Intravenous Tissue Plasminogen Activator for Large Vessel Ischemic Stroke - Is There Still a Role?

abstract：BACKGROUND:Pernkopf's atlas of Anatomy contains anatomical plates with detailed images of the peripheral nerves. Its use is controversial due to the author's association with the "Third Reich" and the potential depiction of victims of the Holocaust. The ethical implications of using this atlas for informing surgical pl...

journal_title：Neurosurgery

authors： Yee A,Coombs DM,Hildebrandt S,Seidelman WE,Coert JH,Mackinnon SE

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Animal models and clinical studies suggest that intraventricular thrombolysis improves clot resolution and clinical outcomes among patients with intraventricular hemorrhage. However, this intervention may increase the rates of rebleeding and infection. To assess the safety and efficacy of intraventricular thr...

journal_title：Neurosurgery

authors： Naff NJ,Hanley DF,Keyl PM,Tuhrim S,Kraut M,Bederson J,Bullock R,Mayer SA,Schmutzhard E

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The cervical total disc replacement (cTDR) was developed to treat cervical degenerative disc disease while preserving motion. OBJECTIVE:Cost-effectiveness of this intervention was established by looking at 2-year follow-up, and this update reevaluates our analysis over 5 years. METHODS:Data were derived fr...

journal_title：Neurosurgery

authors： Ament JD,Yang Z,Nunley P,Stone MB,Lee D,Kim KD

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Although favorable clinical outcomes have been reported for instrumented lumbar interbody fusion (LIF), adjacent segment degeneration (ASD) has been reported as a long-term complication after LIF. OBJECTIVE:To investigate ASD after instrumented LIF performed at a single level and only for the homogeneous di...

journal_title：Neurosurgery

authors： Bae JS,Lee SH,Kim JS,Jung B,Choi G

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Although it is thought to be a safe treatment option, the main concerns related to treating vertebral artery ostium (VAO) stenosis with stents have been the rate of restenosis and the uncertain long-term results. OBJECTIVE:To evaluate the angiographic and clinical results of stent placement for atherosclero...

journal_title：Neurosurgery

authors： Hatano T,Tsukahara T,Miyakoshi A,Arai D,Yamaguchi S,Murakami M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:There has not been any effective prophylaxis for delayed cerebral ischemia delayed cerebral ischemia (DCI) since the introduction of nimodipine. Platelet inhibition may reduce the risk by preventing the formation of microthrombi. Tirofiban has been used as a single monotherapy bridge given its safety profile...

journal_title：Neurosurgery

authors： Zanaty M,Osorno-Cruz C,Byer S,Roa JA,Limaye K,Ishii D,Nakagawa D,Torner J,Yongjun L,Ortega-Gutiérrez S,Samaniego EA,Allan L,Hasan D

更新日期：2020-10-15 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether embryonic central nervous system transplants assisted cut dorsal root axons of adult rats to regenerate into the spinal cord. METHODS:Rats received transplants of embryonic spinal cord, hippocampus, or neocortex into dorsal quadrant cavities aspirated in the lum...

journal_title：Neurosurgery

authors： Itoh Y,Mizoi K,Tessler A

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:The increasing number of neurosurgical procedures for elderly patients and the development of skull base neurosurgery have increased interest in cerebral venous injury that might occur in a neurosurgical setting. Brain-derived neurotrophic factor (BDNF) may have neuroprotective effects against cerebral venou...

journal_title：Neurosurgery

authors： Takeshima Y,Nakamura M,Miyake H,Tamaki R,Inui T,Horiuchi K,Wajima D,Nakase H

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Recent studies of age-related effects on cognition and performance have raised concerns about the appropriate timing and regulatory surveillance of retirement for surgeons. Little is known about the practice patterns and retirement plans of aging neurosurgeons. Analyses of informed opinions on possible regula...

journal_title：Neurosurgery

authors： Scarrow AM,Linskey M,Asher AL,Anderson VC,Selden NR

更新日期：2009-08-01 00:00:00

abstract：:The object of this study was to determine whether the addition of information on brain stem reflexes improves the prognostic precision of the Glasgow coma scale for patients with severe head trauma. The study is based on 109 patients with a Glasgow coma score of 7 or less during the first 24 hours after injury. The av...

