Long-term follow-up results of stepwise radical endoscopic resection for Barrett's esophagus with early neoplasia.


BACKGROUND AND AIMS:Stepwise radical endoscopic resection (SRER) has shown to be effective in eradicating Barrett's esophagus (BE) and its associated dysplasia. The aim of this study was to assess the long-term durability after successful SRER for early Barrett's neoplasia. METHODS:Patients treated with SRER for BE ≤5 cm with high-grade dysplasia (HGD) or early cancer (EC) and who had reached complete eradication of intestinal metaplasia (CE-IM) and neoplasia (CE-neo) were included. Primary outcomes were recurrence of neoplasia (HGD/EC), recurrence of dysplasia (indefinite for dysplasia included), and recurrence of endoscopically visible BE. Secondary outcomes were buried Barrett's glands, IM in biopsy specimens obtained distal to a normal-appearing neo-squamocolumnar junction (neo-SCJ), need for retreatment, and sustained CE-IM and CE-neo at the last follow-up endoscopy. RESULTS:Seventy-three patients were included (64 men; mean age, 66 years; median BE, C2M3). Median follow-up was 76 months. Recurrence of neoplasia was observed in 1 patient (T1bN0M0) after 129 months of follow-up and was treated with curative surgery (annual incidence of .22% per patient-year of follow-up). In 4 patients, recurrence of dysplasia was found (.87% per patient-year of follow-up). Twelve patients had recurrent endoscopically visible BE after a median follow-up of 22 months (2.6% per patient-year of follow-up), mostly small islands or tongues. Five patients had a single finding of buried Barrett's glands (1.1% per patient-year of follow-up), and 27 patients (5.9% per patient-year of follow-up) showed IM in biopsy specimens just distal to the neo-SCJ, which was not reproduced in 56%. Retreatment was performed in 9 patients. CE-IM and CE-neo (excluding IM in the neo-SCJ) at the last follow-up endoscopy was seen in 95% and 97% of patients, respectively. CONCLUSIONS:This study presents the longest published follow-up data on SRER to date. The 6-year outcomes show that successful SRER is a durable treatment for BE ≤5 cm with HGD/EC.


Gastrointest Endosc


Belghazi K,van Vilsteren FGI,Weusten BLAM,Meijer SL,Bergman JJGHM,Pouw RE




Has Abstract


2018-01-01 00:00:00














  • Evaluation of a new curved linear array echoendoscopy system for EUS.

    abstract:BACKGROUND:EUS-FNA can be used to accurately diagnose and stage GI and pulmonary neoplasms. This study evaluated the performance characteristics of a new compact linear EUS system during EUS-FNA. METHODS:A total of 37 patients enrolled in this prospective pilot study underwent clinically indicated EUS-FNA and/or celia...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Shamoun DK,Chak A,Levy MJ,Pfau P,Jondal ML,Wiersema MJ

    更新日期:2003-06-01 00:00:00

  • Catheter probe assisted endoluminal US in inflammatory bowel disease.

    abstract:BACKGROUND:Use of an echocolonoscope to examine patients with inflammatory bowel disease is technically difficult. Catheter probe assisted endoluminal ultrasonography (US) may be a feasible alternative. METHODS:Determination of demographic information and clinical disease activity was followed by colonoscopy with biop...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Soweid AM,Chak A,Katz JA,Sivak MV Jr

    更新日期:1999-07-01 00:00:00

  • EUS-guided portal pressure measurement using a digital pressure wire with real-time remote display: a novel, minimally invasive technique for direct measurement in an animal model.

    abstract:BACKGROUND AND AIMS:Hepatic venous pressure gradient (HVPG) currently serves as a surrogate for portal pressure measurement but has many limitations. We developed a novel technique for rapid and direct portal pressure measurements using a digital pressure wire delivered through an EUS-guided 22-gauge FNA needle. Our ai...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Schulman AR,Thompson CC,Ryou M

