Abstract:
:Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of osteopetrosis have provided instrumental information on bone remodeling, including the coupling of bone formation to bone resorption. Based on a range of novel genetic mutations and the resulting osteoclast phenotypes, we discuss how osteopetrosis models have clarified the function of the coupling of bone formation to bone resorption, and the pivotal role of the osteoclast and their function in this phenomenon. We highlight the distinct possibility that osteoclast activities can be divided into two separate avenues: bone resorption and control of bone formation.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Segovia-Silvestre T,Neutzsky-Wulff AV,Sorensen MG,Christiansen C,Bollerslev J,Karsdal MA,Henriksen Kdoi
10.1007/s00439-008-0583-8subject
Has Abstractpub_date
2009-01-01 00:00:00pages
561-77issue
6eissn
0340-6717issn
1432-1203journal_volume
124pub_type
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