Comparison of leukocytes obtained from the intestinal lumen of Giardia-infected immunocompetent mice and nude mice.

abstract：BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...

journal_title：Gastroenterology

authors： Tremolaterra F,Villoria A,Azpiroz F,Serra J,Aguadé S,Malagelada JR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND/AIMS:Both hemorrhagic and cardiogenic shock are associated with hepatic shock gene expression at resuscitation. This study investigated the potential role of intravascular superoxide anion as a proximal trigger of heat shock protein gene expression. METHODS:Preanesthetized pigs were subjected to 120 m of to...

journal_title：Gastroenterology

authors： Schoeniger LO,Andreoni KA,Ott GR,Risby TH,Bulkley GB,Udelsman R,Burdick JF,Buchman TG

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND & AIMS:People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hod...

journal_title：Gastroenterology

authors： Persson EC,Shiels MS,Dawsey SM,Bhatia K,Anderson LA,Engels EA

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:ob/ob mice are used to study the mechanisms that regulate the progression from steatosis to nonalcoholic steatohepatitis. The livers of ob/ob mice are depleted of CD4-positive natural killer cells, components of the innate immune system that induce anti-inflammatory cytokines. Although this may explai...

journal_title：Gastroenterology

authors： Li Z,Lin H,Yang S,Diehl AM

更新日期：2002-10-01 00:00:00

abstract：:A case of primary liver cell carcinoma is presented in which tumor emboli to the pulmonary microvasculature resulted in pulmonary hypertension, documented by clinical, radiologic, electrocardiographic, and cardiac catheter studies. Emboli arose from tumor invading the portal vein and passed via a patent splenorenal sh...

journal_title：Gastroenterology

authors： Willett IR,Sutherland RC,O'Rourke MF,Dudley FJ

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND & AIMS:Senescence prevents cellular transformation. We investigated whether vascular endothelial growth factor (VEGF) signaling via its receptor, VEGFR2, regulates senescence and proliferation of tumor cells in mice with colitis-associated cancer (CAC). METHODS:CAC was induced in VEGFR2(ΔIEC) mice, which do...

journal_title：Gastroenterology

authors： Foersch S,Sperka T,Lindner C,Taut A,Rudolph KL,Breier G,Boxberger F,Rau TT,Hartmann A,Stürzl M,Wittkopf N,Haep L,Wirtz S,Neurath MF,Waldner MJ

更新日期：2015-07-01 00:00:00

abstract：:A numerically important group of patients with functional gastrointestinal disorders have chronic symptoms that can be attributed to the gastroduodenal region. Based on the consensus opinion of an international panel of clinical investigators who reviewed the available evidence, a classification of the functional gast...

journal_title：Gastroenterology

authors： Tack J,Talley NJ,Camilleri M,Holtmann G,Hu P,Malagelada JR,Stanghellini V

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown that intestinal manipulation leads to a significant inhibition of circular muscle contraction. We hypothesized that the inflammatory mediator inducible nitric oxide (NO) plays a role in surgically induced ileus. METHODS:Rats and inducible NO synthase (iNOS) knockout and wild-type mice u...

journal_title：Gastroenterology

authors： Kalff JC,Schraut WH,Billiar TR,Simmons RL,Bauer AJ

更新日期：2000-02-01 00:00:00

abstract：:Colchicine treatment was used in this randomized placebo-controlled trial in patients with severe acute alcoholic hepatitis [serum bilirubin greater than or equal to 5 mg/dL (85.5 mumol/L) mean, 17.5 +/- 7.5 mg/dL (299.25 +/- 128.25 mumol/L)]. Hospitalization mortality and morbidity and the effect on biochemical test ...

journal_title：Gastroenterology

authors： Akriviadis EA,Steindel H,Pinto PC,Fong TL,Kanel G,Reynolds TB,Gupta S

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND/AIMS:Ursodeoxycholic acid (UDCA) and colchicine have beneficial effects in primary biliary cirrhosis (PBC). The efficacy of colchicine and UDCA in PBC was compared in a 2-year placebo-controlled study (n = 90). METHODS:Clinical events, laboratory test results, and liver histology were recorded at the beginn...

