death among urban U.S. blacks. McCord and Freeman reported CVD as the major contributor to excess mortality in Central Harlem. However the disease-specific CVD mortality was not assessed. Thus, it was unclear wha...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：PURPOSE:Older African Americans may be vulnerable to risks due to impaired healthcare access and understudied complementary and alternative medicine (CAM) use and other traditions. We describe CAM use among older African Americans in Baltimore, MD, examining associations among CAM and sociodemographic, health status, h...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)31475-9
更新日期：2008-10-01 00:00:00
abstract：INTRODUCTION:This book review analyzes the complex and profound impact active religious participation has on relationships and family outcomes among African Americans and Latinos. In Soul Mates, Wilcox and Wolfinger discuss the legacy of slavery and Jim Crow laws and the resulting devastating effects on African America...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：10.1016/j.jnma.2016.08.007
更新日期：2016-01-01 00:00:00
abstract：:Testing of 722 black hospital patients in Baltimore for the Duffy antigens found in whites demonstrated that 36.28 percent of the patients possessed these blood proteins. This group is the largest cluster of black individuals so examined in the United States. The results may provide a genetic benchmark for the Baltimo...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
abstract：:Growth standards specific to black boys and girls are necessary because genetically determined patterns of growth in black children are significantly different from those of white children. Such standards have only recently become available, and they need further refinement. The required improvements include: (1) adju...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:In 1994, it was estimated that about 44,500 American women would die from breast cancer and 7000 women from cervical cancer. While early detection methods (screening mammography, breast examinations, and pap smears) have proven to be effective means of decreasing these cancers, they are underused by all groups. In par...
journal_title：Journal of the National Medical Association
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:In contrast to their white counterparts, black men in the United States live sicker and die younger. This longstanding phenomenon is sharply reflected in the poor international health status of black males. The NMA president discusses major health issues facing black males and posits a multidimensional strategy for ad...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-01 00:00:00
abstract：:Three open-label studies were conducted in which natural human interferon-alpha (nHuIFN-alpha) was given orally to human immunodeficiency virus (HIV)-infected patients at a daily dosage of 150 IU for 12 months in an attempt to assess the effects of this treatment on their CD4+ cell counts. In the first study, 110 pati...
journal_title：Journal of the National Medical Association
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:A retrospective descriptive study of older patients evaluated by the psychiatric emergency service (PES) of a general hospital was implemented. The medical records of all patients aged 65 years and older evaluated by the PES during the 1980 calendar year were reviewed. Seventy-four patients were identified, 38 male an...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Opioid use disorder (OUD) constitutes a significant public health burden as opioid overdose deaths have continued to rise in the United States. Although treatment modalities are available to manage OUD, some patients experience challenges achieving their OUD management goals. Some of these challenges may be attributab...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2019.09.006
更新日期：2019-12-01 00:00:00
abstract：:Enlarged spleen without a clear-cut etiology, and believed to be related to malarial infestations, has been referred to as "tropical splenomegaly" and "cryptogenetic splenomegaly." Splenectomy performed in such cases after a failure of antimalarial therapy shows histopathologically, while some of these meet the criter...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
abstract：:Lung cancer is the leading cause of cancer-related mortality. Nonsmall-cell lung cancer (NSCLC) constitutes approximately 80% of all the lung cancers observed. Despite the aggressive nature of this disease, totally adequate and fully comprehensive treatment yielding outstanding outcomes and survival has yet to be disc...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：10.1016/s0027-9684(15)31342-0
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Few studies have characterized ethnic variations in standard ophthalmic measures. We tested the hypothesis that nerve fiber layer thickness would show characteristic differences between white and black individuals. We also examined whether ophthalmic measures would show intraethnic differences. METHODS:Seve...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
