Abstract:
:Colostrum was collected and pooled from each of five cows in three experimental groups: group I cows received intramuscular and intramammary inoculations of adjuvanted modified live Ohio Agricultural Research and Development Center rotavirus vaccine; group II cows were injected intramuscularly with a commercial modified-live rota-coronavirus vaccine; and group III cows were uninoculated controls. Pooled colostrum from group I cows had higher (P less than 0.05) enzyme-linked immunosorbent assay (ELISA) immunoglobulin G (IgG1) and virus neutralization (VN) rotavirus antibody titers (ELISA IgG1 = 2,413,682; VN = 360,205) than did colostrum from group II (ELISA IgG1 = 8,192; VN = 4,395) or group III cows (ELISA IgG1 = 5,916; VN = 2,865). The antibody titers of these last two colostrum pools did not differ (P greater than 0.05). Samples of these colostrum pools were fed as daily supplements (percent [vol/vol] in cow's milk infant formula) to 28 newborn, unsuckled, antibody-seronegative, male Holstein calves. Eight calves received no supplemental colostrum. The calves were orally challenged with virulent bovine rotavirus and monitored daily for diarrhea and fecal rotavirus shedding. Diarrhea and rotavirus shedding occurred in the eight calves fed no supplemental colostrum and persisted longest in this group. The pooled colostrum from group I cows protected eight of eight calves from both rotavirus diarrhea and shedding when fed as a 1% supplement. The pooled colostrum from neither group II nor group III cows protected 12 other calves against rotavirus diarrhea or shedding when fed at the same concentration (1%). Six rotavirus-challenged calves fed 0.1% supplemental colostrum from group I cows and two calves fed 10 and 50% supplemental colostrum from control cows displayed partial passive immunity, exemplified by delayed onset and shortened duration of rotavirus-associated diarrhea and virus shedding.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Saif LJ,Redman DR,Smith KL,Theil KWdoi
10.1128/IAI.41.3.1118-1131.1983subject
Has Abstractpub_date
1983-09-01 00:00:00pages
1118-31issue
3eissn
0019-9567issn
1098-5522journal_volume
41pub_type
杂志文章abstract::The virulence plasmids of Salmonella typhimurium and other invasive Salmonella serovars have long been associated with the ability of these bacteria to cause systemic infection beyond the intestines in orally inoculated animals. Genetic analysis of virulence genes on the high-molecular-weight plasmids has revealed tha...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.2.504-511.1993
更新日期:1993-02-01 00:00:00
abstract::An enhanced memory response, as shown by increased titers of specific immunoglobulin A (IgA), was seen in intestinal secretions from isolated Thiry-Vella loops in rabbits primed orally with live, locally invasive Shigella sp. X16 and challenged 60 days later with a single oral dose of the same antigen. Heat-killed shi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.123-128.1985
更新日期:1985-01-01 00:00:00
abstract::In attempts to reactivate latent herpes simplex virus, we instilled Diplococcus pneumoniae intratracheally into mice harboring latent infections in sacrosciatic spinal ganglia. All mice developed a severe pneumonia within 24 h and were given penicillin therapy. Representative mice that survived the penumonia were sacr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.4.635-639.1975
更新日期:1975-04-01 00:00:00
abstract::Rocky Mountain spotted fever, a systemic tick-borne illness caused by the obligate intracellular bacterium Rickettsia rickettsii, is associated with widespread infection of the vascular endothelium. R. rickettsii infection induces a biphasic pattern of the nuclear factor-kappaB (NF-kappaB) activation in cultured human...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.1.155-165.2005
更新日期:2005-01-01 00:00:00
abstract::Secretion of immunoglobulin A1 (IgA1) proteases is a characteristic of Haemophilus influenzae and several other bacterial pathogens causing infectious diseases, including meningitis. Indirect evidence suggests that the proteases are important virulence factors. In this study, we cloned the iga gene encoding immunoglob...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.10.3097-3105.1989
更新日期:1989-10-01 00:00:00
abstract::Free-living amoebae of the genus Acanthamoeba can cause severe and chronic infections in humans, mainly localized in immune privileged sites, such as the brain and the eye. Monocytes/macrophages are thought to be involved in Acanthamoeba infections, but little is known about how these facultative parasites influence t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00345-16
