Enhancement of noradrenaline release by 12-O-tetradecanoyl phorbol-13-acetate, an activator of protein kinase C.

abstract：:The pharmacological actions of sotalol, (-)-propranolol and prazosin on norepinephrine (NE) concentration and creatine kinase (CK) activity in the coronary sinus blood of the ischemic heart were studied in open-chest dogs. A 60 min occlusion of the left anterior descending coronary artery was followed by a reperfusion...

journal_title：European journal of pharmacology

authors： Lamontagne D,Yamaguchi N,Nadeau R,De Champlain J,Godin D,Campeau N

更新日期：1986-04-09 00:00:00

abstract：:The involvement of dopamine D-1 and D-2 receptor mechanisms was investigated in the forced swimming test with rats. d,1-Sulpiride, a D-2 receptor antagonist, reported to reduce desipramine-induced anti-immobility, did not alter the brain levels of desipramine. In addition, the anti-immobility effect of desipramine was...

journal_title：European journal of pharmacology

authors： Borsini F,Lecci A,Mancinelli A,D'Aranno V,Meli A

更新日期：1988-04-13 00:00:00

abstract：:The effects on rat serum prolactin level of the two isomers constituting the racemic form of amisulpride were compared. (S-)-amisulpride induced hyperprolactinemia at lower doses (ED(50) = 0.09 +/- 0.01 mg/kg) than racemic- (ED(50) = 0.24 +/- 0.03 mg/kg) and (R+)-amisulpride (ED(50) = 4.13 +/- 0.05 mg/kg), in accord w...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Saba P,Gessa GL,Pani L

更新日期：2002-07-19 00:00:00

abstract：:σ2 Receptor subtype is overexpressed in a variety of human tumors, with σ2 agonists showing antiproliferative effects towards tumor cells through multiple pathways that depend both on the tumor cell type and on the molecule type. Therefore, σ2 receptor is an intriguing target for tumor diagnosis and treatment despite ...

journal_title：European journal of pharmacology

authors： Abate C,Niso M,Infantino V,Menga A,Berardi F

更新日期：2015-07-05 00:00:00

abstract：:Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase), and tynorphin has been synthesized as a more potent inhibitor of dipeptidyl aminopeptidase III. In this s...

journal_title：European journal of pharmacology

authors： Yamazaki T,Honda M,Yamamoto Y,Hazato T,Ono H

更新日期：2001-02-16 00:00:00

abstract：:Resveratrol has been purported to modify risk factors for obesity and cardiovascular disease. We sought to examine the effects of resveratrol in a porcine model of metabolic syndrome and chronic myocardial ischemia. Yorkshire swine were fed either a normal diet (control), a high cholesterol diet (HCD), or a high chole...

journal_title：European journal of pharmacology

authors： Robich MP,Osipov RM,Chu LM,Han Y,Feng J,Nezafat R,Clements RT,Manning WJ,Sellke FW

更新日期：2011-08-16 00:00:00

abstract：:Oenanthotoxin (OETX) and dihydro-OETX are polyacetylenic diols occurring in Oenanthe crocata and are known to exert proconvulsant effects. We have recently demonstrated that these compounds downregulated GABAergic currents (Appendino et al., 2009) and that OETX induced open channel block and allosterically modulated G...

journal_title：European journal of pharmacology

authors： Wyrembek P,Negri R,Appendino G,Mozrzymas JW

更新日期：2012-05-15 00:00:00

abstract：:To test the hypothesis that the flavonoid compound, fisetin, protects macrophages from lipid accumulation and senescence through regulation of casein kinase 2-interacting protein-1 (CKIP-1)/REGγ (11S regulatory particles, 28 kDa proteasome activator, proteasome activator subunit 3) signaling. RAW264.7 macrophage cells...

journal_title：European journal of pharmacology

authors： Jia Q,Cao H,Shen D,Yan L,Chen C,Xing S

更新日期：2019-12-15 00:00:00

abstract：:Non-peptide antagonists of the NK1 and NK2 receptors were tested as inhibitors of the reaction time in the rat tail-flick and on the decrease of reaction time induced by the intrathecal injection of the NK1 receptor selective agonist [Sar9,Met(O2)11]SP or of the NK2 selective agonist NKA-(4-10). The decrease in reacti...

journal_title：European journal of pharmacology

authors： Picard P,Boucher S,Regoli D,Gitter BD,Howbert JJ,Couture R

更新日期：1993-03-02 00:00:00

abstract：:Characteristics of muscarinic receptors were investigated in circular muscle from normal human colon. In saturation studies (n=18), binding of [3H]quinuclidinyl benzylate (QNB) was of high affinity (K(d) 87.3 pM) and capacity (B(max) 362+/-27 fmol/mg protein), with no differences between ascending and sigmoid colon. K...

