Abstract:
:Our understanding of the process of autophagy and its role in health and diseases has grown remarkably in the last two decades. Early work established autophagy as a general bulk recycling process which involves the sequestration and transport of intracellular material to the lysosome for degradation. Currently, autophagy is viewed as a nexus of metabolic and proteostatic signalling that can determine key physiological decisions from cell fate to organismal lifespan. Here, we review the latest literature on the role of autophagy and lysosomes in stress response and longevity. We highlight the connections between autophagy and metabolic processes, the network associated with its regulation, and the links between autophagic dysfunction, neurodegenerative diseases, and aging.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Wong SQ,Kumar AV,Mills J,Lapierre LRdoi
10.1007/s00439-019-02031-7subject
Has Abstractpub_date
2020-03-01 00:00:00pages
277-290issue
3eissn
0340-6717issn
1432-1203pii
10.1007/s00439-019-02031-7journal_volume
139pub_type
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