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Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A.

Abstract：

:The three-dimensional structure of the membrane glycoprotein neuraminidase of an escape mutant of the influenza virus strain A/Tokyo/3/67 has been determined to 3 A (1 A = 0.1 nm) resolution by X-ray diffraction. The mutant virus, selected by growing the virus in the presence of a monoclonal antibody to the neuraminidase, is shown to have undergone a single amino acid change of lysine to glutamic acid at residue 368. The three-dimensional structure of the neuraminidase is identical with that reported for A/Tokyo/3/67, except for a purely local adjustment of the structure at position 368.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Varghese JN,Webster RG,Laver WG,Colman PM

doi

10.1016/0022-2836(88)90344-0

subject

Has Abstract

pub_date

1988-03-05 00:00:00

pages

201-3

issue

1

eissn

0022-2836

issn

1089-8638

pii

0022-2836(88)90344-0

journal_volume

200

pub_type

杂志文章

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