Combined intra-arterial and systemic chemotherapy for recurrent malignant brain tumors.

Abstract:

:Seventy-nine patients harboring recurrent brain tumors received four cycles of infraophthalmic carotid injections of 160 mg of carmustine. Two milligrams of intravenous vincristine and 50 mg of oral procarbazine was also administered three times daily for 1 week in conjunction with each BCNU treatment. The response rate was 60% with a median survival for patients with astrocytomas, anaplastic astrocytomas, and glioblastomas of 32, 20, and 6.5 months, respectively. The median survival of the responding patients was 20 months, and the survival at 30 months was 45%. The survival in patients not responding to treatment was 5 months, reflecting the natural history of the tumor. There have been no deaths related to the treatment procedure. No incidents of severe or permanent eye complications or leukoencephalopathy were observed. Based on multivariate survival analysis, only patients with a good performance status who are not steroid dependent are candidates for this treatment.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Watne K,Hannisdal E,Nome O,Hager B,Hirschberg H

doi

10.1227/00006123-199202000-00012

keywords:

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

223-7

issue

2

eissn

0148-396X

issn

1524-4040

journal_volume

30

pub_type

临床试验,杂志文章
  • Primary malignant tumors of the sphenoidal sinus.

    abstract:OBJECTIVE:Neoplasms of the paranasal sinuses account for 0.2 to 0.8% of all cancers and for 2 to 3% of head and neck cancers. Primary involvement of the sphenoidal sinus has been reported to occur in only 1 to 2% of all paranasal sinus tumors. Tumors at this site commonly present with cranial neuropathies and require m...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200005000-00012

    authors: DeMonte F,Ginsberg LE,Clayman GL

    更新日期:2000-05-01 00:00:00

  • Stereotactic Radiosurgery for Arteriovenous Malformations: The Effect of Treatment Period on Patient Outcomes.

    abstract:BACKGROUND:Stereotactic radiosurgery (SRS) has been performed on patients with cerebral arteriovenous malformations (AVMs) for over 40 years. OBJECTIVE:To evaluate the impact of treatment period on obliteration, intracranial hemorrhage (ICH), and radiation-induced complications (RICs). METHODS:Retrospective compariso...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000001085

    authors: Pollock BE,Link MJ,Stafford SL,Garces YI,Foote RL

    更新日期:2016-04-01 00:00:00

  • Anatomoradiological landmarks for accuracy of radiofrequency thermorhizotomy in the treatment of trigeminal neuralgia.

    abstract:OBJECTIVE:The correct positioning of the electrode is of prime importance for effectiveness and selectivity of percutaneous trigeminal radiofrequency thermorhizotomy (RF-TR) for the treatment of trigeminal neuralgia (TN). The aim of our study was to establish some anatomoradiological landmarks for the purpose of accura...

    journal_title:Neurosurgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1227/01.neu.0000335027.00650.83

    authors: Tatli M,Sindou M

    更新日期:2008-07-01 00:00:00

  • An anthropomorphic phantom study of the accuracy of Cyberknife spinal radiosurgery.

    abstract:OBJECTIVE:Stereotactic radiosurgery requires the highest degree of accuracy in target identification and localization. When targeting paraspinal lesions, the CyberKnife radiosurgical system (Accuray, Inc., Sunnyvale, CA) uses implanted stainless steel fiducials. The purpose of this study was to evaluate the total syste...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000141080.54647.11

    authors: Yu C,Main W,Taylor D,Kuduvalli G,Apuzzo ML,Adler JR Jr

    更新日期:2004-11-01 00:00:00

  • Impairment of motor recovery after late nerve suture: experimental study in the rabbit. Part 1: functional and electromyographic findings.

    abstract::To study the motor recovery after increasingly late nerve suture, we severed 75 rabbit peroneal nerves and reanastomosed them by microsurgical epineural technique after a delay of up to 12 months. Functional, electromyographic, and morphological parameters were used to evaluate the quality of motor function 6 months a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Richter HP

    更新日期:1982-01-01 00:00:00

  • Long-term follow-up of blister aneurysms of the internal carotid artery.

    abstract:BACKGROUND:Blister aneurysms of the internal carotid artery (ICA) are uncommon. There is a paucity of data on the long-term outcomes of patients. OBJECTIVE:To review our experience with the treatment of these lesions. METHODS:We retrospectively reviewed all aneurysms treated at our institution between 1994 and 2005. ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000147

    authors: Kalani MY,Zabramski JM,Kim LJ,Chowdhry SA,Mendes GA,Nakaji P,McDougall CG,Albuquerque FC,Spetzler RF

