Lack of correlation between fecal blood loss and drug-induced gastric mucosal lesions.

Abstract:

:Increased fecal blood loss was produced in healthy volunteers by the administration of two nonsteroidal anti-inflammatory drugs (NSAID), naproxen or fenflumizole. Basal as well as drug-induced gastrointestinal blood loss was measured using 51Cr erythrocyte labeling. Median rise in daily fecal blood loss was 432%. All subjects were endoscoped at the initiation and at the completion of the study. Endoscopic findings were assessed quantitatively by two observers in two different ways. All subjects but three had gastric mucosal lesions at follow-up endoscopy. There was a good correlation between the endoscopic assessments but no statistical correlation between the endoscopic assessment and the increase in fecal blood loss. The data suggest that factors other than gastric mucosal lesions have to be taken into account when investigating NSAID-induced gastrointestinal bleeding.

journal_name

Gastrointest Endosc

authors

Hedenbro JL,Wetterberg P,Vallgren S,Bergqvist L

doi

10.1016/s0016-5107(88)71322-x

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

247-51

issue

3

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(88)71322-X

journal_volume

34

pub_type

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