Abstract:
:We identified two informative polymorphisms in the transcribed 3' untranslated region of the tumor necrosis factor receptor 2 (TNFR2) gene using the polymerase chain reaction (PCR) with the single-strand conformation polymorphism (SSCP) technique. These polymorphisms demonstrated Mendelian inheritance and were useful for linkage analysis. TNFR2 was very closely linked to the pronatriodilatin gene (PND), and the TNFR2 SSCP polymorphisms were much more informative than the restriction fragment length polymorphisms currently available for the PND locus. In addition, we have demonstrated that genotyping could be performed with DNA obtained from paraffin-embedded tissue.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Kaufman BA,White PS,Steinbrueck T,Donis-Keller H,Brodeur GMdoi
10.1007/BF00201604subject
Has Abstractpub_date
1994-10-01 00:00:00pages
418-22issue
4eissn
0340-6717issn
1432-1203journal_volume
94pub_type
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