    更新日期:2016-04-01 00:00:00

  • Infrared video imaging of subsurface vessels: a feasibility study for the endoscopic management of gastrointestinal bleeding.

    abstract::The feasibility of infrared video imaging of subsurface vessels in the stomach was investigated both experimentally and in more detail using computer simulations of light propagation. Infrared video imaging was first attempted in several experimental situations. Images of a human arm illuminated with infrared light (w...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Gostout CJ,Jacques SL

    更新日期:1995-03-01 00:00:00

  • Clinical relevance of endoscopic treatment for superficial pharyngeal cancer: feasibility of techniques corresponding to each location and long-term outcomes.

    abstract:BACKGROUND AND AIMS:Superficial pharyngeal cancers are being detected and treated using endoscopy in many medical facilities with increasing frequency. However, the reports focus on the hypopharynx. We identified reliable treatments by adapting the method for each region of the pharynx. Here, we introduce our methods f...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Iizuka T,Kikuchi D,Suzuki Y,Tanaka M,Takeda H

    更新日期:2020-07-25 00:00:00

  • Three-dimensional esophageal varix model quantification of variceal volume by high-resolution endoluminal US.

    abstract:BACKGROUND:The purpose of this study was to evaluate the accuracy and reproducibility of three-dimensional volume measurements by high-resolution endoluminal ultrasound in an esophageal varix model. METHODS:An esophageal varix model was made by filling three esophageal dilatation catheters with various volumes of wate...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Chung CY,McCray WH,Dhaliwal S,Haywood T,Black M,Liu JB,Miller LS

    更新日期:2000-07-01 00:00:00

  • Methylene blue staining for intestinal metaplasia of the gastric cardia with follow-up for dysplasia.

    abstract:BACKGROUND:Previous studies by our group have identified a 23% prevalence of intestinal metaplasia involving the gastric cardia in patients undergoing elective esophagogastroduodenoscopy (EGD). The current study evaluates the potential clinical utility of vital staining with methylene blue for detecting intestinal meta...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Morales TG,Bhattacharyya A,Camargo E,Johnson C,Sampliner RE

    更新日期:1998-07-01 00:00:00

  • Electrocautery therapy for refractory anastomotic strictures of the esophagus.

    abstract:BACKGROUND:Anastomotic esophageal stenoses after esophageal resection are common and sometimes are refractory to Savary bougie dilation. The efficacy of electrocautery needle-knife treatment in these patients is described. METHODS:Twenty patients with a refractory anastomotic stricture of the esophagus were treated wi...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Hordijk ML,Siersema PD,Tilanus HW,Kuipers EJ

    更新日期:2006-01-01 00:00:00

  • Witzel pneumatic dilation for achalasia: safety and long-term efficacy.

    abstract::Forceful dilation of the lower esophageal sphincter is considered primary therapy for achalasia. The Witzel pneumatic balloon dilator, unlike fluoroscopically placed dilators, is placed over a standard gastroscope allowing positioning and dilation under direct vision. We report our experience with the Witzel dilator i...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Barnett JL,Eisenman R,Nostrant TT,Elta GH

    更新日期:1990-09-01 00:00:00

  • Colonic endoscopic full-thickness biopsies: from the neuropathological analysis of the myenteric plexus to the functional study of neuromuscular transmission.

    abstract:BACKGROUND:Better understanding of the pathophysiological mechanisms involved in severe dysmotility disorders is crucial to improve patient management and identify novel therapeutic targets. Recent studies suggested that endoscopic full-thickness biopsies (eFTBs) could be developed as an alternative to surgical biopsie...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Neunlist M,Coquenlorge S,Aubert P,Duchalais-Dassonneville E,des Varannes SB,Meurette G,Coron E

    更新日期:2011-05-01 00:00:00

  • Endoscopy and EUS are key for effective surveillance and management of duodenal adenomas in familial adenomatous polyposis.

