Acquired factor XI inhibitors in congenitally deficient patients.

abstract：:Newly identified iron binding proteins isolated from rat duodenal homogenates permit better understanding of iron absorption. Mucins bind iron at acid pH to keep iron soluble and available for absorption at the more alkaline pH of the duodenum; this explains iron deficiency following prolonged achlorhydria. Integrin (...

journal_title：American journal of hematology

authors： Conrad ME,Umbreit JN

更新日期：1993-01-01 00:00:00

abstract：:With the emerging success of treating CD19 expressing B cell malignancies with ex vivo modified, autologous T cells that express CD19-directed chimeric antigen receptors (CAR), there is intense interest in expanding this evolving technology to develop effective modalities to treat other malignancies including solid tu...

journal_title：American journal of hematology

authors： Perera LP,Zhang M,Nakagawa M,Petrus MN,Maeda M,Kadin ME,Waldmann TA,Perera PY

更新日期：2017-09-01 00:00:00

abstract：:In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not appear to be statist...

journal_title：American journal of hematology

authors： Nand S,Stock W,Godwin J,Fisher SG

更新日期：1996-05-01 00:00:00

abstract：:The roles of fibrinogen and fibronectin were contasted in the responses of human platelets to Staphylococcus aureus and collagen. Congenital afibrinogenemic (CA) platelets and washed normal platelets had delayed aggregation due to a prolonged latent phase in response to contact with the bacteria when fibrinogen was ab...

journal_title：American journal of hematology

authors： Clawson CC,White JG,Herzberg MC

更新日期：1980-01-01 00:00:00

abstract：:Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its ligand stem cell facto...

journal_title：American journal of hematology

authors： Pullarkat VA,Pullarkat ST,Calverley DC,Brynes RK

更新日期：2000-12-01 00:00:00

abstract：:Withdrawal: Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective. The above article, published online on 20 August 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article, has been withdrawn by agreement between the authors, t...

journal_title：American journal of hematology

authors： Cordeiro Mitchell CN,Pradhan A,Singh B,Naik RP,Baker VL,Lanzkron SM,Christianson MS,Pecker LH

更新日期：2020-08-20 00:00:00

abstract：:Neonatal alloimmune thrombocytopenia is an uncommon but important cause of thrombocytopenia in infants. Because of the severity of the thrombocytopenia, some of these infants will have intracranial hemorrhage with resultant long-term disability. Obstetricians and neonatologists have recommended delivery by caesarean s...

journal_title：American journal of hematology

authors： Burrows RF,Caco CC,Kelton JG

更新日期：1988-06-01 00:00:00

abstract：:We have studied telomere length in the bone marrow cells or the granulocyte and lymphocyte cell fractions of 54 patients with myelodysplastic syndromes (MDS) by Southern blot hybridization using the (TTAGGG)4 probe. The average telomere length expressed as the peak telomere repeat array (TRA) in the peripheral blood, ...

journal_title：American journal of hematology

authors： Boultwood J,Fidler C,Kusec R,Rack K,Elliott PJ,Atoyebi O,Chapman R,Oscier DG,Wainscoat JS

更新日期：1997-12-01 00:00:00

abstract：:Karyotypic analysis at time of diagnosis has an important value in determining initial response to treatment, remission duration and overall survival (OS) in acute myeloid leukemia (AML). Less is known about its value before allogeneic hematopoietic cell transplantation (allo-HCT) in patients transplanted with active ...

journal_title：American journal of hematology

authors： Poiani M,Labopin M,Battipaglia G,Beelen DW,Tischer J,Finke J,Brecht A,Forcade E,Ganser A,Passweg JR,Labussiere-Wallet H,Yakoub-Agha I,Schäfer-Eckart K,Kroeger N,Guffroy B,Ruggeri A,Esteve J,Nagler A,Mohty M

更新日期：2021-01-01 00:00:00

abstract：:Intensive induction chemotherapy using anthracycline and cytarabine backbone is considered the most effective upfront therapy in physically fit older patients with acute myeloid leukemia (AML). However, outcomes of the standard induction in elderly AML are inferior to those observed in younger patients, and they are s...

journal_title：American journal of hematology

authors： Pluta A,Robak T,Wrzesien-Kus A,Katarzyna Budziszewska B,Sulek K,Wawrzyniak E,Czemerska M,Zwolinska M,Golos A,Holowiecka-Goral A,Kyrcz-Krzemien S,Piszcz J,Kloczko J,Mordak-Domagala M,Lange A,Razny M,Madry K,Wiktor-Jedrze

更新日期：2017-04-01 00:00:00

abstract：:Autologous 51Cr-platelet kinetic studies were performed in splenectomized mongrel dogs. Mean survival time of PRP-platelets was 5.4 +/- 1.5 (SD) days (n = 6). The curves, though slightly curvilinear, showed mostly a linear type of decay, denoting that platelet removal from the circulation is mainly determined by aging...

