Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion.

abstract：:The autophagic ubiquitin-like protein (ublp) autophagy-related (ATG)12 is a component of the ATG12∼ATG5-ATG16L1 E3 complex that promotes lipid conjugation of members of the LC3 ublp family. A role of ATG12 in the E3 complex is to recruit the E2 enzyme ATG3. Here we report the identification of the ATG12 binding sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metlagel Z,Otomo C,Takaesu G,Otomo T

更新日期：2013-11-19 00:00:00

abstract：:Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identificat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Zheng SL,Isaacs SD,Wiley KE,Wiklund F,Sun J,Kader AK,Li G,Purcell LD,Kim ST,Hsu FC,Stattin P,Hugosson J,Adolfsson J,Walsh PC,Trent JM,Duggan D,Carpten J,Grönberg H,Isaacs WB

更新日期：2010-02-02 00:00:00

abstract：:The theory of "top-down" ecological regulation predicts that herbivory suppresses plant abundance, biomass, and survival but increases diversity through the disproportionate consumption of dominant species, which inhibits competitive exclusion. To date, these outcomes have been clear in aquatic ecosystems but not on l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jia S,Wang X,Yuan Z,Lin F,Ye J,Hao Z,Luskin MS

更新日期：2018-06-12 00:00:00

abstract：:Cell type in Saccharomyces yeasts is regulated by two transposable blocks of DNA, the a and alpha cassettes. There are three loci where either cassette can exist. At the HML and HMR loci the cassettes are not expressed. The cassette at the MAT locus is expressed and controls the cell type. Changes of cell type involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strathern JN,Spatola E,McGill C,Hicks JB

更新日期：1980-05-01 00:00:00

abstract：:The counterintuitive features of quantum physics challenge many common-sense assumptions. In an interferometric quantum eraser experiment, one can actively choose whether or not to erase which-path information (a particle feature) of one quantum system and thus observe its wave feature via interference or not by perfo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma XS,Kofler J,Qarry A,Tetik N,Scheidl T,Ursin R,Ramelow S,Herbst T,Ratschbacher L,Fedrizzi A,Jennewein T,Zeilinger A

更新日期：2013-01-22 00:00:00

abstract：:Graphene superlattices were shown to exhibit high-temperature quantum oscillations due to periodic emergence of delocalized Bloch states in high magnetic fields such that unit fractions of the flux quantum pierce a superlattice unit cell. Under these conditions, semiclassical electron trajectories become straight agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krishna Kumar R,Mishchenko A,Chen X,Pezzini S,Auton GH,Ponomarenko LA,Zeitler U,Eaves L,Fal'ko VI,Geim AK

更新日期：2018-05-15 00:00:00

abstract：:The quantitative autoradiographic 2-deoxy-[14C]glucose technique has been used with conscious rats to investigate the functional consequences (reflected as alterations in local rates of glucose utilization) of unilateral intrastriatal administration of vasoactive intestinal polypeptide. Intrastriatal administration of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCulloch J,Kelly PA,Uddman R,Edvinsson L

更新日期：1983-03-01 00:00:00

abstract：:Coimmunoprecipitation of members of the phytochrome red/farred photoreceptor family from plant extracts has been used to analyze their heteromeric binding interactions. Phytochrome (phy)B or phyD apoproteins with six myc epitopes fused to their N termini are biologically active when expressed in Arabidopsis. Immunopre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharrock RA,Clack T

更新日期：2004-08-03 00:00:00

abstract：:Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naeve GS,Ramakrishnan M,Kramer R,Hevroni D,Citri Y,Theill LE

更新日期：1997-03-18 00:00:00

abstract：:Mutations in Pink1, a gene encoding a Ser/Thr kinase with a mitochondrial-targeting signal, are associated with Parkinson's disease (PD), the most common movement disorder characterized by selective loss of dopaminergic neurons. The mechanism by which loss of Pink1 leads to neurodegeneration is not understood. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Gehrke S,Imai Y,Huang Z,Ouyang Y,Wang JW,Yang L,Beal MF,Vogel H,Lu B