    abstract:BACKGROUND:Patients with familial adenomatous polyposis (FAP) are prone to developing duodenal adenoma and cancer. Optimal surveillance and management of these adenomas are not well established. OBJECTIVE:We assessed the outcome of FAP patients undergoing intense multimodal surveillance and subsequent endoscopic resec...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Gluck N,Strul H,Rozner G,Leshno M,Santo E

    更新日期:2015-04-01 00:00:00

  • Does the addition of methylene blue to the sclerosant improve the accuracy of injections during variceal sclerotherapy?

    abstract::We evaluated the possibility that the addition of methylene blue to the sclerosant would improve the accuracy of intravariceal injections during endoscopic variceal sclerotherapy. Four patients had eight sessions of endoscopic variceal sclerotherapy with a sclerosant containing a combination of 3% sodium tetradecyl an...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Waring JP,Sanowski RA,Pardy K,Talbert G,Chinichian A

    更新日期:1991-03-01 00:00:00

  • Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.

    abstract:BACKGROUND AND AIMS:The role of electroacupuncture (EA) in reducing sedative and analgesic requirements during EUS is uncertain. The aim of this study was to investigate the efficacy of EA in reducing procedure-related pain and discomfort during EUS. METHODS:This was a double-blinded randomized controlled study conduc...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,随机对照试验


    authors: Teoh AYB,Chong CCN,Leung WW,Chan SKC,Tse YK,Ng EKW,Lai PBS,Wu JCY,Lau JYW

    更新日期:2018-02-01 00:00:00

  • A prospective multicenter study using a new multiband mucosectomy device for endoscopic resection of early neoplasia in Barrett's esophagus.

    abstract:BACKGROUND AND AIMS:Early neoplasia in Barrett's esophagus (BE) can be effectively and safely removed by endoscopic resection (ER) using multiband mucosectomy (MBM). This study aimed to document performance of a novel MBM device designed for improved visualization, easier passage of accessories, and better suction powe...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,多中心研究


    authors: Pouw RE,Beyna T,Belghazi K,Koch AD,Schoon EJ,Haidry R,Weusten BL,Bisschops R,Shaheen NJ,Wallace MB,Marcon N,Heise-Ginsburg R,Gotink AW,Wang KK,Leggett CL,Ortiz-Fernández-Sordo J,Ragunath K,DiPietro M,Pech O,Neuhaus

    更新日期:2018-10-01 00:00:00

  • Double balloon endoscopy for pancreatic and biliary access in altered anatomy (with videos).

    abstract:BACKGROUND:Access to the papilla of Vater or enteral anastomoses to the biliary tract or pancreatic duct is difficult in patients with altered anatomy. The usual approach to the papilla of Vater with a side-viewing duodenoscope, designed for passage through the stomach, pyloric channel, and proximal duodenum, is not su...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Haber GB

    更新日期:2007-09-01 00:00:00

  • Laparoscopic-assisted double-balloon enteroscopy for small-bowel polyp surveillance and treatment in patients with Peutz-Jeghers syndrome.

    abstract:BACKGROUND:Surveillance and treatment of small-bowel polyps in patients with Peutz-Jeghers syndrome (PJS) can be challenging and may require intraoperative enteroscopy. While initial reports that used double-balloon enteroscopy (DBE) for the resection of small-bowel polyps in patients with PJS appear promising, complet...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Ross AS,Dye C,Prachand VN

    更新日期:2006-12-01 00:00:00

  • Long-term outcome in patients with benign biliary strictures treated endoscopically with multiple stents.

    abstract:BACKGROUND:The long-term efficacy of sequential insertion of multiple plastic stents for benign biliary strictures is poorly defined. The aims of this study were to evaluate the long-term outcome (bile duct patency, complications) of this therapy and to identify predictors of a good outcome. METHODS:Retrospective revi...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Draganov P,Hoffman B,Marsh W,Cotton P,Cunningham J

