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Synthesis and biological activity of 17-esters of 6-dehydro-16-methylene-17 -hydroxyprogesterones.

Abstract：

:Synthesis and biological activity of 17-esters of 6-dehydro-16-methylene-17 alpha-hydroxyprogesterone are presented. A systematic study of the influence of the alteration of halogen at 6 and the acyl group at 17 on the progestational and antiandrogenic activities of the resulting structures is described. A convenient general method for synthesis of all of the members of the generic family from the precursors in common is described. It is believed that 6-chloro-16-methylene-17 alpha-hydroxy-4,6-pregnadiene 17-acetate, because of its structural similarity to chlormadinone acetate and its high progestational potency, will perform as a contraceptive at perhaps a lower dose than that of chlormadinone acetate.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Shapiro EL,Weber L,Harris H,Miskowicz C,Neri R,Herzog HL

doi

10.1021/jm00277a006

subject

Has Abstract

pub_date

1972-07-01 00:00:00

pages

716-20

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

15

pub_type

杂志文章

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