journal_title：European journal of pharmacology

authors： Mansfield KJ,Mitchelson FJ,Moore KH,Burcher E

更新日期：2003-12-15 00:00:00

abstract：:Intake of nicotine has been related in many cases to acute or chronic hypertension. Using the patch-clamp technique the effect of nicotine on voltage-dependent K+ channel currents in rat tail artery smooth muscle cells was studied. Nicotine at concentrations of 1-100 microM or 0.3-3 mM increased or decreased, respecti...

journal_title：European journal of pharmacology

authors： Tang G,Hanna ST,Wang R

更新日期：1999-01-08 00:00:00

abstract：:The effect of prolonged administration of high doses of buspirone on its 5-hydroxytryptamine (5-HT) release-inhibitory and anxiolytic-like properties was investigated. The 5-HT release-inhibitory effect of a challenge dose of buspirone (0.5 mg/kg, s.c.) was identical in rats chronically treated with vehicle or buspiro...

journal_title：European journal of pharmacology

authors： Söderpalm B,Lundin B,Hjorth S

更新日期：1993-08-03 00:00:00

abstract：:In the present study, we investigated whether copper ions are involved in the decomposition of endogenous S-nitrosothiols by ultraviolet (UV) light irradiation in the mouse gastric fundus. The effects of copper ions and chelators of copper(I) and copper(II), neocuproine and cuprozine, respectively, were studied on rel...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2004-02-06 00:00:00

abstract：:The goal of this report is to present the results obtained with three new GABAB receptor antagonists. CGP 54062 has an IC50 in a GABAB binding test of 0.013 microM which is roughly 2500-fold lower than one of the most potent blockers known so far, CGP 35348 (IC50 = 34 microM). CGP 46381 and CGP 36742 have IC50s of 4.9...

journal_title：European journal of pharmacology

authors： Olpe HR,Steinmann MW,Ferrat T,Pozza MF,Greiner K,Brugger F,Froestl W,Mickel SJ,Bittiger H

更新日期：1993-03-23 00:00:00

abstract：:The breakdown of inositol phospholipid (PI) stimulated by hippocampal noradrenaline in rat miniprisms in vitro was used as an index of alpha 1-adrenoceptor function after selective noradrenergic denervation. Selective denervation was produced by microinjections of 6-hydroxydopamine (6-OHDA) into either the dorsal nora...

journal_title：European journal of pharmacology

authors： Fowler CJ,Magnusson O,Mohammed AK,Danysz W,Archer T

更新日期：1986-04-29 00:00:00

abstract：:Recent evidence suggests that polydatin (PD), a resveratrol glucoside, may have beneficial actions on the cardiac hypertrophy. Therefore, the current study focused on the underlying mechanism of the PD anti-hypertrophic effect in cultured cardiomyocytes and in progression from cardiac hypertrophy to heart failure in v...

journal_title：European journal of pharmacology

authors： Dong M,Ding W,Liao Y,Liu Y,Yan D,Zhang Y,Wang R,Zheng N,Liu S,Liu J

更新日期：2015-01-05 00:00:00

abstract：:The effect of regression of left ventricular hypertrophy was studied in deoxycorticosterone-acetate-salt hypertensive rats (DOCA-salt hypertensive rats) treated with tetrandrine. Treatment with tetrandrine (by gastric intubation, 50 mg/kg per day for 9 weeks) lowered systolic blood pressure, left ventricular weight, C...

journal_title：European journal of pharmacology

authors： Xu Y,Rao MR

更新日期：1995-05-04 00:00:00

abstract：:Recombinant P2X2 receptor was observed by atomic force microscope in the aqueous phase. The P2X2 receptor was expressed in an insect cell line, and recombinant proteins were prepared under native conditions. The membrane fractions were extracted, and histidine-tagged receptor protein was purified from the fractions by...

journal_title：European journal of pharmacology

authors： Nakazawa K,Yamakoshi Y,Tsuchiya T,Ohno Y

更新日期：2005-08-22 00:00:00

abstract：:Recombinant vaccinia viruses harboring the human dopamine D4 receptor cDNA containing two 48 base pair-repeats (D4.2) or the rat dopamine D2 short (D2s) receptor cDNA were used to infect rat-1 fibroblasts. Heterologous expression of both dopamine receptors was demonstrated in binding assays. The affinity constants of ...

journal_title：European journal of pharmacology

authors： Bouvier C,Bunzow JR,Guan HC,Unteutsch A,Civelli O,Grandy DK,Van Tol HH

更新日期：1995-06-23 00:00:00

abstract：:Galectins are carbohydrate-binding proteins and these have very high affinity for β-galactoside containing glycoproteins and glycolipids. Amongst sixteen types of galectin, the role of galectin 1, 3, 9 and 12 is defined in the development and progression of different types of leukemia including acute myeloid leukemia,...