journal_title：Neurosurgery

authors： Born JD,Albert A,Hans P,Bonnal J

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:Many patients with symptomatic Chiari I malformations experience symptom recurrence after surgical decompression. Identification of predictors of outcome is needed to better select patients most likely to benefit from surgical intervention. We examined whether or not cerebrospinal fluid (CSF) flow dynamics as...

journal_title：Neurosurgery

authors： McGirt MJ,Nimjee SM,Fuchs HE,George TM

更新日期：2006-07-01 00:00:00

abstract：:These experiments were done to develop techniques to expose and manipulate the spinal cord in fetal rats, techniques that could be used to study spinal cord regeneration and transplantation. Adequate maternal anesthesia required a mixture of acepromazine-ketamine supplemented by thiopental. Fetal rats were operated on...

journal_title：Neurosurgery

authors： Albright L

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:The biggest downside of cerebral aneurysm coiling is the high rates of recurrence and retreatments. With the increasing number of aneurysm recurrences after failed coiling procedures, the best retreatment strategy remains unknown. OBJECTIVE:To assess the efficacy and safety of the Pipeline Embolization Devi...

journal_title：Neurosurgery

authors： Daou B,Starke RM,Chalouhi N,Tjoumakaris S,Khoury J,Hasan D,Rosenwasser RH,Jabbour PM

更新日期：2015-11-01 00:00:00

abstract：:Although multiple cerebral aneurysms ae well recognized, a new aneurysm has only rarely been documented after successful treatment for an aneurysm elsewhere. In our consecutive series of 986 patients with intracranial saccular arterial aneurysm collected from 1975 to 1990, nine patients who had previously unverified (...

journal_title：Neurosurgery

authors： Sakaki T,Tominaga M,Miyamoto K,Tsunoda S,Hiasa Y

更新日期：1993-04-01 00:00:00

abstract：:The Harvard Neurosurgical Service at Brigham and Women's Hospital and Children's Hospital Boston has a distinguished history, beginning in 1912 when Dr. Harvey Cushing became surgeon-in-chief at the Peter Bent Brigham Hospital. After Cushing left in 1932, the Children's Hospital had a dominant role, with the creation ...

journal_title：Neurosurgery

authors： Shillito J,Black PM

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Hemifacial spasm caused by a cerebellopontine angle lipoma is extremely rare. We describe a patient with left-sided hemifacial spasm caused by vascular compression of the facial and vestibulocochlear cranial nerves by the anteroinferior cerebellar artery embedded within a cerebellopontine angle lipoma. CLINI...

journal_title：Neurosurgery

authors： Barajas RF Jr,Chi J,Guo L,Barbaro N

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Interstitial infusion, a form of local delivery that bypasses the blood-brain barrier, has been shown to afford high regional concentrations of a therapeutic molecule while avoiding systemic exposure. The distribution of monoclonal antibodies administered via interstitial infusion has not been characterized, ...

journal_title：Neurosurgery

authors： Luther N,Cheung NK,Dunkel IJ,Fraser JF,Edgar MA,Gutin PH,Souweidane MM

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To further elucidate the importance of anatomic variations in morphology of the foramen magnum and associated clinical implications, we conducted a morphometric study. METHODS:Seventy-two dry skulls were used for this study. Digital images were obtained of the foramen magnum from an inferior view. These imag...

journal_title：Neurosurgery

authors： Tubbs RS,Griessenauer CJ,Loukas M,Shoja MM,Cohen-Gadol AA

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) is a potent angiogenic growth factor implicated in the tumor angiogenesis/metastasis of a number of human cancers. Activation of receptors for VEGF/VPF is specifically mitogenic to endothelial cells and increases their permeability. ...

journal_title：Neurosurgery

authors： Provias J,Claffey K,delAguila L,Lau N,Feldkamp M,Guha A

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:Frequently, the cervicothoracic junction can be reached through a simple anterior approach. In some cases, access to this region requires a much more aggressive surgical intervention, such as manubriotomy or sternotomy. Information regarding the need for such interventions is particularly useful to have preop...

