Infection caused by thymidine-requiring, trimethoprim-resistant bacteria.

Abstract:

:We first noted the appearance of thymidine-requiring, gram-negative bacilli in clinical specimens 2 years ago. Since then we have seen 10 patients colonized or infected with these organisms. These strains do not grow on Mueller-Hinton media, growth on MacConkey agar is variable, and growth in API 20E (Analytab Products) and Enterobacteriaceae-Plus Cards (AutoMicrobic system; Vitek Systems Inc.) is inadequate for reliable identifications. Thymidine-requiring organisms are routinely resistant to sulfonamides and trimethoprim. Infection or colonization is associated with previous sulfamethoxazole-trimethoprim therapy in most cases. Of 10 patients, 1 had septicemia of urinary tract origin, 5 had urinary tract colonization or infection, 2 had wound colonization, and two had colonization of respiratory secretions. Thymidine-requiring, gram-negative bacilli can be pathogens and present potential problems in diagnosis, identification, and susceptibility testing.

journal_name

J Clin Microbiol

authors

King CH,Shlaes DM,Dul MJ

doi

10.1128/JCM.18.1.79-83.1983

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

79-83

issue

1

eissn

0095-1137

issn

1098-660X

journal_volume

18

pub_type

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