Abstract:
:In situ hybridization experiments were carried out with two clones, YACG 35 and 2.8, which had been selected from two genomic libraries strongly enriched for the human Y chromosome. Besides the human Y chromosome, both sequences strongly hybridized to the human X chromosome, with few minor binding sites on autosomes. In particular, on the X chromosome DNA from clone YACG 35 hybridized to the centromeric region and the distal part of the short arm (Xp2.2). On the Y chromosome, the sequence was assigned to one site situated in the border region between Yq1.1 and Yq1.2. DNA from clone 2.8 also hybridized to the centromeric region of the X and the distal part of the short arm (Xp2.2). On the Y, however, two binding sites were observed (Yp1.1 and Yq1.2). The findings indicate that sex chromosomal sequences may be localized in homologous regions (as suggested from meiotic pairing) but also at ectopic sites.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Rappold GA,Cremer T,Cremer C,Back W,Bogenberger J,Cooke HJdoi
10.1007/BF00286513subject
Has Abstractpub_date
1984-01-01 00:00:00pages
257-61issue
3eissn
0340-6717issn
1432-1203journal_volume
65pub_type
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