Abstract:
:In our studies apolipoprotein E4 (APOE4) is associated with both early- and late-onset Alzheimer's disease. Alzheimer's patients from West Texas were screened for the APOE4 allele, which was found at frequencies of 0.43 and 0.59 in familial late- and early-onset cases. Sporadic cases had lower frequencies, but they still were 2-4 times higher than control spouses. To determine whether the APOE association may be a risk factor for coronary disease as well, we examined two APOB gene restriction sites that have previously been found to be associated with coronary artery disease, especially myocardial infarctions. The APOB alleles were found at similar frequencies in Alzheimer's patients and control spouses.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Poduslo SE,Riggs D,Schwankhaus J,Osborne A,Crawford F,Mullan Mdoi
10.1007/BF00197418subject
Has Abstractpub_date
1995-11-01 00:00:00pages
597-600issue
5eissn
0340-6717issn
1432-1203journal_volume
96pub_type
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