Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia.

abstract：:Collagen gel was used as a substance for the assay of human granulocyte-macrophage colony-forming units (CFUc). The number of colonies formed in collagen gel was consistently higher than that in a conventional soft-agar system. In six out of eight experiments, the difference was statistically significant. Whole perman...

journal_title：Experimental hematology

authors： Suda T,Nemoto K,Izumi T,Miyawaki S,Maekawa T

更新日期：1984-05-01 00:00:00

abstract：:An evaluation of the effectiveness of a genetically engineered recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3) fusion protein (FP) as a means of delivering cytokine combinations to megakaryocyte (MK) progenitor cells was performed, utilizing a serum-depleted clonal assay syst...

journal_title：Experimental hematology

authors： Bruno E,Briddell RA,Cooper RJ,Brandt JE,Hoffman R

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:Hematopoietic stem cells (enriched in fraction of CD34+ cells) have the ability to regenerate hematopoiesis in all of its lineages, and this potential is clinically used in transplanting bone marrow or peripheral blood stem cells. Our objective was to assemble a suitable method for evaluating gene expression ...

journal_title：Experimental hematology

authors： Koutna I,Klabusay M,Kohutova V,Krontorad P,Svoboda Z,Kozubek M,Mayer J

更新日期：2006-07-01 00:00:00

abstract：:Our previous studies have shown that a unique glycoprotease from Pasteurella haemolytica specifically cleaves only proteins containing sialylated O-linked glycans. The hematopoietic progenitor cell antigen, CD34, which is heavily glycosylated with both N- and O-linked glycans, is readily cleaved by this protease. In t...

journal_title：Experimental hematology

authors： Sutherland DR,Marsh JC,Davidson J,Baker MA,Keating A,Mellors A

更新日期：1992-06-01 00:00:00

abstract：:A transplanted tumor that induces granulocytosis and produces colony stimulating factor (CSF) was studied in mice during several passages. The sequence of events leading to granulocytosis was characterized. Band granulocytes were increased 3 days after tumor inoculation, while simultaneously CFU-s and CFU-c in bone ma...

journal_title：Experimental hematology

authors： Reincke U,Burlington H,Carsten AL,Cronkite EP,Laissue JA

更新日期：1978-04-01 00:00:00

abstract：OBJECTIVE:Mobilized peripheral blood (PB) progenitors are increasingly used in autologous and allogeneic transplantation. However, the short- and long-term engraftment potential of mobilized PB or bone marrow (BM) has not been directly compared. Although several studies showed that BM-derived Lin(-)CD34(-) cells contai...

journal_title：Experimental hematology

authors： Verfaillie CM,Almeida-Porada G,Wissink S,Zanjani ED

更新日期：2000-09-01 00:00:00

abstract：:Nasal natural killer-T cell lymphoma (NNKTL) is associated with the Epstein-Barr virus and has distinct histologic features, such as angiocentric and polymorphous lymphoreticular infiltrates that contain too many cell types, including tumor and inflammatory cells. We have shown previously that intercellular adhesion m...

journal_title：Experimental hematology

authors： Takahara M,Nagato T,Komabayashi Y,Yoshino K,Ueda S,Kishibe K,Harabuchi Y

更新日期：2013-08-01 00:00:00

abstract：:Arsenic trioxide (As2O3) has been demonstrated to be effective for the treatment of acute promyelocytic leukemia (APL) and to inhibit proliferation and produce apoptosis in the APL cell line NB4. To determine if As2O3 might be useful for the treatment of other lineages, we investigated the effects of As2O3 on viabilit...

journal_title：Experimental hematology

authors： Lu M,Levin J,Sulpice E,Sequeira-Le Grand A,Alemany M,Caen JP,Han ZC

更新日期：1999-05-01 00:00:00

abstract：UNLABELLED:OBJECTIVE, METHODS, AND RESULTS: To reduce the period of posttransplant neutropenia and related early morbidity and mortality of cord blood (CB) transplants, we assessed the feasibility of co-infusion of a low number of highly purified peripheral blood CD34+ cells from a related haploidentical donor with a C...

journal_title：Experimental hematology

authors： Fernández MN,Regidor C,Cabrera R,García-Marco JA,Forés R,Sanjuán I,Gayoso J,Gil S,Ruíz E,Little AM,McWhinnie A,Madrigal A

更新日期：2003-06-01 00:00:00

abstract：:We have recently shown that interleukin 6 (IL-6) induces transient expression of the alpha-chain of the interleukin 2 receptor (IL-2R alpha) in the murine leukemia myeloid M1 cell line. Others have reported that IL-6 and interleukin 1 (IL-1) synergistically enhance the expression of IL-2R alpha in T cells. Thus, in th...

journal_title：Experimental hematology

authors： Ruhl S,Schwabe M,Pluznik DH

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:The CD15 (Lewis x) cell surface oligosaccharide moiety is expressed in a variety of normal and tumor cells and recognized by selectins. The detection of CD15 on malignant Hodgkin-Reed-Sternberg (HRS) cells serves as a diagnostic marker of Hodgkin's lymphoma (HL). Retrospective studies suggest that the express...

journal_title：Experimental hematology

authors： Ohana-Malka O,Benharroch D,Isakov N,Prinsloo I,Shubinsky G,Sacks M,Gopas J

