Substantia nigra and ventral tegmental area projections to cortex: topography and collateralization.

abstract：:Early gestation is a neurodevelopmental period that is especially vulnerable to environmental insult and one in which neurogenesis features prominently. Prenatal perturbation during early gestation has been linked to neuropsychiatric illnesses such as autism and schizophrenia, and severe environmental insult during th...

journal_title：Neuroscience

authors： Selemon LD,Begovic A

更新日期：2020-08-21 00:00:00

abstract：:The cytotoxic effects of DL-, D- and L-alpha-aminoadipic acid, a six-carbon homologue of glutamate, were investigated in cell cultures of dissociated postnatal mouse cerebellum. Treatment with alpha-aminoadipic acid resulted in rapid nuclear and cytoplasmic swelling and, after longer periods of exposure, karyopyknosis...

journal_title：Neuroscience

authors： Huck S,Grass F,Hatten ME

更新日期：1984-07-01 00:00:00

abstract：:Slices of striatal tissue from newborn to eight-day-old rats were cultured for six to 47 days. Cholinergic neurons and fibres were then visualized by histochemical staining for acetylcholinesterase or immunocytochemical staining for choline acetyltransferase. GABA-containing neurons and fibres were visualized by immun...

journal_title：Neuroscience

authors： Ostergaard K

更新日期：1993-04-01 00:00:00

abstract：:We investigated the effects of intracerebroventricular injection of angiotensin II on neuronal immediate early gene-encoded protein synthesis in the brain of conscious rats. The expression of seven immediate early gene-encoded transcription factors (c-Fos, FosB, c-Jun, JunB, JunD, Krox-20 (Egr-2) and Krox-24 (NGFI-A, ...

journal_title：Neuroscience

authors： Lebrun CJ,Blume A,Herdegen T,Seifert K,Bravo R,Unger T

更新日期：1995-03-01 00:00:00

abstract：:Prolonged stress triggers neuroinflammation, which plays a significant role in the development of depression; however, stressed people do not always suffer from depression because of individual differences in stress vulnerability. Negative cognitive bias (NCB) toward pessimistic judgment often underlies depressive epi...

journal_title：Neuroscience

authors： Ito N,Sasaki K,Takemoto H,Kobayashi Y,Isoda H,Odaguchi H

更新日期：2020-09-01 00:00:00

abstract：:Little is known about the G protein-coupled receptor desensitization process during pregnancy. Wistar pregnant rats were treated with (-)N(6)-phenylisopropyladenosine (R-PIA), an adenosine A(1) receptor (A(1)R) agonist, in their drinking water during pregnancy, and the effect on A(1)R/adenylyl cyclase system was studi...

journal_title：Neuroscience

authors： León DA,Castillo CA,Albasanz JL,Martín M

更新日期：2009-10-06 00:00:00

abstract：:The role of the oxytocin-containing projections to the autonomic nuclei of the spinal cord for lower urinary tract function has not been clarified. The hypothesis was tested that oxytocin acts as a mediator of bladder contraction at the spinal cord level. In conscious female rats undergoing continuous cystometry, intr...

journal_title：Neuroscience

authors： Pandita RK,Nylén A,Andersson KE

更新日期：1998-08-01 00:00:00

abstract：:We examined the immunohistochemical regional distribution of calcineurin (Ca2+/calmodulin-dependent protein phosphatase) in the adult rat hippocampus, following various regional destruction. In the normal adult rat hippocampus, the calcineurin immunoreactivity showed a characteristic pattern. This protein phosphatase ...

journal_title：Neuroscience

authors： Morioka M,Nagahiro S,Fukunaga K,Miyamoto E,Ushio Y

更新日期：1997-06-01 00:00:00

abstract：:The enkephalin-like immunoreactivity in the retina of chicks has been studied using immunohistochemical and radioimmunoassay techniques. The histochemical experiments showed that the immunoreactivity was confined to a subpopulation of amacrine cells in the inner nuclear layer which projected processes into sublaminae ...

journal_title：Neuroscience

authors： Millar TJ,Salipan N,Oliver JO,Morgan IG,Chubb IW

更新日期：1984-09-01 00:00:00

abstract：:The neuronal uptake and laminar distribution of cortically injected tritium-labeled gamma-aminobutyrate (GABA), aspartic acid, glutamate and glycine was examined in the prestriate cortex of squirrel monkeys. The intent of this investigation was not to examine the role of these amino acids as neurotransmitters, but to ...

