Abstract：
:Alcohol causes different hematologic alterations on each of the three bone marrow cellular series. Its effect on the red series leads to the appearance of megaloblastic disturbances, erythroblastic vacuolization, iron metabolism abnormalities, and hemolytic syndromes. Megaloblastic disturbances may arise as a consequence of folic acid or vitamin B12 deficiency or of a direct toxic effect of ethanol on the erythroblasts. Iron metabolism alterations include reversible sideroblastic anemia, and hemosiderosis. The three hemolytic syndromes related to the consumption of ethanol are: acanthocytosis, stomatocytosis, and Zieve's syndrome. Alcohol induces leukopenia and functional deffects of the leukocytes; these facts explain the frequent susceptibility of chronic alcoholics to infection. Ethanol may act upon the megakaryocytic series to produce reversible thrombopenia and various alterations in platelet function. Thus alcohol exerts toxic effects on bone marrow, which interfere with the proliferation, maturation, release and survival of the three cellular series, either directly or by means of complex mechanisms related to the metabolism of folic acid, vitamin B12, pyridoxine, or iron. Alcoholism should therefore be considered as a possible cause whenever an obscure hematological condition comes under scrutiny.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Alvarez-Sala Walther JL,Urbán Poza MA,Sicilia de Salamanca JJ,Fernández Mendieta F,Serrano Heranz R,Espinós Pérez Dsubject
Has Abstractpub_date
1979-02-25 00:00:00pages
158-65issue
4eissn
0025-7753issn
1578-8989journal_volume
72pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：:The characteristics of previous potentials of somatosensory evoked potential in 12 patients with lesions of the brain-stem and in 24 normal individuals have been studied. Lesions of the brain-stem were confirmed by means of computerized axial tomography, arteriography or necropsy. According to data reported by other a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-09-25 00:00:00
abstract：BACKGROUND:We describe the cytogenetic results of 93 patients with myelodysplastic syndromes (MDS). The main object of this report is to analyze the prognostic value of the karyotype in patients with MDS, in relation to the evolution to acute leukemia and the survival time. PATIENTS AND METHODS:Cytogenetic studies wer...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-01-31 00:00:00
abstract：:Multiple sclerosis occurs in genetically susceptible individuals, in whom an unknown environmental factor triggers an immune response, giving rise to a chronic and disabling autoimmune disease. Currently, significant progress is being made in our knowledge of the frequency and distribution of multiple sclerosis and it...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(15)30010-5
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13106675
更新日期：2007-06-02 00:00:00
abstract：:Autoinflammatory syndromes are characterised by recurrent or persistent inflammation with no increase in the antibody titers or antigen-specific T lymphocytes, and absence of infection. Initially, they included the hereditary periodic fever syndromes, a group of innate immune system monogenic diseases characterised by...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(11)70002-1
更新日期：2011-01-01 00:00:00
abstract：:The case of a 31 year-old intravenous drug addict female patient with infection by the human immunodeficiency virus who had recurrent cardiac tamponade and who was diagnosed by pericardic biopsy as Kaposi's sarcoma is reported. The patient demonstrated involvement by cutaneous, mucosal, lymph node and probably pleurop...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-04-09 00:00:00
abstract：:We report the case of a female aged 67 years suffering a Waldenström's macroglobulinemia which began with arthritis at the knee and pleural effusion. In both locations the anatomopathological examination showed infiltration by typical lympho-plasmatic cells. Other possible etiologies such as amyloid, infection or arth...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1990-10-27 00:00:00
abstract：BACKGROUND:Description of measures of secondary prevention and of health related quality of life one year after the intervention in patients undergoing coronary artery bypass surgery. PATIENTS AND METHOD:One year follow up prospective study in patients undergoing first coronary bypass surgery without associated proced...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71785-x
更新日期：2001-02-24 00:00:00
abstract：:The decision-making process includes a series of activities undertaken in biomedical journals from the moment a manuscript is received until it is accepted or rejected. Firstly, the manuscript is evaluated by the members of the Editorial Board, who analyze both its suitability for the journal and its scientific qualit...
