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Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives.

Abstract：

:In order to find a new class of anti-Helicobacter pylori (H. pylori) agents, a series of 4-[(3-acetamido)phenyl]-2-(substituted guanidino)thiazoles and some structurally rigid analoges were synthesized and evaluated for antimicrobial activity against H. pylori. Among the compounds obtained, high anti-H. pyrori activities were observed in benzyl derivative 34 (MIC = 0.025 microg/mL) and phenethyl derivatives 35 and 36 (MIC = 0.037 microg/mL and 0.017 microg/mL). Though alkyl derivatives generally showed lower activity, the 2-methoxyethyl derivative 28 preserved significant activity (MIC = 0.32 microg/mL) and also exhibited more potent gastric antisecretory activity than ranitidine. Structural restriction by bridging between the thiazole and the phenyl rings with an alkyl chain did not improve the activity in this series.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Katsura Y,Tomishi T,Inoue Y,Sakane K,Matsumoto Y,Morinaga C,Ishikawa H,Takasugi H

doi

10.1021/jm000169n

keywords:

subject

Has Abstract

pub_date

2000-08-24 00:00:00

pages

3315-21

issue

17

eissn

0022-2623

issn

1520-4804

pii

jm000169n

journal_volume

43

pub_type

杂志文章

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