journal_title：Neurosurgery

authors： Karikari IO,Powers CJ,Isaacs RE

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:We report the design and initial characterization of the dosimetry and radiobiology of a novel device for interstitial stereotactic radiosurgery. INSTRUMENTATION:The device is lightweight, handheld, and battery-powered, and it emits x-ray radiation from the tip of a probe 3 mm in diameter by 10 cm in length....

journal_title：Neurosurgery

authors： Hakim R,Zervas NT,Hakim F,Butler WE,Beatty J,Yanch JC,Biggs PJ,Gall KP,Sliski AP

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Cervical spinal cord stimulation (SCS) augments cerebral blood flow (CBF) in a number of animal models. The mechanisms underlying the cerebrovascular effects of SCS are not yet well delineated. In this study, we analyzed two alternative pathways in CBF alterations induced by SCS in rats, one involving direct ...

journal_title：Neurosurgery

authors： Patel S,Huang DL,Sagher O

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Intracerebral hemorrhage occurring after removal of a chronic subdural hematoma (CSH) is a rare but usually devastating postoperative complication. In patients with CSH, we determined cerebral blood flow immediately after surgical decompression to clarify the pathogenic mechanism of this complication. METHOD...

journal_title：Neurosurgery

authors： Ogasawara K,Koshu K,Yoshimoto T,Ogawa A

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The role of chemotherapy in the treatment of low-grade oligodendrogliomas and oligoastrocytomas is still unclear. A Phase II study was conducted to determine the benefits and toxicity of the procarbazine, lomustine, and vincristine (PCV) regimen in patients with low-grade oligodendrogliomas and oligoastrocyto...

journal_title：Neurosurgery

authors： Soffietti R,Rudà R,Bradac GB,Schiffer D

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:We describe an alternative surgical technique for treatment of Chiari I malformation associated with ventral compression and instability of the region. An expansive suboccipital cranioplasty and a rigid occipitocervical fixation are performed in one stage. METHODS:The occipitocervical fixation...

journal_title：Neurosurgery

authors： Nishikawa M,Ohata K,Baba M,Terakawa Y,Hara M

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The Centers for Disease Control and Prevention have called for studies detailing the prevalence and burden of mild traumatic brain injury (mTBI) in the outpatient clinical setting. OBJECTIVE:The aim of this study was to describe the prevalence of outpatient visits for minor head injury and compare the numbe...

journal_title：Neurosurgery

authors： Mannix R,O'Brien MJ,Meehan WP 3rd

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration. OBJECTIVE:To determine if fluorescence represents a prognostic marker in LGG. METHODS:Seventy-four consecutive patients with LGG (World Health Organiza...

journal_title：Neurosurgery

authors： Jaber M,Ewelt C,Wölfer J,Brokinkel B,Thomas C,Hasselblatt M,Grauer O,Stummer W

更新日期：2019-06-01 00:00:00

abstract：:Fourteen patients with acoustic neurinomas varying in size from 7 to 30 mm were treated by stereotactic radiosurgery and then were followed for 4 years. The tumors of eight patients decreased 1 to 10 mm in diameter, no change was found in two, and the tumor increased slightly in three patients. Loss of the ability to ...

journal_title：Neurosurgery

authors： Norén G,Arndt J,Hindmarsh T

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:Y-stent-assisted coiling is one of the eligible techniques for the treatment of complex bifurcation aneurysms. In majority of previous literature, Y-stenting has been performed using stents that could be delivered through large profile microcatheters that are often difficult to manipulate during navigation t...

journal_title：Neurosurgery

authors： Aydin K,Balci S,Sencer S,Barburoglu M,Umutlu MR,Arat A

更新日期：2020-09-15 00:00:00

abstract：:The concept of spinal cord injury has existed since the earliest human civilizations, with the earliest documented cases dating back to 3000 BC under the Egyptian Empire. Howevr, an understanding of this field developed slowly, with real advancements not emerging until the 20th century. Technological advancements incl...

journal_title：Neurosurgery

authors： Thakur JD,Wild E,Menger R,Hefner M,Adeeb N,Kalakoti P,Nanda A

更新日期：2020-06-01 00:00:00