Abstract：
:Three open-label studies were conducted in which natural human interferon-alpha (nHuIFN-alpha) was given orally to human immunodeficiency virus (HIV)-infected patients at a daily dosage of 150 IU for 12 months in an attempt to assess the effects of this treatment on their CD4+ cell counts. In the first study, 110 patients received nHuIFN-alpha, and 142 patients received nHuIFN-alpha and azidothymidine (AZT). At 12 months, patients given nHuIFN-alpha alone had a mean increase of 14% in their CD4+ counts, although the mean increase in absolute CD4+ count was similar between the groups. Blacks in this study were more likely to experience an increase in CD4+ count than other ethnic groups (P < 0.001). In the second study, 40 black, male homosexuals with CD4+ count between 350 and 500/mm3 were enrolled in groups of 10 to receive either nHuIFN-alpha or AZT, or both nHuIFN-alpha and AZT, or nothing (untreated controls). At 12 months, the mean CD4+ counts of the patients in the group given nHuIFN-alpha alone were significantly higher than the mean CD4+ counts in both the group given AZT alone and the untreated controls (P < 0.01). In the third study, 38 patients with CD4+ cell counts > 700/mm3 were enrolled in groups of 19, matched by gender and ethnic group, to receive nHuIFN-alpha or nothing (untreated controls). Patients given nHuIFN-alpha experienced a mean increase of 12% in their CD4+ counts by the end of the 12-month study.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Jordan WCsubject
Has Abstractpub_date
1994-04-01 00:00:00pages
257-62issue
4eissn
0027-9684issn
1943-4693journal_volume
86pub_type
临床试验,杂志文章abstract：:Attributes of age, tobacco use, and alcohol consumption were studied in order to elucidate their roles in the increased risks of blacks for selected neoplasms. Black cancer patients with and without liver cirrhosis were compared by cancer sites, age, tobacco usage, and alcohol consumption. Subsequently, non-cirrhotic ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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doi：
更新日期：1989-07-01 00:00:00
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journal_title：Journal of the National Medical Association
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更新日期：1987-02-01 00:00:00
abstract：PURPOSE:We conducted a cross-sectional study examining potentially modifiable factors associated with cognitive impairments (mild or severe) in older whites, African Americans and Hispanics attending an outpatient eye clinic. METHODS:In-clinic interviews and physical examinations assessed social, demographic and healt...
journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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doi：
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
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journal_title：Journal of the National Medical Association
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更新日期：2002-06-01 00:00:00
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更新日期：1991-04-01 00:00:00
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journal_title：Journal of the National Medical Association
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更新日期：1989-06-01 00:00:00
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journal_title：Journal of the National Medical Association
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doi：
更新日期：1978-12-01 00:00:00
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journal_title：Journal of the National Medical Association
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更新日期：1991-05-01 00:00:00
