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X chromosome imprinting in fragile X syndrome.

Abstract：

:Laird et al. (1987) hypothesized that there are at least four cis-acting alleles or 'chromosome states' at Xq27 that increasingly delay replication at this chromosomal area resulting in its increasing fragility in vitro. When on the inactive X chromosome, the proposed third ('mutated') allele can permanently block reactivation of its cis Xq27 area as the chromosome passes through female meiosis. Males and some females who inherit such an 'imprinted' fragile X chromosome (the fourth proposed allele) will be clinically affected due to impaired transcription of genes in the 'imprinted' Xq27 area. To test this hypothesis, late replication reverse banding patterns at Xq27 were evaluated in cultured lymphoblastoid cell lines from 25 subjects. Our data suggest that DNA replication of the presumed 'imprinted' Xq27 region in affected fragile X patients is indeed later relative to Xq27 on the active X chromosome in other subjects. These results support in part Laird's hypothesis of chromosomal imprinting in fragile X syndrome.

journal_name

Hum Genet

journal_title

Human genetics

authors

Yu WD,Wenger SL,Steele MW

doi

10.1007/BF00193580

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

590-4

issue

6

eissn

0340-6717

issn

1432-1203

journal_volume

85

pub_type

杂志文章

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