Abstract:
:In this paper observations are summarized and speculations discussed, and it is suggested that some loci on the distal short arm of the X chromosome (Xp) are not randomly inactivated in the female, because they are within the proximal part of the pairing segment between Xp and Yp. This peculiarity of gene expression may be a remnant of the evolutionary history of the sex chromosomes, the pairing segment of which may involve at least 27% of Xp and 95% of Yp. Crossing over seems to occur mostly in the terminal third of the X/Y pairing segment. However, crossing-over inhibition control may lapse, or may be somewhat variable, within the pairing segment, so that some loci on the X and Y (e.g. Xg. H-Y, STS, and perhaps others) might cross over with a variable frequency which is proportional to their distances from the telomeres of the short arms. It is postulated that the DNA of the pairing segment is composed in a way which may also permit unequal crossing over to occur between the X and the Y, thereby giving rise to exceptions to X-or Y-linked inheritance. The peculiarities of behaviour and the position of other loci on the sex chromosomes are also discussed briefly.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Polani PEdoi
10.1007/BF00303003subject
Has Abstractpub_date
1982-01-01 00:00:00pages
207-11issue
3eissn
0340-6717issn
1432-1203journal_volume
60pub_type
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