更新日期:2016-09-19 00:00:00
abstract::The hemolytic activity of the thermostable direct hemolysin produced by Vibrio parahaemolyticus was inhibited by a ganglioside mixture. The ganglioside component which inhibited the hemolysin was not FM1 ganglioside. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.4.931-933.1975
更新日期:1975-10-01 00:00:00
abstract::Yersinia pseudotuberculosis inv mutant strains cured of the virulence plasmid exhibit thermoinducible adhesion to cultured mammalian cells. To identify the genes responsible for this phenotype, Y. pseudotuberculosis homologs of the Y. enterocolitica ail and the Y. pestis psa loci were identified. Mutations in the Y. p...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2483-2489.1996
更新日期:1996-07-01 00:00:00
abstract::Tuberculosis remains a leading killer worldwide, and new approaches for its treatment and prevention are urgently needed. This effort will benefit greatly from a better understanding of gene regulation in Mycobacterium tuberculosis, particularly with respect to this pathogen's response to its host environment. We exam...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.3.1518-1529.2002
更新日期:2002-03-01 00:00:00
abstract::Vesicular stomatitis virus (Indiana strain) will only grow in T lymphocytes which have been stimulated to undergo cell division. Evidence is presented that a considerable enrichment of the vesicular stomatitis virus-replicating T cells may be accomplished in the mouse spleen by passing the spleen cells over glass wool...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.1.169-172.1981
更新日期:1981-04-01 00:00:00
abstract::Salmonellae with differences only in the O-antigenic polysaccharide of their lipopolysaccharide were previously shown to differentially activate complement via the alternative pathway, causing them to be ingested at different rates by the mouse macrophage-like cell line J774. We now show that this mechanism could expl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.2.563-569.1983
更新日期:1983-08-01 00:00:00
abstract::As part of a study of virulence gene regulation in Streptococcus pneumoniae, we have identified a gene encoding a homologue of the staphylococcal catabolite control protein CcpA in the pneumococcal genome sequence. The pneumococcal protein, designated RegM, has significant similarity to members of the LacI/GalR family...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.10.5454-5461.2002
更新日期:2002-10-01 00:00:00
abstract::Anaplasma phagocytophilum is an obligate intracellular bacterium that infects myeloid cells in the mammalian host. Msp2 (p44) is the major immunodominant outer-membrane protein of these bacteria. We hypothesized that Msp2 acts as an adhesin for A. phagocytophilum entry into granulocytes. This potential role was invest...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.7.4018-4025.2003
更新日期:2003-07-01 00:00:00
abstract::CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4(-/-)) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4(-/-) mice wit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00310-08
更新日期:2008-11-01 00:00:00
abstract::Intestinal segmented filamentous bacteria (SFB) protect from ameba infection, and protection is transferable with bone marrow dendritic cells (BMDCs). SFB cause an increase in serum amyloid A (SAA), suggesting that SAA might mediate SFB's effects on BMDCs. Here we further explored the role of bone marrow in SFB-mediat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00316-16
更新日期:2016-09-19 00:00:00
abstract::Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an important host-protective antigen. However, this molecule is toxic and requires inactivation prior to its use as a vaccine. Three genetically toxoided, nonhemolytic PLO molecules, HIS-PLO.F(497), HIS-PLO.Delta P(499), and HI...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.5.2966-2969.2003
更新日期:2003-05-01 00:00:00
abstract::Malaria infection treatment vaccine (ITV) is a promising strategy to induce homologous and heterologous protective immunity against the blood stage of the parasite. However, the underlying mechanism of protection remains largely unknown. Here, we found that a malaria-specific antibody (Ab) could mediate the protective...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02621-14
更新日期:2015-05-01 00:00:00
abstract::Pneumocystis carinii pneumonia (PcP) is a clinically important infection of immunocompromised patients. Although the interaction of Pneumocystis with the alveolar epithelium has been well documented, very little information regarding the epithelial response to Pneumocystis is currently available. In order to study Pne...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.2766-2777.2005