journal_title：American journal of hematology

authors： Mezzano D,Aranda E,Foradori A,Rodríguez S,Lira P

更新日期：1984-01-01 00:00:00

abstract：:Because of the T-cell abnormalities observed in Hodgkin's disease and the growing number of Hodgkin's disease cases observed in association with the acquired immunodeficiency syndrome (AIDS), concern has been expressed that a retrovirus may be the primary cause of Hodgkin's disease. We examined plasma specimens from 1...

journal_title：American journal of hematology

authors： Chorba TL,Kalyanaraman VS,Lacher MJ,Schulof RS

更新日期：1988-01-01 00:00:00

abstract：:Hydroxyurea is a drug that is used to treat some patients with sickle cell disease. We have measured the deformability of sickle erythrocytes incubated in hydroxyurea in vitro and found that hydroxyurea acts to decrease the deformability of these cells. The deformability of normal erythrocytes was not significantly af...

journal_title：American journal of hematology

authors： Huang Z,Louderback JG,King SB,Ballas SK,Kim-Shapiro DB

更新日期：2001-07-01 00:00:00

abstract：:The goal of the present study was to search for criteria that allow one to distinguish between normal individuals and heterozygotes as well as compound heterozygotes for pyruvate kinase (PK) deficiency. As the residual activity of PK with heterozygotes was between 35% and 110% of the normal activity, it was necessary ...

journal_title：American journal of hematology

authors： Lakomek M,Winkler H,Linne S,Schröter W

更新日期：1989-08-01 00:00:00

abstract：:The effect of the synthetic vasopressin derivative 1-desamino-8D-arginine vasopressin (DDAVP = desmopressin) on bleeding time was studied in three patients with Hermansky Pudlak syndrome. A good response was observed in this type of storage pool disease. DDAVP might be useful in managing the bleeding disorder found in...

journal_title：American journal of hematology

authors： Wijermans PW,van Dorp DB

更新日期：1989-03-01 00:00:00

abstract：:Cerebrospinal fluid beta-2-microglobulin (CSF-beta 2m) was measured longitudinally in 48 patients affected by acute lymphoblastic leukemia (ALL). Thirteen developed a central nervous system (CNS) involvement during the course of the disease; although moderately higher mean CSF-beta 2m levels were found in these subjec...

journal_title：American journal of hematology

authors： Musto P,Tomasi P,Cascavilla N,Ladogana S,La Sala A,Melillo L,Nobile M,Castoldi G,Carotenuto M

更新日期：1988-08-01 00:00:00

abstract：:A 36-year-old white man was found to have low erythrocyte acetylcholinesterase activity. Plasma cholinesterase activity was normal. The propositus had mild anemia and moderate elliptocytosis, but was asymptomatic. A sister, brother, father, and nephew were hematologically normal, but had slightly subnormal red cell ac...

journal_title：American journal of hematology

authors： Shinohara K,Tanaka KR

更新日期：1979-01-01 00:00:00

abstract：:Heparin-associated thrombocytopenia with thrombosis (HATT) is fatal in 29% and leads to limb amputation in another 21% of patients. Patients with arterial thrombosis do worse than do those with venous thrombosis alone. Heparin-associated thrombocytopenia is mediated through IgG or IgM immunoglobulin fractions and is b...

journal_title：American journal of hematology

authors： Nand S,Robinson JA

更新日期：1988-07-01 00:00:00

abstract：:Patients initially diagnosed with type 1 von Willebrand disease (VWD) have been reclassified as type 2 after a more exhaustive analysis in several studies. Our study's objectives were (1) to reanalyze patients that were previously diagnosed as type 1 to achieve a more accurate diagnosis and (2) to compare the von Will...

journal_title：American journal of hematology

authors： Penas N,Pérez-Rodríguez A,Torea JH,Lourés E,Noya MS,López-Fernández MF,Batlle J

更新日期：2005-11-01 00:00:00

abstract：:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare form of Hodgkin lymphoma that typically presents as early stage, indolent disease in young adult males. The relationship between NLPHL and DLBCL is incompletely understood, and there remains a paucity of data with regard the incidence and management of ...

journal_title：American journal of hematology

authors： Eyre TA,Gatter K,Collins GP,Hall GW,Watson C,Hatton CS

更新日期：2015-06-01 00:00:00

abstract：:Antithymocyte globulins (ATG) plus cyclosporine (CSA) is the gold standard immunosuppressive treatment (IST) for patients with aplastic anemia. A prospective randomized trial showed in 2011 that hATG was superior to rabbit ATG for first-line treatment of severe AA. The French Health Agency (ANSM) permitted a patient-n...

