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Pancreatic duct stent placement prevents post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction but normal manometry results.

Abstract：

BACKGROUND:Placement of a pancreatic duct (PD) stent reduces post-ERCP pancreatitis rates in high-risk patients. Patients with suspected sphincter of Oddi dysfunction (SOD) who are found to have normal manometry results (SOM) are also at high risk for this complication. OBJECTIVE:Our purpose was to determine whether PD stent placement reduces pancreatitis rates in this patient population. DESIGN:Non-randomized, retrospective study. SETTING:Large, tertiary referral center. PATIENTS:From January 1999 to December 2005, patients who underwent ERCP with normal SOM were identified from our ERCP database. Incidence of patient/procedure risk factors for post-ERCP pancreatitis, trainee participation, and prior sphincter therapy were evaluated. INTERVENTIONS:PD stent placement. MAIN OUTCOME MEASUREMENT:Pancreatitis rates. RESULTS:A total of 403 patients were available for analysis: 169 had a PD stent placed (group 1) and 234 did not (group 2). Overall, pancreatitis rates were 2.4% in group 1 and 9.0% in group 2 (P= .006, odds ratio 4.1, 95% CI 1.4-12.0). Other than increased PD opacification in group 1 (P< .001), the incidence of risk factors for pancreatitis, trainee participation, or prior sphincter therapy was similar between the 2 groups. In patients with an intact papilla, stent placement reduced the rate of pancreatitis from 11.5% to 2.7% (P= .012). In patients with prior sphincter therapy, no benefit was seen from stent placement, although there was a trend to decreased pancreatitis rates in stented patients with prior pancreatobiliary sphincterotomy. LIMITATIONS:Nonrandomized, retrospective design. CONCLUSION:Temporary PD stent placement reduces pancreatitis rates in patients with suspected SOD but normal SOM and an intact papilla. Their routine use is recommended when evaluating this difficult, high-risk patient population.

journal_name

Gastrointest Endosc

journal_title

Gastrointestinal endoscopy

authors

Saad AM,Fogel EL,McHenry L,Watkins JL,Sherman S,Lazzell-Pannell L,Lehman GA

doi

10.1016/j.gie.2007.06.022

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

255-61

issue

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(07)02147-5

journal_volume

pub_type

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Pancreatic duct stent placement prevents post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction but normal manometry results.