    更新日期:2013-12-01 00:00:00

  • Congenital Dermal Sinus and Limited Dorsal Myeloschisis: "Spectrum Disorders" of Incomplete Dysjuction Between Cutaneous and Neural Ectoderms.

    abstract:BACKGROUND:The existence of tethering tracts in spinal dysraphism, other than congenital dermal sinus (CDS), has been recognized and has been summated into an integrated concept of limited dorsal myeloschisis (LDM). OBJECTIVE:To elucidate the underlying embryology of LDM in relation to CDS by focusing on the pathologi...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyy058

    authors: Lee JY,Park SH,Chong S,Phi JH,Kim SK,Cho BK,Wang KC

    更新日期:2019-02-01 00:00:00

  • Correlation of absorption coefficients with intracranial fluid protein concentrations and specific gravities.

    abstract::Samples of ventricular cerebrospinal fluid, tumor cyst fluid, and subdural fluid were obtained from 30 patients at operation. The protein concentration and the specific gravity of each sample were measured and the corresponding mean absorption numbers were calculated from the numerical printout of the preoperative com...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-197907010-00003

    authors: Salcman M

    更新日期:1979-07-01 00:00:00

  • Cervical spondylotic myelopathy, depression, and anxiety: a cohort analysis of 89 patients.

    abstract:OBJECTIVE:To determine the prevalence of depressed and anxious mood states in patients with cervical spondylotic myelopathy (CSM), a degenerative spine condition with symptoms of neck pain, numb clumsy hands, gait difficulties, sphincter dysfunction, and impotence. To examine the relation between mood and functional de...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000166664.19662.43

    authors: Stoffman MR,Roberts MS,King JT Jr

    更新日期:2005-08-01 00:00:00

  • Transdural approach to the anterior spinal canal in patients with cervical spondylotic myelopathy and superimposed central soft disc herniation.

    abstract::We present seven patients with multilevel cervical spondylotic myelopathy and superimposed midline soft disc herniation who were treated by decompressive laminectomies of the spondylotic segments followed by transdural excision of the anteriorly located disc extrusion. There was no perioperative neurological morbidity...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199404000-00010

    authors: Fox MW,Onofrio BM

    更新日期:1994-04-01 00:00:00

  • The neurosurgical workforce in North America: a critical review of gender issues.

    abstract:OBJECTIVE:The role of women in Western society has changed dramatically in the past several decades. Despite this, many gender disparities still exist for professionals in the health care sector. In neurosurgery, a disproportionately small percentage of the workforce in the United States and Canada is female. These fig...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.NEU.0000232671.44297.DF

    authors: Woodrow SI,Gilmer-Hill H,Rutka JT

    更新日期:2006-10-01 00:00:00

  • Computer-aided intelligence: application of an expert system to brachial plexus injuries.

    abstract::When confronted with a patient with a brachial plexus injury, how often as neurosurgeons do we consult an atlas to confirm the anatomy of the brachial plexus and then attempt to establish the location of the lesion? Similar difficulties are encountered with lumbar and sacral plexus lesions. In a project organized to a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Fisher WS 3rd

    更新日期:1990-11-01 00:00:00

  • Postoperative hydrocephalus in patients undergoing decompressive hemicraniectomy for ischemic or hemorrhagic stroke.

    abstract:OBJECTIVE:We have frequently observed the development of postoperative communicating hydrocephalus in patients undergoing decompressive hemicraniectomy. This condition may persist in some patients after cranioplasty and require permanent cerebrospinal fluid (CSF) diversion. To confirm an independent correlation between...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000290894.85072.37

    authors: Waziri A,Fusco D,Mayer SA,McKhann GM 2nd,Connolly ES Jr

    更新日期:2007-09-01 00:00:00

  • Combined pretemporal and endovascular approach to the cavernous sinus for the treatment of carotid-cavernous dural fistulae: technical case report.

    abstract:OBJECTIVE AND IMPORTANCE:The endovascular treatment of carotid-cavernous dural fistulae is becoming the prominent treatment modality for these lesions. The intractability of these lesions and their tendency to recur, especially after previous endovascular treatment sessions, exhausts the available routes and tends to p...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199902000-00113

    authors: Krisht AF,Burson T

    更新日期:1999-02-01 00:00:00

  • Change in ventricular size and effect of ventricular catheter placement in pediatric patients with shunted hydrocephalus.

