Abstract:
:Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 European Americans. The SNP rs4133274 on chromosome 8q24 (72 kb upstream of MYC) revealed the most significant association with severe teenage acne (p value = 1.7 × 10(-6)). The variant allele of this SNP (G allele) was associated with an increased risk of severe teenage acne with odds ratio of 4.01 (95 % confidence interval = 2.37-6.82). Upon further replication, our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studies.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Zhang M,Qureshi AA,Hunter DJ,Han Jdoi
10.1007/s00439-013-1374-4subject
Has Abstractpub_date
2014-03-01 00:00:00pages
259-64issue
3eissn
0340-6717issn
1432-1203journal_volume
133pub_type
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