Effect of glucan on Leishmania major infection in BALB/c mice.

Abstract:

:The effect of glucan on Leishmania major infection was studied in BALB/c mice, which are highly susceptible to leishmania infection. Glucan (0.45 mg), or isovolumetric dextrose, was administered intraperitoneally 7, 5, 3 and 1 day before infection with L. major promastigotes. At 3, 5, 6, 8 and 10 weeks after infection, animals were killed; the liver and spleen of each animal were weighed and the parasite burden was calculated. A significant (p less than 0.01) reduction in amastigote proliferation in liver and spleen of animals pretreated with glucan was demonstrated 4, 6 and 8 weeks after infection.

journal_name

J Med Microbiol

authors

Al Tuwaijri AS,Mahmoud AA,Al Mofleh IA,Al Khuwaitir SA

doi

10.1099/00222615-23-4-363

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

363-5

issue

4

eissn

0022-2615

issn

1473-5644

journal_volume

23

pub_type

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