    abstract:OBJECTIVE:The multicenter, randomized pediatric cerebrospinal fluid shunt valve design trial found no difference in the rate of shunt failure between a standard valve, a siphon-reducing valve (Delta; Medtronic PS Medical, Goleta, CA), and a flow-limiting valve (Orbis Sigma; Cordis, Miami, FL); however, the valves were ...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00006123-199912000-00012

    authors: Tuli S,O'Hayon B,Drake J,Clarke M,Kestle J

    更新日期:1999-12-01 00:00:00

  • The NASSAU (New ASSessment of cerebral Arteriovenous Malformations yet Unruptured) Analysis: Are the Results From The ARUBA Trial Also Applicable to Unruptured Arteriovenous Malformations Deemed Suitable for Gamma Knife Surgery?

    abstract:BACKGROUND:The optimal management of unruptured brain arteriovenous malformations (AVMs) is controversial after the ARUBA trial. OBJECTIVE:To confirm or repudiate the ARUBA conclusion that "medical management only is superior to medical management with interventional therapy for unruptured brain arteriovenous malforma...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyy391

    authors: Karlsson B,Jokura H,Yang HC,Yamamoto M,Martinez R,Kawagishi J,Guo WY,Beute G,Pan DHC,Aiyama H,Chung WY,Söderman M,Yeo TT

    更新日期:2019-07-01 00:00:00

  • Radiation therapy in the treatment of cerebral astrocytoma.

    abstract::With the advent of more sensitive diagnostic techniques, we are encountering an increasing number of young patients harboring cerebral astrocytoma. The great danger in such patients is that the astrocytoma cells will undergo dedifferentiation to a higher state of malignancy. An essential question is whether the use of...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198706000-00028

    authors: Morantz RA

    更新日期:1987-06-01 00:00:00

  • Ruptured cerebral aneurysms missed by initial angiographic study.

    abstract::The authors reviewed the computed tomographic (CT) scans of patients with subarachnoid hemorrhage whose initial angiograms were negative, to investigate the validity of CT scans in predicting the presence of an angiographically missed aneurysm in such patients. During the past 14 years, additional angiograms have been...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199007000-00006

    authors: Iwanaga H,Wakai S,Ochiai C,Narita J,Inoh S,Nagai M

    更新日期:1990-07-01 00:00:00

  • An alternative ultrasonographic approach to assess basilar artery flow.

    abstract:BACKGROUND:Assessment of basilar artery blood flow is of interest in many neurosurgical situations. With use of ultrasonography, the standard posterior approach is difficult in neurointensive care. OBJECTIVE:To evaluate the accuracy of an alternative submandibular approach for the assessment of blood flow in the basil...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e3182124835

    authors: Geeraerts T,Thome W,Tanaka S,Leblanc PE,Duranteau J,Vigué B

    更新日期:2011-06-01 00:00:00

  • Microsurgical removal of intraventricular lesions using endoscopic visualization and stereotactic guidance.

    abstract:OBJECTIVE:To demonstrate the technique of stereotactic microsurgical endoscopic removal of intraventricular tumors or colloid cysts assisted by intraoperative computed tomography. METHODS:We adapted a tubular "ventriculoport" for stereotactic insertion of an endoscope into the ventricle. This facilitated microsurgical...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000146227.75138.08

    authors: Harris AE,Hadjipanayis CG,Lunsford LD,Lunsford AK,Kassam AB

    更新日期:2005-01-01 00:00:00

  • Duplication of the abducens nerve at the petroclival region: an anatomic study.

    abstract:OBJECTIVE:During its course between the brainstem and the lateral rectus muscle, the abducens nerve usually travels forward as a single trunk, but it is not uncommon for the nerve to split into two branches. The objective of this study was to establish the incidence and the clinical importance of the duplication of the...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000048186.18741.3c

    authors: Ozveren MF,Sam B,Akdemir I,Alkan A,Tekdemir I,Deda H

    更新日期:2003-03-01 00:00:00

  • Percutaneous minidose metrizamide endomyelographic computed tomography in syringomyelia.

