Abstract:
:From a series of 53 patients with ataxia telangiectasia, two large clones with a t tan or tct(14;14) and two with an inv(14) were observed among phytohaemagglutinin (PHA)-stimulated lymphocytes. Smaller clones with the same inv(14) were observed in two other cases. Similar breakpoints may exist, both for t(14;14) and inv(14): q11.1/q11.2 and q32, and it is postulated that the rearrangements are related to a recombination of the alpha-chain of the T-cell receptor and IgH clusters of genes.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Aurias A,Croquette MF,Nuyts JP,Griscelli C,Dutrillaux Bdoi
10.1007/BF00278811subject
Has Abstractpub_date
1986-01-01 00:00:00pages
22-4issue
1eissn
0340-6717issn
1432-1203journal_volume
72pub_type
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