Abstract:
:The structure and function of the apolipoproteins are of interest because of their central role in lipid metabolism. We report the complete primary structure of the human apo AII and CIII genes. These, like apo AI, contain three introns located at conserved positions. This may reflect their evolutionary and functional relationship. Indeed, computer-aided analysis shows that these apolipoproteins and apo AIV (rat), CI, CII and E contain homologous amino acid sequences. In the case of apo AI, AII and CIII, such sequences are encoded by equivalent exons. Finally, the apo AII gene presents a unique intron-exon junction sequence 5' (G-T)16G-G-G-C-A-G 3' that, although departing considerably from the accepted consensus (Py)15X-Py-A-G, appears to function efficiently both in vivo and in a transient expression system.
journal_name
J Mol Bioljournal_title
Journal of molecular biologyauthors
Shelley CS,Sharpe CR,Baralle FE,Shoulders CCdoi
10.1016/0022-2836(85)90255-4subject
Has Abstractpub_date
1985-11-05 00:00:00pages
43-51issue
1eissn
0022-2836issn
1089-8638pii
0022-2836(85)90255-4journal_volume
186pub_type
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