journal_title：Medicina clinica
pub_type： 指南,杂志文章
doi：10.1016/s0025-7753(05)72202-8
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:With the aim of studying the characteristics of the use of digoxin in a population which attended a hospital emergency department for heart failure or auricular fibrillation a 3 month observational study was carried out in the emergency department of the Ciudad Sanitaria de la Vall d'Hebron. METHODS:One hun...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-01-23 00:00:00
abstract：:Hemolytic disease by cold-reacting antibodies is a rare form of hemolytic anemia. In most cases a subjacent cause is found. This disease is generally related with reactive lymphoproliferative processes (infections by the Epstein-Barr virus and cytomegalovirus) or uncontrolled lymphoproliferative disorders (lymphomas, ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-04-04 00:00:00
abstract：:The case of a 19 year old patient with Takayasu arteritis with exclusive involvement of the abdominal aorta and without involvement of the renal arteries who presented severe arterial hypertension during the acute phase of the disease is referred. The administration of a dose of 20 mg of enalapril maleate was followed...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-22 00:00:00
abstract：BACKGROUND:Whether or not performing cardiopulmonary resuscitation (CPR) is a complex decision that requires taking account of several factors. The aim of this study was to analyse the preferences of elderly people with regard to CPR. SUBJECTS AND METHOD:Survey administered to 181 elderly subjects from nursing homes a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)72296-3
更新日期：2002-02-02 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The proportion of elderly patients hospitalized in acute care wards has progressively increased. Patients with a decreased functional status are prone to have malnutrition which negatively affects their prognosis and increases mortality. However, it is unclear whether functional and nutritional...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(04)74521-2
更新日期：2004-09-25 00:00:00
abstract：BACKGROUND:A right information about illness is essential if a patient has to take ethically autonomous medical decisions. We assessed whether a group o patients with chronic obstructive pulmonary disease (COPD) had enough information about their illness to take medical decisions. PATIENTS AND METHOD:Structured interv...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71896-9
更新日期：2001-04-21 00:00:00
abstract：:The coexistence of organ-specific and nonorgan-specific autoimmune diseases is an interesting phenomenon. A 52-year-old woman was admitted with fever, general discomfort, polyarthritis, and Raynaud's phenomenon. Physical examination revealed a goiter of stony consistency, hardening, paleness, and atrophy of the skin o...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-11-10 00:00:00
abstract：BACKGROUND:We have examined the variation in the promoter region in the gene encoding UGT-1, associated with Gilbert's syndrome, in Spanish population. PATIENTS AND METHOD:Blood DNA was obtained from 100 blood donors. Polymerase chain reaction (PCR) was used to examine the A(TA)nTAA motif in the promoter region of the...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2000-10-28 00:00:00
abstract：BACKGROUND:The values of the squamous cell carcinoma (SCC) antigen in benign diseases were studied with the aim of determining false positive values in the study of epidermoid carcinomas. METHODS:Serum determinations of the SCC antigen were performed by radioimmunoanalysis with the Abbott SCC-RIA kit. The control grou...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-02-17 00:00:00
abstract：:A group of 39 patients has been divided in three categories according to their plasmatic renine activity and the correlation of the hipotensive answer to the Timolol Maleate (betadrenergic blocking). The control is more favourable in the normorreninemic than in the hiporreninemic patients and, paradoxically, even more...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-09-10 00:00:00
abstract：BACKGROUND:The annual consumption and costs of the health care resources used by ambulatory Alzheimer's disease patients were estimated. Patients were classified according to the degree of severity of the disease using Folstein's Mini Mental State Examination scale. The sociodemographic characteristics of both patients...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1999-11-27 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Among nosocomial infections, pneumonia is one of the most important ones due to the mortality, morbidity and the increase of costs that it causes. The implementation of a cost-effective surveillance system for these infections is a challenge for hospitals. The objective of this work was to eval...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13070453
更新日期：2005-01-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The impact and burden of disease of the rare diseases (RD) is not known, also the type of disability that entail. The objective of the work is to analyze the socio-sanitary impact of the RD in Spain. PATIENTS AND METHOD:This is a nationwide study. The dimensions used were mobility, personal ca...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13112096
更新日期：2007-11-10 00:00:00
abstract：:Three cases of encrusted cystitis caused by Corynebacterium group D2 are described. The vesical damage previous to the establishment of this bacteria is noteworthy and the very rapid increase in urease activity explains the pathogenesis of the situation. Thus allowing for its identification and is relevant to treatmen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-21 00:00:00
abstract：BACKGROUND:The aim of the present study was to obtain information about tuberculosis (TB) in our area that might contribute to assess the status in Spain. METHODS:A meticulous case finding was carried out during 1988 in all the hospitals of the Gran Canaria island. RESULTS:214 cases were found (rate 32.2) and 77% wer...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of the present study was to investigate the factors influencing CRP serum levels in the diabetic population. PATIENTS AND METHOD:Eighty-six patients with type 2 diabetes mellitus were prospectively included. The following variables were considered: age, gender, smoking habit, body mass...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13072422
更新日期：2005-03-12 00:00:00
abstract：:A prospective analysis was carried out to evaluate the cost-effectiveness of two alternatives for the treatment of hypo-agammaglobulinemia with intravenous immunoglobulin: the current hospital administration and the administration in the patient's home. 38 patients or relatives were surveyed about their personal or fa...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-01-19 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of our study was to identify the rate of diabetic patients treated for hypothyroidism and compare them with a group without type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:We reviewed the computerized clinical records of 5161 patients. We identified diabetic patients treated with...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2011.08.009
更新日期：2012-04-28 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Obesity is characterized by a generalized increase of adipose tissue, high production of adipocytokines and presence of oxidative systemic stress. The objective of this study was to evaluate the changes generated in the oxidative stress and anthropometric parameters in obese subjects by the pre...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.12.015
更新日期：2015-07-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Since World Health Organization (WHO) recommends brief interventions for smoking cessation to be included systematically in daily practise as a part of clinical work, the main aim of this study is to know if this intervention is done by health professionals working in hospital wards in a genera...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13106128
更新日期：2007-05-19 00:00:00
abstract：BACKGROUND:Group therapy is a widely used technique for the treatment of tobacco, alcohol and other toxic addictions. Nevertheless, its effectiveness for smoking cessation remains to be established. Our objective was to evaluate the relative effectiveness of a group intervention versus an individual intervention for sm...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0025-7753(02)73312-5
更新日期：2002-06-15 00:00:00