abstract：:An hypothesis is proposed that there exists a subgroup of African-American hypertensive patients whose hypertension could have been prevented by the early detection and treatment of easily recognizable symptoms that signal the initiation of the pathophysiologic processes that lead to essential hypertension.A pilot stu...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND:Racial and ethnic disparities in mortality have been demonstrated in several diseases. African Americans are hospitalized at a significantly higher rate than whites for aspiration pneumonia; however, no studies have investigated racial and ethnic disparities in mortality in this population. OBJECTIVE:To ass...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:While African-American women tend to have greater bone mineral density (BMD) than caucasian women, they are still at risk of developing osteoporosis later in life. Clinical decision rules (i.e., algorithms) have been developed to assist clinicians identify women at greatest risk of low BMD. However, such tool...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:We present a case of multiple degloving injuries in an elderly man following a fall from a palm tree. Multiple midface injuries are very rare, although individual types have been reported. Our patient sustained injuries in the lower and middle thirds of the face, including multiple tongue lacerations and a deep jagged...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:Perineural and endoneural tumor spread is a form of metastatic disease in which the primary tumors spread along neural pathways and gain access to noncontiguous regions. Although rare, this type of skip metastasis into the cranial cavity occurs from tumors of the parotid gland and facial skin. Recognition of this proc...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Well-differentiated forms of thyroid cancer, including follicular carcinoma, usually have good prognoses. But they are also known to metastasize to the bones, lungs and central nervous system. Endobronchial metastasis is exceptionally rare. In this paper, we report on a patient with endobronchial metastasis of follicu...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:High sensitivity C-reactive protein (hsCRP) and Plasminogen Activator Inhibitor-1 (PAI-1) are recognised independent novel risk factors for cardiovascular disease. Few studies have assessed cardiovascular risk factors in patients with hyperglycaemic emergencies (HE), despite it being a major cause of death i...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2019.12.004
更新日期：2020-02-01 00:00:00
abstract：:Newly diagnosed insulin-dependent diabetic Nigerian Africans were studied prospectively over a 6-year period and were analyzed for sex, age at diagnosis, and month of onset of symptoms. Insulin-dependent diabetes mellitus (IDDM) rarely occurred in patients younger than the age of 10. A female preponderance occurred in...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Schistosomiasis is a common parasitic disease in the tropical and subtropical regions of Africa, Asia, South America and the Caribbean. It is the second most common parasitic infection of humans after malaria. Acute and chronic clinical presentations of S. monsoni are well described. Presentation as a pseudotumor is c...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：:This preliminary study explored the roles of knowledge, attitudes, and significant others on decisions of older African-American women to enroll in a clinical trial involving estrogen and osteoporosis. Sixteen older African-American women (average age 75 years) participated in three focus groups. Twelve of the women h...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：:Few recent data are available from formal evaluations of approved new drug applications to address perceptions that racial and ethnic groups are under-represented in clinical trials of new drugs. This study reviews racial and ethnic group participation in clinical trials and race-related labeling for new molecular ent...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：2001-12-01 00:00:00
abstract：PURPOSE:This article highlights issues of misdiagnosis in an African-American, adult clinical population by doing point prevalence, record review study within a comprehensive community mental health center. METHOD:Psychiatric evaluations of 330 patients were reviewed and clinically identifiable variables of: a) childh...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/S0027-9684(15)30048-1
更新日期：2015-03-01 00:00:00
abstract：:Patients with myasthenia gravis (MG) are too often misdiagnosed as having another disorder. Three patients are presented who were thought to have amyotrophic lateral sclerosis, velopharyngeal incompetence, and no diagnosis of MG, but actually each had myasthenia gravis. Their histories illustrate how the diagnosis of ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:In addition to well known parameters used for measuring in vitro cellular radiosensitivity (mean lethal dose, extrapolation number, quasithreshold dose), there are other, less well known measures that may be more important. The authors recently surveyed the literature and found that mean activation dose (D) has been n...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1989-07-01 00:00:00
abstract：OBJECTIVE:This study examined gender differences in how three social roles - marriage, parenthood, and employment - impact depressive symptoms and clinically significant depression for African Americans in the first decade of midlife, from 40 to 50 years old. Specifically, we sought to understand the associations betwe...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2018.10.012
更新日期：2019-06-01 00:00:00
abstract：:Sickle cell disease (SCD) is a hematological disorder that is manifested primarily by severe pain and chronic organ damage. Little normative data exists on what the usual healthcare utilization is of a population of SCD patients, especially adults. Our study analyzed the office, emergency department (ED) and hospital ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
