Abstract:
:Three families are reported showing transmission of a previously described variant, which is not associated with any clinical abnormality. The variant involves additional material at the band 9p12, which shows homogeneous staining of intermediate density with GTL- and RBG-banding, and negative staining with CBG-banding. The region stains positively with Feulgen stain. In situ hybridization with total genomic human DNA, cloned alpha satellite, satellite III, and ribosomal DNA all show no hybridization to the 9p12 variant. Two members of one of the families show the largest 9p12 variant yet reported; two other carriers in this family have inherited a variant of decreased size. It is suggested that the 9p12 variants are homogeneously staining regions. Using the ISCN three-letter convention, this variant could be described as hsr(9)(p12).
journal_name
Hum Genetjournal_title
Human geneticsauthors
Webb GC,Krumins EJ,Eichenbaum SZ,Voullaire LE,Earle E,Choó KHdoi
10.1007/BF00288273subject
Has Abstractpub_date
1989-04-01 00:00:00pages
59-62issue
1eissn
0340-6717issn
1432-1203journal_volume
82pub_type
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