    更新日期:2002-05-01 00:00:00

  • An improved technique for accessory papilla cannulation in pancreas divisum.

    abstract::Cannulation of the accessory papilla with dorsal pancreas ductography was accomplished in 13 of 15 consecutive cases of pancreas divisum. When routine cannulation of the main pancreatic papilla fails to produce a pancreatogram or yields only a ventral pancreas, the use of intravenous secretin and a 23-gauge needle cat...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: O'Connor KW,Lehman GA

    更新日期:1985-02-01 00:00:00

  • Prospective analysis of complications 30 days after outpatient colonoscopy.

    abstract:BACKGROUND:Our objective was to (1) determine whether more complications are reported by patients 30 days after outpatient colonoscopy than are discussed at our monthly morbidity and mortality conferences, (2) identify complications resulting in visits to the emergency department or physician's office or leading to hos...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Zubarik R,Fleischer DE,Mastropietro C,Lopez J,Carroll J,Benjamin S,Eisen G

    更新日期:1999-09-01 00:00:00

  • Prevalence of adenomas and advanced adenomas in patients in the 40- to 49-year age group undergoing screening colonoscopy because of a family history of adenoma/polyp in a first-degree relative.

    abstract:BACKGROUND:Per current guidelines, patients with a first-degree relative (FDR) with adenomas should get screened at age 40. Data on the prevalence of adenomas and advanced adenomas (AAs) in these patients are lacking. OBJECTIVE:To examine the prevalence of adenomas and AAs in 40- to 49-year-old individuals undergoing ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Gupta A,Samadder J,Elliott E,Sethi S,Schoenfeld P

    更新日期:2012-04-01 00:00:00

  • EUS-derived criteria for distinguishing benign from malignant metastatic solid hepatic masses.

    abstract:BACKGROUND:Detection of hepatic metastases during EUS is an important component of tumor staging. OBJECTIVE:To describe our experience with EUS-guided FNA (EUS-FNA) of solid hepatic masses and derive and validate criteria to help distinguish between benign and malignant hepatic masses. DESIGN:Retrospective study, sur...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Fujii-Lau LL,Abu Dayyeh BK,Bruno MJ,Chang KJ,DeWitt JM,Fockens P,Forcione D,Napoleon B,Palazzo L,Topazian MD,Wiersema MJ,Chak A,Clain JE,Faigel DO,Gleeson FC,Hawes R,Iyer PG,Rajan E,Stevens T,Wallace MB,Wang KK,

    更新日期:2015-05-01 00:00:00

  • Endoscopic features of celiac disease in children.

    abstract:BACKGROUND:Endoscopic abnormalities have been described in adult patients with celiac disease that may suggest the diagnosis, especially when the presentation is atypical. METHODS:The duodenum of 140 children undergoing EGD for various different indications was evaluated macroscopically and histologically. RESULTS:Hi...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Ravelli AM,Tobanelli P,Minelli L,Villanacci V,Cestari R

    更新日期:2001-12-01 00:00:00

  • Gastric acid secretion, parietal cell sensitivity, and endoscopic characteristics of duodenal ulcer patients with and without stigmata of recent bleeding.

    abstract::Duodenal ulcer patients with stigmata of recent hemorrhage are at high risk of rebleeding. Whether the acid secretory capacity, the parietal cell sensitivity and endoscopic characteristics are different in patients with and without stigmata of recent hemorrhage are unclear. To investigate these, we studied 885 patient...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Hui WM,Lam SK

    更新日期:1992-05-01 00:00:00

  • Endoscopic mucosal resection with full-thickness closure for difficult polyps: a prospective clinical trial.

    abstract:BACKGROUND:Large flat polyps may be more amenable to endoscopic resection if an endoluminal method for full-thickness closure were available. OBJECTIVE:Assessment of feasibility of endoluminal full-thickness closure. DESIGN:Prospective, open-label, interventional study. SETTING:Tertiary referral center. PATIENTS:Pa...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章


    authors: Agrawal D,Chak A,Champagne BJ,Marks JM,Delaney CP

    更新日期:2010-05-01 00:00:00

  • Prediction of bleeding and stricture formation after corrosive ingestion by EUS concurrent with upper endoscopy.