journal_title：Gastroenterology

authors： Vuoristo M,Färkkilä M,Karvonen AL,Leino R,Lehtola J,Mäkinen J,Mattila J,Friman C,Seppälä K,Tuominen J

更新日期：1995-05-01 00:00:00

abstract：:Sweden has one of the highest incidences of gallstone disease in the Western world. It is therefore important to characterize the mechanisms responsible for the formation of cholesterol gallstones in this population. In the present study, we have determined the kinetics of the two primary bile acids, cholic acid and c...

journal_title：Gastroenterology

authors： Nilsell K,Angelin B,Liljeqvist L,Einarsson K

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND & AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been implicated in diverticular complications. We examined the influence of aspirin and NSAID use on risk of diverticulitis and diverticular bleeding in a large prospective cohort. METHODS:We studied 47,210 US men in the Health Pr...

journal_title：Gastroenterology

authors： Strate LL,Liu YL,Huang ES,Giovannucci EL,Chan AT

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Patients affected by familial adenomatous polyposis (FAP) are at increased risk of developing duodenal adenomas. In this study, cell proliferation of duodenal mucosa was analyzed to detect kinetic abnormalities related to cancer risk. METHODS:Duodenal biopsy specimens were collected in three groups o...

journal_title：Gastroenterology

authors： Santucci R,Volpe L,Zannoni U,Paganelli GM,Poggi B,Calabrese C,Biasco G

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND & AIMS:The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown. METHODS:Individuals aged 50-74 years living in Southeast Norway were randomly invited between 2012 and 2019 to either once-only flexible sigmoidoscopy or FIT screeni...

journal_title：Gastroenterology

authors： Randel KR,Schult AL,Botteri E,Hoff G,Bretthauer M,Ursin G,Natvig E,Berstad P,Jørgensen A,Sandvei PK,Olsen ME,Frigstad SO,Darre-Næss O,Norvard ER,Bolstad N,Kørner H,Wibe A,Wensaas KA,de Lange T,Holme Ø

更新日期：2020-11-21 00:00:00

abstract：:The management of colon polyps has been completely revolutionized since the introduction of colonoscopic polypectomy. The reductions in patient time, cost, morbidity, and mortality are major advantages. Reported complications include primarily hemorrhage (1.7%) and frank clinical perforation (0.32%). This report descr...

journal_title：Gastroenterology

authors： Overholt BF,Hargrove RL,Farris RK,Wilson BM

更新日期：1976-01-01 00:00:00

abstract：:Interstitial pneumonitis is an uncommon complication of low-dose methotrexate therapy in patients with psoriasis but occurs in 3%-5% of patients with rheumatoid arthritis. We found a higher incidence of interstitial pneumonitis in patients with primary biliary cirrhosis (14%) and describe its clinical manifestations, ...

journal_title：Gastroenterology

authors： Sharma A,Provenzale D,McKusick A,Kaplan MM

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:Growth, progression, and drug resistance of pancreatic ductal adenocarcinomas (PDACs) have been associated with increased levels and activity of glycogen synthase kinase 3 beta (GSK3B) and histone deacetylases (HDACs). We designed and synthesized molecules that simultaneously inhibit the activities of...

journal_title：Gastroenterology

authors： Edderkaoui M,Chheda C,Soufi B,Zayou F,Hu RW,Ramanujan VK,Pan X,Boros LG,Tajbakhsh J,Madhav A,Bhowmick NA,Wang Q,Lewis M,Tuli R,Habtezion A,Murali R,Pandol SJ

更新日期：2018-12-01 00:00:00

abstract：:Three analogues of the carboxyl-terminal tricosapeptide of secretin (S5-27), one with glutamine replacing glutamic acid in position 9 (9-Gln-S5-27), a second with asparagine substituted for aspartic acid in position 15 (15-Asn-S5-27), and a third with both replacements (9-Gln-15-Asn-S5-27) were tested for their abilit...

journal_title：Gastroenterology

authors： Gardner JD,Conlon TP,Fink ML,Bodanszky M

更新日期：1976-12-01 00:00:00

abstract：:Flow cytometry was used to detect the presence and assess the distribution of aneuploid cell populations in eight proctocolectomy specimens from patients with ulcerative colitis. Mucosal samples were taken according to a systematic protocol for flow cytometry, the surrounding tissue was examined histologically, and th...

