Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia.

abstract：:von Willebrand factor (VWF), a protein present in our circulatory system, is necessary to stop bleeding under high shear-stress conditions as found in small blood vessels. The results presented here help unravel how an increase in hydrodynamic shear stress activates VWF's adhesion potential, leading to the counterintu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider SW,Nuschele S,Wixforth A,Gorzelanny C,Alexander-Katz A,Netz RR,Schneider MF

更新日期：2007-05-08 00:00:00

abstract：:Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels, cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate receptors in cerebellar slices. Nitric oxide synthase (EC 1.14.23.-) immunoreactivity is colocalized with nicotinamide adenine di-nucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dawson VL,Dawson TM,London ED,Bredt DS,Snyder SH

更新日期：1991-07-15 00:00:00

abstract：:We have isolated several lines of rat embryo cells transformed by simian virus 40. All these lines are fully transformed with regard to saturation density and serum sensitivity, but they differ greatly in their anchorage dependence, as assayed by efficiency of plating in methyl cellulose suspension. This set of lines ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pollack R,Risser R,Conlon S,Rifkin D

更新日期：1974-12-01 00:00:00

abstract：:In the course of scrapie, a transmissible spongiform encephalopathy caused by an unconventional agent, a normal cellular protein is converted to an abnormal form that copurifies with infectivity and aggregates to form deposits of amyloid. We have used immunocytochemistry and methods that enhance detection of amyloidog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diedrich JF,Bendheim PE,Kim YS,Carp RI,Haase AT

更新日期：1991-01-15 00:00:00

abstract：:We have established empirical limits for the circular dichroism spectra appropriate for aqueous solutions of the B, C, and A forms of calf-thymus DNA and have analyzed DNA conformations in biological structures. The circular dichroism spectrum above 250 nm of purified calf-thymus chromatin can be satisfactorily accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanlon S,Johnson RS,Wolf B,Chan A

更新日期：1972-11-01 00:00:00

abstract：:The complexity and specificity of metazoan transcription are determined by combinatorial control of the composition and activity of regulatory complexes. To investigate the basis of this specificity, we focused on the glucocorticoid receptor (GR), a single regulatory factor that integrates multiple signals to give ris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen SH,Masuno K,Cooper SB,Yamamoto KR

更新日期：2013-01-29 00:00:00

abstract：:Arsenic poisoning affects millions of people worldwide. Human arsenic intake from rice consumption can be substantial because rice is particularly efficient in assimilating arsenic from paddy soils, although the mechanism has not been elucidated. Here we report that two different types of transporters mediate transpor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma JF,Yamaji N,Mitani N,Xu XY,Su YH,McGrath SP,Zhao FJ

更新日期：2008-07-22 00:00:00

abstract：:Chloroplast DNA (cpDNA) is under great photooxidative stress, yet its evolution is very conservative compared with nuclear or mitochondrial genomes. It can be expected that DNA repair mechanisms play important roles in cpDNA survival and evolution, but they are poorly understood. To gain insight into how the most seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon T,Huq E,Herrin DL

更新日期：2010-08-03 00:00:00

abstract：:Future nuclear arms reduction efforts will require technologies to verify that warheads slated for dismantlement are authentic without revealing any sensitive weapons design information to international inspectors. Despite several decades of research, no technology has met these requirements simultaneously. Recent wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vavrek JR,Henderson BS,Danagoulian A

更新日期：2018-04-24 00:00:00

abstract：:Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hale JS,Boursalian TE,Turk GL,Fink PJ

更新日期：2006-05-30 00:00:00

abstract：:There are two competing hypotheses for the origin of megaliths in Europe. The conventional view from the late 19th and early 20th centuries was of a single-source diffusion of megaliths in Europe from the Near East through the Mediterranean and along the Atlantic coast. Following early radiocarbon dating in the 1970s,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz Paulsson B

更新日期：2019-02-26 00:00:00

abstract：:Histone acetylation is a major epigenetic control mechanism that is tightly linked to the promotion of gene expression. Histone acetylation levels are balanced through the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Arabidopsis HDAC genes (AtHDACs) compose a large gene fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YJ,Wang R,Gao L,Li D,Xu C,Mang H,Jeon J,Chen X,Zhong X,Kwak JM,Mo B,Xiao L,Chen X

更新日期：2016-12-20 00:00:00

abstract：:Tetrodotoxin-sensitive sodium channels are detectable in normal human fibroblasts and in "glia-like" cells at appreciable levels when compared to what is observed in established neuronal cell lines in culture. Two- to 3-fold stimulations of sodium influx are observed in the presence of 0.2 mM veratridine and scorpion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munson R Jr,Westermark B,Glaser L

更新日期：1979-12-01 00:00:00

abstract：:The stress inoculation hypothesis presupposes that brief intermittent stress exposure early in life induces the development of subsequent stress resistance in human and nonhuman primates. Rodent studies, however, suggest a role for maternal care rather than stress exposure per se (i.e., the maternal mediation hypothes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker KJ,Buckmaster CL,Sundlass K,Schatzberg AF,Lyons DM

更新日期：2006-02-21 00:00:00

abstract：:The pathogenesis of tuberculous meningitis, a devastating complication of tuberculosis in man, is poorly understood. We previously reported that rabbits with experimental tuberculous meningitis were protected from death by a combination of antibiotics and thalidomide therapy. Survival was associated with inhibition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsenova L,Bergtold A,Freedman VH,Young RA,Kaplan G

更新日期：1999-05-11 00:00:00

abstract：:A hallmark of rheumatoid arthritis is the formation of an aggressive, tumor-like structure called pannus that erodes the joint. A major cellular component of the pannus is the fibroblast-like synoviocyte (FLS), whose morphology strikingly resembles that of a transformed cell, but underlying mechanisms of this "transfo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Makarov SS