    abstract::Two patients presented with syringomyelia, each unusual. After neuroradiographic diagnosis with delayed metrizamide computed tomography (CT) or magnetic resonance imaging (MRI), an interesting diagnostic question arose. A percutaneous minidose metrizamide endomyelographic CT (PMDMECT) study clarified each situation an...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198703000-00013

    authors: Blumenkopf B

    更新日期:1987-03-01 00:00:00

  • Special aspects of diagnostic imaging for radiosurgery of arteriovenous malformations.

    abstract:OBJECTIVE:Radiosurgery can be considered a well-established option for the treatment of arteriovenous malformations (AVMs). The exact application of the therapeutic dose is based on the availability of imaging data sets with superior image quality that can be superimposed using an image fusion algorithm. For follow-up ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000325936.00982.0a

    authors: Hamm KD,Klisch J,Surber G,Kleinert G,Eger C,Aschenbach R

    更新日期:2008-05-01 00:00:00

  • Spinal epidural teratoma: review of spinal teratoma with consideration on the pathogenesis: case report.

    abstract:BACKGROUND AND IMPORTANCE:Of the 170 cases of teratomas in the spinal canal reported in the English literature, only 13 were spinal epidural teratomas (SETs). We present a case of SET, review the characteristics of SETs in comparison with spinal intradural teratomas (SITs), and investigate the pathogenesis of spinal te...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/NEU.0b013e3181f846ca

    authors: Park SC,Kim KJ,Wang KC,Choe G,Kim HJ

    更新日期:2010-12-01 00:00:00

  • Lysis of intraventricular blood clot with urokinase in a canine model: Part 3. Effects of intraventricular urokinase on clot lysis and posthemorrhagic hydrocephalus.

    abstract::Nine millilitres of preclotted autologous blood was injected into the ventricles of 10 adult mongrel dogs (control dogs) to create subtotal ventricular casts with solid clots. The neurological status and systemic fibrinolytic profiles were closely monitored, and the changes in clot and ventricular volumes were measure...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198610000-00010

    authors: Pang D,Sclabassi RJ,Horton JA

    更新日期:1986-10-01 00:00:00

  • Pediatric pituitary tumors.

    abstract::This retrospective review of pediatric patients with pituitary tumors causing onset of symptoms by 17 years of age was done to define their pathological distribution, clinical presentation, treatment, and prognosis. Eighteen patients were evaluated and treated from 1979 to 1989. Five had Cushing's disease and 13 had p...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199110000-00004

    authors: Haddad SF,VanGilder JC,Menezes AH

    更新日期:1991-10-01 00:00:00

  • Anatomy of the superior ophthalmic vein approach for direct endovascular access to vascular lesions of the orbit and cavernous sinus.

    abstract:OBJECTIVE:The superior ophthalmic vein (SOV) provides an alternative venous access for the treatment of carotid-cavernous fistulae. Its direct surgical exposure and cannulation can be difficult. This study was performed to identify anatomic landmarks to facilitate localization and exposure of the SOV. METHODS:The vasc...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000340781.34122.A2

    authors: Reis CV,Gonzalez FL,Zabramski JM,Hassan A,Deshmukh P,Albuquerque FC,Preul MC

    更新日期:2009-05-01 00:00:00

  • Reflections on nuclear warfare.

    abstract::The author looks back on his more than 70 years of familiarity with Americans involved in warfare, noting their loyal support for our country's objectives. Drawing on the Einstein equation, his own visits to Hiroshima and Nagasaki, and current literature, he, as a physician, belatedly concurs with those who look on th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198304000-00001

    authors: Evans JP

    更新日期:1983-04-01 00:00:00

  • Comparison of clinical result between microsurgical and direct visual intracranial aneurysm surgery.

    abstract::A retrospective study of 119 operative procedures for intracranial aneurysm was performed to compare the clinical result with microsurgical technique vs. that with standard instruments and without magnification; the operative technique was the major variable. The study demonstrated more normal patients, less intraoper...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198204000-00001

    authors: Leibrock LG,Epstein MH,Long D

    更新日期:1982-04-01 00:00:00

  • What makes surgical tumor resection feasible in Broca's area? Insights into intraoperative brain mapping.

    abstract:OBJECTIVE:Surgical resection of mass lesions in Broca's area is controversial. To demonstrate that pathology may influence the localization of functional areas and language performance, we reviewed our experience of awake craniotomies in Broca's area. METHODS:Sixteen consecutive patients who underwent awake craniotomy...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000368442.92290.04

    authors: Lubrano V,Draper L,Roux FE

    更新日期:2010-05-01 00:00:00