更新日期：2006-07-11 00:00:00

abstract：:The chemosmotic model provides a framework for visualizing energy-coupled reactions (vectorial reaction sequences, membrane-dependent gradient formation, and charge separation of reacting species) and a mechanism for energy coupling (indirect coupling between the driving and driven reaction sequences mediated by a mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green DE

更新日期：1981-04-01 00:00:00

abstract：:p19ARF has been implicated as a key regulator of p53 stability and activation. While numerous stresses activate the p53 growth arrest pathway, those requiring p19ARF remain to be elucidated. We used p19ARF knockout mouse embryo fibroblasts to show that DNA damage and microtubule disruption require p19ARF to induce p53...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan SH,Moritsugu J,Wahl GM

更新日期：2000-03-28 00:00:00

abstract：:Mutant forms of the BRCA2 gene contribute significantly to hereditary breast cancer. Isolation of the normal and mutant forms of the BRCA2 gene with its natural promoter would greatly facilitate analysis of the gene and its contribution to breast cancer. We have accomplished the direct isolation of the 90-kb gene from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larionov V,Kouprina N,Solomon G,Barrett JC,Resnick MA

更新日期：1997-07-08 00:00:00

abstract：:The circular dichroism of hypothetical, water-filled, spherical shells, 75-3500 nm in radius, with walls 7.5 nm thick, composed of poly(L-lysine) in various conformational proportions, and suspended in water, were computed from the known optical properties of this polypeptide by classical general light-scattering theo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallach DF,Low DA,Bertland AV

更新日期：1973-11-01 00:00:00

abstract：:Unprecedented population declines and extinctions because of human activities, combined with a growing recognition that such losses affect the stability of ecosystems, underscore the need to better understand how populations persist naturally. We provide field experimental evidence that high biodiversity-in particular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carr MH,Anderson TW,Hixon MA

更新日期：2002-08-20 00:00:00

abstract：:Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated "parthanatos" in which PAR induces the mitochondrial release and nuclear translocation of apoptosis-inducing factor to initiate chromatinolysis and cell death. Accompanying the formation of PAR are the red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrabi SA,Umanah GK,Chang C,Stevens DA,Karuppagounder SS,Gagné JP,Poirier GG,Dawson VL,Dawson TM

更新日期：2014-07-15 00:00:00

abstract：:This paper describes the state of the art in applications of voice-processing technologies. In the first part, technologies concerning the implementation of speech recognition and synthesis algorithms are described. Hardware technologies such as microprocessors and DSPs (digital signal processors) are discussed. Softw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakatsu R,Suzuki Y

更新日期：1995-10-24 00:00:00

abstract：:Heparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting in disassembly of the extracellular matrix underlying endothelial and epithelial cells and associating with enhanced cell invasion and metastasis. Heparanase expression is induced in carcinomas and sarcomas, often ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissmann M,Arvatz G,Horowitz N,Feld S,Naroditsky I,Zhang Y,Ng M,Hammond E,Nevo E,Vlodavsky I,Ilan N

更新日期：2016-01-19 00:00:00

abstract：:In most organisms, light plays a key role in the synchronization of the circadian timing system with the environmental day-night cycle. Light pulses that phase-shift the circadian clock also induce the expression of period (per) genes in vertebrates. Here, we report the cloning of a zebrafish per gene, zfper4, which i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vallone D,Gondi SB,Whitmore D,Foulkes NS

更新日期：2004-03-23 00:00:00

abstract：:The apparatus of photosynthetic energy conversion in chloroplasts is quite well characterized with respect to structure and function. Light-driven electron transport in the thylakoid membrane is coupled to synthesis of ATP, used to drive energy-dependent metabolic processes in the stroma and the outer surface of the t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spetea C,Hundal T,Lundin B,Heddad M,Adamska I,Andersson B

