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Contributions of academic laboratories to the discovery and development of chemical biology tools.

Abstract：

:The academic setting provides an environment that may foster success in the discovery of certain types of small molecule tools while proving less suitable in others. For example, small molecule probes for poorly understood systems, those that exploit a specific resident expertise, and those whose commercial return is not apparent are ideally suited to be pursued in a university setting. In this review, we highlight five projects that emanated from academic research groups and generated valuable tool compounds that have been used to interrogate biological phenomena: reactive oxygen species (ROS) sensors, GPR30 agonists and antagonists, selective CB2 agonists, Hsp70 modulators, and β-amyloid PET imaging agents. By taking advantage of the unique expertise resident in university settings and the ability to pursue novel projects that may have great scientific value but with limited or no immediate commercial value, probes from academic research groups continue to provide useful tools and generate a long-term resource for biomedical researchers.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Huryn DM,Resnick LO,Wipf P

doi

10.1021/jm400132d

subject

Has Abstract

pub_date

2013-09-26 00:00:00

pages

7161-76

issue

18

eissn

0022-2623

issn

1520-4804

journal_volume

56

pub_type

杂志文章,评审

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