更新日期:2005-05-01 00:00:00
abstract::Fimbrial adhesins that mediate attachment to host cells are produced by most virulent Escherichia coli isolates. These virulence factors play an important role in the initial stages of bacterial colonization and also in determination of the host and tissue specificity. Isolates belonging to serotype O78 are known to c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.5901-5907.2000
更新日期:2000-10-01 00:00:00
abstract::The importance of bacterial phospholipases during serum-mediated killing of Escherichia coli was examined by using wild-type DR+ DS+ and an isogenic phospholipase-deficient mutant DR- DS-. No difference in serum sensitivity was observed when the parental DR+ DS+ and mutant DR- DS- strains were exposed to various conce...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.1.183-188.1977
更新日期:1977-10-01 00:00:00
abstract::Salmonella serovars are associated with human diseases that range from mild gastroenteritis to host-disseminated enteric fever. Human infections by Salmonella enterica serovar Typhi can lead to typhoid fever, but this serovar does not typically cause disease in mice or other animals. In contrast, S. enterica serovar T...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.3.1005-1013.2000
更新日期:2000-03-01 00:00:00
abstract::Gastroesophageal reflux (GER) frequently occurs in patients with respiratory disease and is particularly prevalent in patients with cystic fibrosis. GER is a condition in which the duodenogastric contents of the stomach leak into the esophagus, in many cases resulting in aspiration into the respiratory tract. As such,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00674-13
更新日期:2014-09-01 00:00:00
abstract::Controversy persists over the role that the capsular polysaccharide plays in the pathogenesis of Staphylococcus aureus infections. To address this issue, we compared the mouse virulence of S. aureus Reynolds and capsule-defective mutant strains cultivated under conditions of high or low capsule expression. Strain Reyn...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.11.5183-5189.1998
更新日期:1998-11-01 00:00:00
abstract::Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.10.4407-4409.1992
更新日期:1992-10-01 00:00:00
abstract::Clinical trials of novel tuberculosis (TB) vaccines are expensive, while global resources for TB vaccine development are limited. Therefore, there is a need for robust and predictive preclinical data to support advancement of candidate vaccines into clinical trials. Here, we provide a rationale for using the nonhuman ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00776-17
更新日期:2018-01-22 00:00:00
abstract::The human gastric pathogen Helicobacter pylori modifies host cholesterol via glycosylation and incorporates the glycosylated cholesterol into its membrane; however, the benefits of cholesterol to H. pylori are largely unknown. We speculated that cholesterol in the H. pylori membrane might alter the susceptibility of t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00974-09
更新日期:2011-01-01 00:00:00
abstract::The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) is responsible for significant infant mortality and morbidity, particularly in developing countries. EPEC pathogenesis relies on a type III secretion system-mediated transfer of virulence effectors into host cells. EPEC modulates host cell survival an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01690-06
更新日期:2007-05-01 00:00:00
abstract::The facultative intracellular bacterial pathogen Listeria monocytogenes induces severe fetal infection during pregnancy. Little is known about the molecular mechanisms allowing the maternofetal transmission of bacteria. In this work, we studied fetoplacental invasion by infecting mice with various mutants lacking viru...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01570-06
更新日期:2007-02-01 00:00:00
abstract::A total of 133 Listeria monocytogenes isolates were characterized by ribotyping and allelic analysis of the virulence genes hly, actA, and inlA to uncover linkages between independent phylogenetic and specific virulence markers. PCR-restriction fragment length polymorphisms revealed 8 hly, 11 inl4, and 2 actA alleles....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.7.2707-2716.1997
更新日期:1997-07-01 00:00:00
abstract::The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.7.3637-3640.1999
更新日期:1999-07-01 00:00:00