Abstract:
:Twenty-one patients with recurrent malignant central nervous system gliomas were treated with a combination of 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. Thirteen patients had brain stem gliomas, 3 patients had spinal cord gliomas, 3 patients had thalamic gliomas, and 2 patients had cerebellar astrocytomas. All patients had received radiation therapy, and 4 brain stem patients had also been treated with chemotherapy. Sixteen patients (76%) responded to treatment with either stabilization of disease or improvement. Nine of the 13 patients with brain stem gliomas (71%) had response or stabilization of disease. The median time to tumor progression (TTP) for the brain stem patients who responded or had stabilization of disease was 25 weeks. The median survival from recurrence for the brain stem glioma patients was 27 weeks. Patients with cerebellar, thalamic, and spinal cord tumors did very well, with an 87% response or stabilization of disease and a median TTP of 122 weeks.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Rodriguez LA,Prados M,Fulton D,Edwards MS,Silver P,Levin Vdoi
10.1227/00006123-198804000-00012subject
Has Abstractpub_date
1988-04-01 00:00:00pages
691-3issue
4eissn
0148-396Xissn
1524-4040journal_volume
22pub_type
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