journal_title：Neuroscience

authors： Carroll EW,Wong-Riley M

更新日期：1987-08-01 00:00:00

abstract：:We previously reported that the novel antidepressant-like effect of tipepidine may be produced at least partly through the activation of mesolimbic dopamine (DA) neurons via inhibiting G protein-coupled inwardly rectifying potassium (GIRK) channels. In this study, we investigated the action of tipepidine on DA D2 rece...

journal_title：Neuroscience

authors： Hamasaki R,Shirasaki T,Soeda F,Takahama K

更新日期：2013-11-12 00:00:00

abstract：:We investigated computer models of a single thalamocortical neuron to assess the interaction of intrinsic voltage-sensitive channels and cortical synaptic input in producing the range of oscillation frequencies observed in these cells in vivo. A morphologically detailed model with Hodgkin-Huxley-like ion channels demo...

journal_title：Neuroscience

authors： Lytton WW,Destexhe A,Sejnowski TJ

更新日期：1996-02-01 00:00:00

abstract：:Alterations in the phosphorylation state of the microtubule-associated protein tau have been associated with the pathogenesis of neurofibrillary degeneration as well as with a neuroprotective action against apoptotic cell death. Mitogen-activated protein kinases (MAPK) phosphorylate tau protein in vitro but the pathop...

journal_title：Neuroscience

authors： Holzer M,Gärtner U,Klinz FJ,Narz F,Heumann R,Arendt T

更新日期：2001-01-01 00:00:00

abstract：:Vascular endothelial cells were activated during acute ischemic brain injury, which could induce neural progenitor cell proliferation and migration. However, the mechanism was still unknown. In the current study, we explored whether vascular endothelial cells promoted neural progenitor cell proliferation and whether m...

journal_title：Neuroscience

authors： Zhou S,Gao B,Sun C,Bai Y,Cheng D,Zhang Y,Li X,Zhao J,Xu D

更新日期：2020-08-10 00:00:00

abstract：:The cortical representation of the body surface is not fixed, but rather, is continuously modified by ongoing changes in sensory experience. Although the cellular and molecular mechanisms that subserve these changes are uncertain, increasing evidence suggests that synaptically-released zinc may play a role. Zinc is re...

journal_title：Neuroscience

authors： Brown CE,Dyck RH

更新日期：2005-01-01 00:00:00

abstract：:Bitter taste serves as an important signal for potentially poisonous compounds in foods to avoid their ingestion. Thousands of compounds are estimated to taste bitter and presumed to activate taste receptor cells expressing bitter taste receptors (Tas2rs) and coupled transduction components including gustducin, phosph...

journal_title：Neuroscience

authors： Yoshida R,Takai S,Sanematsu K,Margolskee RF,Shigemura N,Ninomiya Y

更新日期：2018-01-15 00:00:00

abstract：:5-Hydroxytrytamine (serotonin) type 3A receptors (5-HT3ARs), as the only ligand-gated ion channels in the serotonin receptor family, are known to regulate neuronal excitation and release of GABA in hippocampal interneurons. However, their physiological role in glutamatergic synaptic plasticity remains unclear. Here, w...

journal_title：Neuroscience

authors： Yu Y,Cao DQ,Xu HY,Sun M,Huang ZL,Yung WH,Lu N,Huang Y

更新日期：2014-10-10 00:00:00

abstract：:The nodose ganglion contains placode-derived visceral sensory neurons of the vagus nerve. Previous study showed that axotomy-induced deafferentation reduced the number of tyrosine hydroxylase-immunoreactive and increased the number of vasoactive intestinal peptide-immunoreactive neurons in the ganglion. The present st...

journal_title：Neuroscience

authors： Zhuo H,Sinclair C,Helke CJ

更新日期：1994-11-01 00:00:00

abstract：:Interactions between dopamine and glutamate receptors are essential for the prefrontal cortical (PFC) and hippocampal cognitive functions. In order to understand the molecular basis of dopamine/glutamate interactions in rat PFC and hippocampus, we investigated (a) the effect of in vitro dopamine D1 receptor stimulatio...

journal_title：Neuroscience

authors： Sarantis K,Matsokis N,Angelatou F

更新日期：2009-11-10 00:00:00

abstract：:The responses in T3-4, T10-11 and L2-3 white rami to stimulation of different zones of the bulbar ventrolateral surface were maximal when the region of about 4 mm laterally to the midline was stimulated. A weak surface stimulation of all these zones elicited only a long latency response consisting of three waves. A sh...