journal_title：American journal of hematology

authors： Peffault de Latour R,Tabrizi R,Marcais A,Leblanc T,Lamy T,Mohty M,Tavitian S,Jubert C,Pasquet M,Galambrun C,Nguyen S,Cahn JY,Braun T,Deconinck E,Bay JO,Sicre de Fontbrune F,Barraco F,Socié G

更新日期：2018-05-01 00:00:00

abstract：:The value of menorrhagia as a predictor for mild bleeding disorders has been very little studied and the results are divergent. In the present study on 30 women with objectively verified menorrhagia, we found a significantly increased prevalence of von Willebrand's disease (20%). By keeping a strict sampling and labor...

journal_title：American journal of hematology

authors： Edlund M,Blombäck M,von Schoultz B,Andersson O

更新日期：1996-12-01 00:00:00

abstract：:Expression of alkaline phosphatase (ALP) on the surface membrane of neutrophils (mNAP) was studied by immunofluorescence using an anti-ALP monoclonal antibody. Fluorescent intensity distribution of mNAP was analyzed using FACS (fluorescence-activated cell sorter). The mean fluorescent intensity (MFI) of the mNAP in th...

journal_title：American journal of hematology

authors： Shibano M,Machii T,Nishimori Y,Nakamoto I,Ueda E,Masuhara K,Kitani T

更新日期：1999-01-01 00:00:00

abstract：:Flow cytometry (FCM) is an adjunct study to routine analysis of cerebrospinal fluid (CSF) to investigate for involvement by a hematologic malignancy. However, in our experience, FCM only infrequently detects abnormalities in CSF. To help optimize resources without forfeiting clinically important data, we sought to det...

journal_title：American journal of hematology

authors： Kovach AE,DeLelys ME,Kelliher AS,Dillon LJ,Hasserjian RP,Ferry JA,Preffer FI,Sohani AR

更新日期：2014-10-01 00:00:00

abstract：:Ten patients developing lymphomas after disease modifying anti-rheumatic drugs (DMARD) (methotrexate, n = 3, mean cumulative dose = 3.4 g; cyclophosphamide, n = 2, mean dose = 70 g; azathioprine, n = 6, mean dose = 243 g) were investigated. Methotrexate-related lymphomas were Epstein-Barr virus (EBV)-positive, had inf...

journal_title：American journal of hematology

authors： Au WY,Ma ES,Choy C,Chung LP,Fung TK,Liang R,Kwong YL

更新日期：2006-01-01 00:00:00

abstract：:Hb Saint Nazaire [beta 103 (G5) Phe-->Ile] was found in four apparently unrelated French families. The five patients carrying this hemoglobin have been detected because of a moderate erythrocytosis. The structural abnormality of Hb Saint Nazaire concerns the same residue as in Hb Heathrow [beta 103 (G5) Phe-->Leu). A ...

journal_title：American journal of hematology

authors： Wajcman H,Kister J,M'Rad A,Promé D,Milpied N,Rapp MJ,Harousseau JL,Riou J,Bardakdjian J,Galacteros F

更新日期：1993-09-01 00:00:00

abstract：:Specific anti-human thymus xenoantiserum (ATS) was utilized for characterizing a human thymus antigen (HTA) preferentially expressed on human thymocytes. Binding of ATS with different cell types was studied by immunofluorescence and immunoperoxidase techniques, as well as by radioimmunoprecipitation (RIP) followed by ...

journal_title：American journal of hematology

authors： Fujimoto J,Ishii Y,Koshiba H,Matsuura A,Ogasawara M,Uede T,Kikuchi K

更新日期：1981-01-01 00:00:00

abstract：:Although treatment with plasma exchange increased the survival of patients with thrombotic thrombocytopenia purpura to 80% in the 1980s, no further increase of survival occurred over the next 20 years. However, more consistent use of adjuvant treatment with corticosteroids and rituximab in recent years has begun to fu...

journal_title：American journal of hematology

authors： George JN

更新日期：2012-05-01 00:00:00

abstract：:High-density lipoprotein (HDL) of 100-400 micrograms/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1-5 microM). Highly concentrated HDL (1,200 micrograms/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist-induced p...

journal_title：American journal of hematology

authors： Pfennig O,Zhao B,Frye S,Dierichs R

更新日期：1995-12-01 00:00:00

abstract：:This paper describes, for the first time, the utilization of nebulized morphine in the management of severe chest pain in two young adult African-American patients who suffered from generalized acute sickle cell painful episodes. While hospitalized, both patients developed new sharp chest wall pain, and were treated w...

journal_title：American journal of hematology

authors： Ballas SK,Viscusi ER,Epstein KR

更新日期：2004-06-01 00:00:00