journal_title：Gastroenterology

authors： Levine DS,Rabinovitch PS,Haggitt RC,Blount PL,Dean PJ,Rubin CE,Reid BJ

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Cholestasis is one of the principal manifestations of liver disease and often results from disorders involving bile duct epithelia rather than hepatocytes. A range of disorders affects biliary epithelia, and no unifying pathophysiologic event in these cells has been identified as the cause of choles...

journal_title：Gastroenterology

authors： Shibao K,Hirata K,Robert ME,Nathanson MH

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND & AIMS:The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity is created within the embryonic ENS; information required for development of cell-based therapies and models of enteric ...

journal_title：Gastroenterology

authors： Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundström E,Pachnis V,Marklund U

更新日期：2018-02-01 00:00:00

abstract：:The effect of deoxycholate ingestion, 750 mg per day, on bile acid kinetics, biliary bile acid composition, and biliary lipid secretion was studied in 7 healthy volunteers. Bile acid kinetics were measured by isotope dilution, and hourly outputs of bile acid, cholesterol, and phospholipid were quantitated by a duodena...

journal_title：Gastroenterology

authors： LaRusso NF,Szczepanik PA,Hofmann AF

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...

journal_title：Gastroenterology

authors： Fletcher J,Wirz A,Young J,Vallance R,McColl KE

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND & AIMS:One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing, whereas the low concentration in normal human cells decreases sid...

journal_title：Gastroenterology

authors： Abe T,Unno M,Onogawa T,Tokui T,Kondo TN,Nakagomi R,Adachi H,Fujiwara K,Okabe M,Suzuki T,Nunoki K,Sato E,Kakyo M,Nishio T,Sugita J,Asano N,Tanemoto M,Seki M,Date F,Ono K,Kondo Y,Shiiba K,Suzuki M,Ohtani H,S

更新日期：2001-06-01 00:00:00

abstract：:Interleukin 2, a soluble product of activated T lymphocytes, is of central importance in the development of an appropriate T-cell immune response. Defects in the production of or response to this lymphokine have been described in a variety of immune deficiency and autoimmune states, thus suggesting a role in the patho...

journal_title：Gastroenterology

authors： Fiocchi C,Hilfiker ML,Youngman KR,Doerder NC,Finke JH

更新日期：1984-04-01 00:00:00

abstract：:To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...

journal_title：Gastroenterology

authors： Yasuura S,Ueno T,Watanabe S,Hirose M,Namihisa T

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Epithelial stem cells in the stomach are responsible for constant renewal of the epithelium through generation of multiple gastric cell lineages that populate the gastric glands. However, gastric stem or progenitor cells have not been well-characterized because of the lack of specific markers that per...

journal_title：Gastroenterology

authors： Qiao XT,Ziel JW,McKimpson W,Madison BB,Todisco A,Merchant JL,Samuelson LC,Gumucio DL

更新日期：2007-12-01 00:00:00

abstract：:Intestinal mucin and goblet cells were examined in streptozotocin-diabetic rats and age-matched controls. Mucin (tissue content and secretion) was measured using a highly specific enzyme-linked immunoassay. In contrast to the increased protein to deoxyribonucleic acid ratio, an absolute decrease was observed in the mu...

journal_title：Gastroenterology

authors： Mantle M,Thakore E,Atkins E,Mathison R,Davison JS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:According to the National Center for Health Statistics (NCHS), chronic liver disease and cirrhosis is the 12(th) leading cause of death in the United States. However, this single descriptor might not adequately enumerate all deaths from liver disease. The aim of our study was to update data on liver m...

journal_title：Gastroenterology

authors： Asrani SK,Larson JJ,Yawn B,Therneau TM,Kim WR

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Nitric oxide acts as a neurotransmitter of nonadrenergic, noncholinergic pathways. The present study examined the role of the L-arginine/NO pathway on sphincter of Oddi motility. METHODS:In anesthetized guinea pigs and rabbits, intracholedochal pressure was recorded by a perfused catheter whose open tip was...

journal_title：Gastroenterology

authors： Mourelle M,Guarner F,Moncada S,Malagelada JR

更新日期：1993-11-01 00:00:00