journal_title：Neuroscience

authors： Lebedev VP,Krasyukov AV,Nikitin SA

更新日期：1986-01-01 00:00:00

abstract：:Microglia, the resident tissue macrophages of the central nervous system, have a highly differentiated morphology and do not express many of the antigens typically associated with other tissue macrophages. Activation of microglia is associated with a change in morphology and an increase in their repertoire of antigen ...

journal_title：Neuroscience

authors： Reid DM,Perry VH,Andersson PB,Gordon S

更新日期：1993-10-01 00:00:00

abstract：:Imaging genetics has emerged as a powerful and sensitive approach to the study of functional genetic variations and brain responses in psychiatric and neurologic disorders. Ethics issues in contemporary neuroscience as they apply separately to genetics and neuroimaging have been a growing focus for research but, to da...

journal_title：Neuroscience

authors： Tairyan K,Illes J

更新日期：2009-11-24 00:00:00

abstract：:Considerable evidence suggests that dynorphin participates in the regulation of energy balance. In this study, we have used immunohistochemistry to investigate in detail the cellular localization of pro-dynorphin (DYN) immunoreactive cell bodies in the mediobasal hypothalamus with special reference to neurons producin...

journal_title：Neuroscience

authors： Maolood N,Meister B

更新日期：2008-06-26 00:00:00

abstract：:Most functional imaging studies of memory retrieval investigate memory for standardized laboratory stimuli. However, naturally acquired autobiographical memories differ from memories of standardized stimuli in important ways. Neuroimaging studies of natural memories may reveal distinctive patterns of brain activation ...

journal_title：Neuroscience

authors： Maddock RJ,Garrett AS,Buonocore MH

更新日期：2001-01-01 00:00:00

abstract：:Many behaviorally relevant sounds, including language, are composed of brief, rapid, repetitive acoustic features. Recent studies suggest that abnormalities in producing and understanding spoken language are correlated with abnormal neural responsiveness to such auditory stimuli at higher auditory levels [Tallal et al...

journal_title：Neuroscience

authors： Bartlett EL,Smith PH

更新日期：2002-01-01 00:00:00

abstract：:Several lines of clinical evidence support the idea that fragile X syndrome (FXS) may involve a dysregulation of hypothalamic-pituitary-adrenal axis function [Wisbeck et al. (2000) J Dev Behav Pediatr 21:278-282; Hessl et al. (2002) Psychoneuroendocrinology 27:855-872]. We had tested this idea in a mouse model of FXS ...

journal_title：Neuroscience

authors： Qin M,Xia Z,Huang T,Smith CB

更新日期：2011-10-27 00:00:00

abstract：:Brain injury-derived neurotrophic peptide is a 13-amino acid peptide derived from a 15,000 mol. wt neurotrophic factor released from sites of mechanical injury in neonatal rat brain. This peptide promotes survival of septal cholinergic neurons and mesencephalic dopaminergic neurons, and protects hippocampal neurons fr...

journal_title：Neuroscience

authors： Hama T,Maruyama M

更新日期：2000-01-01 00:00:00

abstract：:The presence of subgroups in vomeronasal sensory neurons has been known in various animals. To elucidate possible functional subdivisions in the guinea-pig accessory olfactory bulb, the combined studies with GTP-binding protein immunohistochemistry, electrophysiological and optical recordings were carried out. Gi2 alp...

journal_title：Neuroscience

authors： Sugai T,Sugitani M,Onoda N

更新日期：1997-08-01 00:00:00

abstract：:Intrathecally-administered endomorphin-1 and endomorphin-2 produce antinociceptive effects which are different from each other. In order to elucidate a cellular basis for this result, we examined the effects of endomorphin-1 and endomorphin-2 on holding currents and spontaneous glutamatergic excitatory transmission in...

journal_title：Neuroscience

authors： Fujita T,Kumamoto E

更新日期：2006-01-01 00:00:00

abstract：:The lack of environmental olfactory stimulation produced by sensory deprivation causes significant changes in the deprived olfactory bulb. Olfactory transmission in the main olfactory bulb (MOB) is strongly modulated by centrifugal systems. The present report examines the effects of unilateral deprivation on the norad...

journal_title：Neuroscience

authors： Gómez C,Briñón JG,Colado MI,Orio L,Vidal M,Barbado MV,Alonso JR

更新日期：2006-09-15 00:00:00