更新日期：2004-02-03 00:00:00

abstract：:Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats do not develop arthritis in response to the same SCW stimulus. To evaluate this difference in inflammat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternberg EM,Hill JM,Chrousos GP,Kamilaris T,Listwak SJ,Gold PW,Wilder RL

更新日期：1989-04-01 00:00:00

abstract：:Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seybold BA,Stanco A,Cho KK,Potter GB,Kim C,Sohal VS,Rubenstein JL,Schreiner CE

更新日期：2012-08-21 00:00:00

abstract：:We have previously identified a generally occurring short-range mobility of nucleosome cores on DNA in relatively low ionic strength conditions. Here we report that this mobility of histone octamers positioned on constructs of 5S rDNA is suppressed by the binding of histone H1 or H5 to the nucleosome. Histone H5 is th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pennings S,Meersseman G,Bradbury EM

更新日期：1994-10-25 00:00:00

abstract：:Microtubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongation and shortening, particularly at the more dynamic plus-end. Microtubule plus-end tracking proteins (+TIPs) localize to and track with growing microtubule plus-ends in the cell. +TIPs regulate microtubule dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dixit R,Barnett B,Lazarus JE,Tokito M,Goldman YE,Holzbaur EL

更新日期：2009-01-13 00:00:00

abstract：:Atmospheric models generally assume that aerosol particles are in equilibrium with the surrounding gas phase. However, recent observations that secondary organic aerosols can exist in a glassy state have highlighted the need to more fully understand the kinetic limitations that may control water partitioning in ambien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bones DL,Reid JP,Lienhard DM,Krieger UK

更新日期：2012-07-17 00:00:00

abstract：:The ras oncogene products require membrane localization for their function, and this is thought to be accomplished by the addition of a palmitoyl group to a cysteine residue near the carboxyl terminus of the nascent chain. A lipidated carboxyl-terminal cysteine residue is also found in sequence-related yeast sex facto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clarke S,Vogel JP,Deschenes RJ,Stock J

更新日期：1988-07-01 00:00:00

abstract：:Type-1 reactions (T1R) are pathological inflammatory episodes and main contributors to nerve damage in leprosy. Here, we evaluate the genewise enrichment of rare protein-altering variants in 7 genes where common variants were previously associated with T1R. We selected 474 Vietnamese leprosy patients of which 237 were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fava VM,Xu YZ,Lettre G,Van Thuc N,Orlova M,Thai VH,Tao S,Croteau N,Eldeeb MA,MacDougall EJ,Cambri G,Lahiri R,Adams L,Fon EA,Trempe JF,Cobat A,Alcaïs A,Abel L,Schurr E

更新日期：2019-07-30 00:00:00

abstract：:Natural antimicrobial peptides (AMPs) provide prototypes for the design of unconventional antimicrobial agents. Existing bulk assays measure AMP activity but do not provide details of the growth-halting mechanism. We use fluorescence microscopy to directly observe the attack of the human antimicrobial peptide LL-37 on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sochacki KA,Barns KJ,Bucki R,Weisshaar JC

更新日期：2011-04-19 00:00:00

abstract：:It is well established that assimilatory nitrate reductase (ANR) activity in soil is inhibited by ammonium (NH4+). To elucidate the mechanism of this inhibition, we studied the effect of L-methionine sulfoximine (MSX), an inhibitor of NH4+ assimilation by microorganisms, on assimilatory reduction of nitrate (NO3-) in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCarty GW,Bremner JM

更新日期：1992-01-15 00:00:00

abstract：:The 8;21 translocation is one of the most common specific rearrangements in acute myelogenous leukemia. We have identified markers (D21S65 and a Not I boundary clone, Not-42, referred to as probe B) flanking the chromosome 21 translocation breakpoint (21q22.3) that demonstrate physical linkage in normal genomic DNA, b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao J,Erickson P,Gardiner K,Le Beau MM,Diaz MO,Patterson D,Rowley JD,Drabkin HA

更新日期：1991-06-01 00:00:00