journal_title：European journal of pharmacology

authors： Zheng Y,Feng W,Wang YJ,Sun Y,Shi G,Yu Q

更新日期：2019-02-05 00:00:00

abstract：:The calcium currents (ICa) of isolated smooth muscle cells (urinary bladder of the guinea-pig) were analyzed at 35 degrees C and 3.6 mM [Ca]0. The whole cells were voltage-clamped with a single patch electrode which was filled with 150 mM CsCl in order to block potassium outward currents. Tiapamil reduced ICa at conce...

journal_title：European journal of pharmacology

authors： Klöckner U,Isenberg G

更新日期：1986-08-15 00:00:00

abstract：:Protons and capsaicin activate overlapping subsets of sensory nerves by opening ion conductances of similar properties. We have used the [3H]resiniferatoxin binding assay utilizing rat spinal cord membranes to elucidate the possible interaction of protons at the vanilloid (capsaicin) receptor. Using low pH (pH 6.0 and...

journal_title：European journal of pharmacology

authors： Szallasi A,Blumberg PM,Lundberg JM

更新日期：1995-04-28 00:00:00

abstract：:Human podocytes (hPC) are essential for maintaining normal kidney function and dysfunction or loss of hPC play a pivotal role in the manifestation and progression of chronic kidney diseases including diabetic nephropathy. Previously, α-Lipoic acid (α-LA), a licensed drug for treatment of diabetic neuropathy, was shown...

journal_title：European journal of pharmacology

authors： Leppert U,Gillespie A,Orphal M,Böhme K,Plum C,Nagorsen K,Berkholz J,Kreutz R,Eisenreich A

更新日期：2017-09-05 00:00:00

abstract：:The non N-methyl-D-aspartate (NMDA) receptor antagonists dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), both inhibit the visually driven response of sustained ganglion cells in the cat retina in vivo. In contrast to these findings, the potent NMDA receptor antagonist 3-[+/- )-2-ca...

journal_title：European journal of pharmacology

authors： Kay CD,Ikeda H

更新日期：1989-05-19 00:00:00

abstract：:Obese mice display overactive bladder (OAB) associated with impaired urethra smooth muscle (USM) function. In this study, we evaluated the role of the adipose tissue surrounding the urethra and prostate in obese mice (here referred as periprostatic adipose tissue; PPAT) to the USM dysfunction. Male C57BL6/JUnib mice f...

journal_title：European journal of pharmacology

authors： Alexandre EC,Calmasini FB,Sponton ACDS,de Oliveira MG,André DM,Silva FH,Delbin MA,Mónica FZ,Antunes E

更新日期：2018-10-05 00:00:00

abstract：:Induction of anaphylactic shock in mice by i.v. antigen challenge (bovine serum albumin, 100 micrograms) or i.v. treatment with the mast cell degranulator compound 48/80 resulted in 80 and 90% mortality rate, respectively. Inhibition of nitric oxide (NO) synthesis from L-arginine by co-injection of the L-arginine anal...

journal_title：European journal of pharmacology

authors： Amir S,English AM

更新日期：1991-10-02 00:00:00

abstract：:The positive chronotropic effect of angiotensin II was studied on the isolated spontaneously beating cat right atria. Angiotensin II and prostacyclin produced similar positive chronotropic and inotropic effects which were not affected by beta-adrenoceptor and histamine H2-receptor blockers. [Sar1,Ile8] angiotensin II,...

journal_title：European journal of pharmacology

authors： Türker RK

更新日期：1982-09-24 00:00:00

abstract：:Previous work from our laboratory has indicated that ovine prolactin can produce a rapid stimulation (within 1 h) of dopamine release from nigrostriatal and mesolimbic dopaminergic neurons of male rats. In the present experiment we attempted to determine whether this effect of prolactin was a function of an increase i...

journal_title：European journal of pharmacology

authors： Chen JC,Ramirez VD

更新日期：1989-08-03 00:00:00

abstract：:In cases of severe human scorpion envenoming, lung injury is a common finding and frequently the cause of death. In the rat, two distinct mechanisms account for oedema following the intravenous injection of the venom -- acute left ventricular failure resulting from a massive release of catecholamines and an increase i...

journal_title：European journal of pharmacology

authors： Matos IM,Souza DG,Seabra DG,Freire-Maia L,Teixeira MM

更新日期：1999-07-09 00:00:00

abstract：:In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats. Intracerebroventricular (i.c.v.) 0.5, 1.0 and 2.0 µmol CDP-choline and saline were administered to male Wistar-Albino rats. For the measurement of serum leptin and ghrelin levels, b...

journal_title：European journal of pharmacology

authors： Kiyici S,Basaran NF,Cavun S,Savci V

更新日期：2015-10-05 00:00:00