    abstract:BACKGROUND:Upper endoscopy provides information that can be used to predict complications and to facilitate clinical decisions for patients who have ingested corrosive substances. The role of EUS in corrosive injury has not been investigated. The aim of this study was to determine whether concurrent catheter-probe EUS ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Chiu HM,Lin JT,Huang SP,Chen CH,Yang CS,Wang HP

    更新日期:2004-11-01 00:00:00

  • Short-term outcomes of double versus single pyloromyotomy at peroral endoscopic pyloromyotomy in the treatment of gastroparesis (with video).

    abstract:BACKGROUND AND AIMS:The prevalence of gastroparesis (Gp), a chronic debilitating disorder, and resulting hospitalizations are increasing. Gastric peroral endoscopic pyloromyotomy (POP or GPOEM) is a novel technique in the treatment of refractory Gp. Despite the initial promising results of GPOEM, one-third of patients ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Abdelfatah MM,Li B,Kapil N,Noll A,Li L,Luo H,Chen H,Xia L,Chen X,Patel V,Mekaroonkamol P,Massaad J,Keilin S,Cai Q

    更新日期:2020-09-01 00:00:00

  • Palliation of patients with dysphagia due to advanced esophageal cancer by endoscopic injection of cisplatin/epinephrine injectable gel.

    abstract:BACKGROUND:The aim of therapy for advanced esophageal cancer is relief of dysphagia with minimal treatment-related morbidity. This study assessed the efficacy of endoscopic intratumoral injection of cisplatin/epinephrine gel to relieve obstruction and improve swallowing. The gel is designed to minimize diffusion of act...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Harbord M,Dawes RF,Barr H,Giovannini M,Viens P,Eysselein V,Mishra L,Orenberg EK,Bown SG

    更新日期:2002-11-01 00:00:00

  • Large-caliber metal stents versus plastic stents for the management of pancreatic walled-off necrosis.

    abstract:BACKGROUND AND AIMS:Symptomatic pancreatic walled-off necrosis (WON) may be managed by endoscopic transmural drainage and endoscopic transmural necrosectomy, with stent placement at endoscopic drainage sites. The optimal stent choice is yet to be determined. We compared outcomes after endoscopic management of WON using...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Abu Dayyeh BK,Mukewar S,Majumder S,Zaghlol R,Vargas Valls EJ,Bazerbachi F,Levy MJ,Baron TH,Gostout CJ,Petersen BT,Martin J,Gleeson FC,Pearson RK,Chari ST,Vege SS,Topazian MD

    更新日期:2018-01-01 00:00:00

  • A comparison of magnifying and nonmagnifying colonoscopy for diagnosis of colorectal polyps: A prospective study.

    abstract:BACKGROUND:Discrimination between neoplastic and non-neoplastic colorectal polyps is essential for determining appropriate treatment. The mucosal crypt pattern of polyps can be observed with a nonmagnifying colonoscope; however, mucosal crypt patterns are better seen by magnifying colonoscopy, which can also be a nonin...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Konishi K,Kaneko K,Kurahashi T,Yamamoto T,Kushima M,Kanda A,Tajiri H,Mitamura K

    更新日期:2003-01-01 00:00:00

  • Characteristics of magnified endoscopic images of gastric extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue, including changes after treatment.

    abstract:BACKGROUND:The utility of magnifying endoscopy for diagnosis of epithelial tumors has been reported, but there are few reports for nonepithelial tumors. OBJECTIVE:To determine the characteristics of magnified images of gastric extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymp...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Ono S,Kato M,Ono Y,Itoh T,Kubota K,Nakagawa M,Shimizu Y,Asaka M

    更新日期:2008-10-01 00:00:00