Analysis of protein patterns from different organs and cell fractions of trisomy 19 mice.

Abstract:

:Proteins were extracted from liver, brain, and skin of 6-day-old mice with trisomy (Ts) 19 and fractionated into solubilized cell proteins and structure-bound cell proteins. The proteins were separated by two-dimensional electrophoresis, and protein patterns were compared in the combinations Ts/normal and normal/normal. Analysis of the protein patterns revealed protein spots (variants) with densities higher (h-type) or lower (l-type) in trisomies than in normal mice. Some of these variants were found in all Ts individuals investigated for a particular protein class. These variants, termed regular Ts-variants, constituted 0.8%-1.6% of the total number of spots. The proteins of the regular Ts variants were in most cases organ-nonspecific. However, in almost all cases a given quantitative variation was expressed in only one of the three organs investigated. To explain our results, we have presented models for the control of protein levels on the basis of gene regulation. New aspects in the conception of studies on trisomies in man could be gained.

journal_name

Hum Genet

journal_title

Human genetics

authors

Zeindl-Eberhart E,Grohé G,Klose J

doi

10.1007/BF00291429

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

371-8

issue

4

eissn

0340-6717

issn

1432-1203

journal_volume

77

pub_type

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