更新日期：2006-11-14 00:00:00

abstract：:To examine the hypothesis that bone marrow consists of discrete stem cell regulatory volumes or domains, we studied spleen colony-forming unit (CFU-S) population growth kinetics in unirradiated WBB6F1-W/Wv mice receiving various doses of +/+ bone marrow cells. Assay of femoral marrow CFU-S content in the eight recipie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maloney MA,Lamela RA,Banda MJ,Patt HM

更新日期：1982-02-01 00:00:00

abstract：:The heavy chains of both botulinum neurotoxin type B and tetanus toxin form channels in planar bilayer membranes. These channels have pH-dependent and voltage-dependent properties that are remarkably similar to those previously described for diphtheria toxin. Selectivity experiments with anions and cations show that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoch DH,Romero-Mira M,Ehrlich BE,Finkelstein A,DasGupta BR,Simpson LL

更新日期：1985-03-01 00:00:00

abstract：:A chromosomal locus required for copper resistance and competitive fitness was cloned from a strain of Pseudomonas fluorescens isolated from copper-contaminated agricultural soil. Sequence analysis of this locus revealed six open reading frames with homology to genes involved in cytochrome c biogenesis in other bacter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang CH,Azad HR,Cooksey DA

更新日期：1996-07-09 00:00:00

abstract：:Equity is of fundamental concern in the quest for international cooperation to stabilize greenhouse gas concentrations by the reduction of emissions. By modeling the carbon cycle, we estimate the global CO(2) emissions that would be required to stabilize the atmospheric concentration of CO(2) at levels ranging from 45...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolin B,Kheshgi HS

更新日期：2001-04-24 00:00:00

abstract：:A type of chromosome-free cell called SimCells (simple cells) has been generated from Escherichia coli, Pseudomonas putida, and Ralstonia eutropha. The removal of the native chromosomes of these bacteria was achieved by double-stranded breaks made by heterologous I-CeuI endonuclease and the degradation activity of end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan C,Davison PA,Habgood R,Zeng H,Decker CM,Gesell Salazar M,Lueangwattanapong K,Townley HE,Yang A,Thompson IP,Ye H,Cui Z,Schmidt F,Hunter CN,Huang WE

更新日期：2020-03-24 00:00:00

abstract：:Gene transfer into early embryos is a powerful methodology for unraveling the molecular bases of developmental processes. One can attempt to minimize widespread effects of an exogenous gene by using tissue- or region-specific promoters in the few instances where they are available. We have developed a method that bypa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fekete DM,Cepko CL

更新日期：1993-03-15 00:00:00

abstract：:Life history events, such as traumatic stress, illness, or starvation, can influence us through molecular changes that are recorded in a pattern of characteristic chromatin modifications. These modifications are often associated with adaptive adjustments in gene expression that can persist throughout the lifetime of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demoinet E,Li S,Roy R

更新日期：2017-03-28 00:00:00

abstract：:The extensive refolding of the membrane-anchoring chain of hemagglutinin (HA) of influenza virus (termed HA2) in cellular endosomes, which initiates viral entry by membrane fusion, suggests that viral HA is meta-stable. HA2 polypeptide residues 38-175 expressed in Escherichia coli are reported here to fold in vivo int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Wharton SA,Weissenhorn W,Calder LJ,Hughson FM,Skehel JJ,Wiley DC

更新日期：1995-12-19 00:00:00

abstract：:Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague-Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of mutant SOD1 expression,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howland DS,Liu J,She Y,Goad B,Maragakis NJ,Kim B,Erickson J,Kulik J,DeVito L,Psaltis G,DeGennaro LJ,Cleveland DW,Rothstein JD

更新日期：2002-02-05 00:00:00

abstract：:The surface distributions of three different membrane integral proteins, beta2-microglobulin (part of the histocompatibility antigen complex), aminopeptidase (alpha-aminoacyl-peptide hydrolase; EC 3.4.11.2), and the Na+,K+-ATPase (ATP phosphohydrolase; EC 3.6.1.3) on human fibroblasts grown in monolayer culture have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ash JF,Louvard D,Singer SJ

更新日期：1977-12-01 00:00:00

abstract：:Growth factor-induced signals govern the expression of three D-type cyclins, which, in turn, function as regulatory subunits of cyclin-dependent kinases (cdks) to control cell cycle transitions during the late G1 interval. 32D myeloid cells, which self-renew as uncommitted precursors in interleukin 3 (IL-3), express c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato JY,Sherr CJ

更新日期：1993-12-15 00:00:00

abstract：:The super-enhancers (SEs) of lineage-specific genes in B cells are off-target sites of somatic hypermutation. However, the inability to detect sufficient numbers of mutations in normal human B cells has precluded the generation of a high-resolution mutational landscape of SEs. Here we captured and sequenced 12 B cell ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen JC,Kamath-Loeb AS,Kohrn BF,Loeb KR,Preston BD,Loeb LA

更新日期：2019-12-03 00:00:00

abstract：:There is evidence both for and against Na(+)- and Cl(-)-dependent neurotransmitter transporters forming oligomers. We found that cross-linking the human dopamine transporter (DAT), which is heterologously expressed in human embryonic kidney 293 cells, either with copper phenanthroline (CuP) or the bifunctional reagent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hastrup H,Karlin A,Javitch JA

更新日期：2001-08-28 00:00:00

abstract：:For taxonomic levels higher than species, the abundance distributions of the number of subtaxa per taxon tend to approximate power laws but often show strong deviations from such laws. Previously, these deviations were attributed to finite-time effects in a continuous-time branching process at the generic level. Inste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu J,Adami C

更新日期：1999-12-21 00:00:00