Abstract:
:DNA haplotype constellations of the beta-globin gene cluster have been analyzed in German families with hemoglobinopathies (Hb Freiburg, Hb Köln, Hb Presbyterian) and beta-thalassemias. The polymorphic patterns obtained were compared to those found in families from Greece, Italy, and Turkey affected by beta-thalassemia syndromes. With the combined analysis of seven restriction site polymorphisms a DNA-diagnostic prediction for additional offspring could be made with an overall frequency of 75% in the four ethnic groups.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Oehme R,Kohne E,Horst Jdoi
10.1007/BF00284577subject
Has Abstractpub_date
1985-01-01 00:00:00pages
219-22issue
3eissn
0340-6717issn
1432-1203journal_volume
71pub_type
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