Abstract:
:Chromosome studies were carried out in four members of a sibship with a 15p+ chromosome. Two carriers had normal offspring, one was unmarried, and the index case had three abortions and no live children. By means of different banding techniques, up to four satellites and four stalks could be observed on the abnormal chromosome. The Ag-I method showed from zero to four silver precipitates on the 15p+ marker. Mean Ag-staining for 15p+ and the ten acrocentric chromosomes were obtained in the carriers. Statistically significant differences between sibs were found. These results suggest the existence of: (a) An interindividual and intercellular variation of nucleolus organizer region (NOR) activity in man. (b) An optimal threshold of NOR activity, so that disturbances at the meiotic level could occur when it is exceeded. Our conclusions lead us to advise analysis of NOR activity in individuals with extra nucleolus organizer regions.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Pérez-Castillo A,Martín-Lucas MA,Abrisqueta JAdoi
10.1007/BF00278823subject
Has Abstractpub_date
1986-01-01 00:00:00pages
80-2issue
1eissn
0340-6717issn
1432-1203journal_volume
72pub_type
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