Abstract:
:The frequencies of base-line and Mitomycin-C (MMC) induced sister chromatid exchanges (SCE) were surveyed in four inbred strains of mice. In contrast to the C57Bl/6J, CBA/J, and A/J strains where frequencies of SCE increased linearly with increasing dose of MMC, levels of SCE were significantly lower in AKR/J mice at high MMC concentrations. At a dose of 5 mg/kg MMC, chromosomal aberrations were more frequent in bone marrow cells of AKR/J mice than in C57Bl/6J mice. These observations suggest an altered response to DNA damage in the AKR mouse strain.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Kram D,Schneider ELdoi
10.1007/BF00278870subject
Has Abstractpub_date
1978-02-23 00:00:00pages
45-51issue
1eissn
0340-6717issn
1432-1203journal_volume
41pub_type
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