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:We monitored cytokine-secreting cells using an enzyme-linked immunospot (ELISPOT) assay in a prospective study to assess the cytokine network after transplantation. PATIENTS AND METHODS:Peripheral blood mononuclear cells were collected from 23 patients who received allogeneic stem cell transplantation, from ...

journal_title：Experimental hematology

authors： Takabayashi M,Kanamori H,Takasaki H,Yamaji S,Koharazawa H,Taguchi J,Tomita N,Fujimaki K,Fujisawa S,Maruta A,Ishigatsubo Y

更新日期：2005-02-01 00:00:00

abstract：:Peritoneal injection of thioglycollate medium (TM) to mice results in a dramatic increase in total number of peritoneal macrophages within 48 to 72 hours. Unlike resident macrophages, a fraction (10 to 20%) of these newly arrived young macrophages, designated as macrophage colony-forming cells (M-CFC), are highly prol...

journal_title：Experimental hematology

authors： Chen B,Chou TH,Sensenbrenner L

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:The cause of delayed hematopoietic reconstitution after umbilical cord blood transplantation (UCBT) remains controversial. We hypothesized that hematopoietic stem/progenitor cells (HS/PCs) from UCB have some defects of the homing-related molecules responsible for their slow engraftment. MATERIALS AND METHODS...

journal_title：Experimental hematology

authors： Zheng Y,Watanabe N,Nagamura-Inoue T,Igura K,Nagayama H,Tojo A,Tanosaki R,Takaue Y,Okamoto S,Takahashi TA

更新日期：2003-12-01 00:00:00

abstract：:Hematopoiesis in continuous bone marrow culture is dependent upon close-range interaction between hematopoietic cells and marrow-derived adherent cells. The latter have been shown to include a significant proportion of fibroblastic elements, synthesizing the attachment protein fibronectin. The role of fibronectin in c...

journal_title：Experimental hematology

authors： Bentley SA,Tralka TS

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVE:We previously demonstrated that CD8(+)/TCR(-) bone marrow cells facilitate engraftment of HSC in allogeneic recipients without causing graft-vs-host disease. Whether facilitating cells (FC) develop from T cells or represent a distinct lineage has not been determined. METHODS:In the present studies, we charac...

journal_title：Experimental hematology

authors： Grimes HL,Schanie CL,Huang Y,Cramer D,Rezzoug F,Fugier-Vivier I,Ildstad ST

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:To investigate whether Flk1(+)CD31(-)CD34(-) cells isolated from fetal bone marrow (BM) have characteristics of hemangioblasts, i.e., progenitors of endothelial and hematopoietic cells. MATERIALS AND METHODS:Mononuclear cells from fetal BM were negatively sorted by CD45, GlyA, and CD34 micromagnetic beads, t...

journal_title：Experimental hematology

authors： Guo H,Fang B,Liao L,Zhao Z,Liu J,Chen H,Hsu SH,Cui Q,Zhao RC

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:The evolutionarily conserved Kit receptor is vital for function of hematopoietic stem cells (HSC). Kit(W-41) (W-41) and Kit(W-42) (W-42) are single residue changes in the KIT intracellular phosphotransferase domain, while Kit(W-v) (W-v) is a single residue change in the ATP binding domain. This study tests ho...

journal_title：Experimental hematology

authors： Sharma Y,Astle CM,Harrison DE

更新日期：2007-02-01 00:00:00

abstract：:Merocyanine 540 (MC 540) is a photosensitizing dye with antineoplastic and antiviral properties. Because photoexcited MC 540 generates singlet molecular oxygen and possibly other reactive oxygen species there is concern that MC 540-mediated photosensitization may be mutagenic. In this paper, we report on the induction...

journal_title：Experimental hematology

authors： O'Brien JM,Sieber F

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:B-lineage acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia in lymphatic blastic phase in adults have poor prognoses despite intensive chemotherapy. Novel targeted treatment modalities emerge, but their evaluation requires relevant in vitro models of lymphoblastic leukemia. Presently available c...

journal_title：Experimental hematology

authors： Nijmeijer BA,Szuhai K,Goselink HM,van Schie ML,van der Burg M,de Jong D,Marijt EW,Ottmann OG,Willemze R,Falkenburg JH

更新日期：2009-03-01 00:00:00

abstract：:Peripheral blood and bone marrow specimens from patients with polycythemia vera (PV) and chronic myelogenous leukemia (CML) were assayed for erythroid and granulopoietic progenitor cells. All compartments were increased in CML patients in relapse although the ratio of BFU-E to CFU-C numbers remained constant in all CM...

journal_title：Experimental hematology

authors： Eaves AC,Henkelman DH,Eaves CJ

更新日期：1980-01-01 00:00:00

abstract：:Leukemia associated inhibitor, LAI, reversibly inhibits DNA synthesis in normal human granulocyte-macrophage colony-forming units (CFU-GM). LAI is produced by myeloid leukemia cells, a subpopulation of normal nonadherent low-density mononuclear cells in peripheral blood and bone marrow, as well as by the human promyel...

journal_title：Experimental hematology

authors： Olofsson T,Sallerfors B

更新日期：1987-12-01 00:00:00

abstract：:It is becoming increasingly clear that the adeno-associated virus 2 (AAV)-based vector system may prove to be useful for high-efficiency gene transfer in human cells as well as for potential gene therapy in humans. A recombinant AAV vector containing the gene for a human hematopoietic growth factor, granulocyte-macrop...

journal_title：Experimental hematology

authors： Luo F,Zhou SZ,Cooper S,Munshi NC,Boswell HS,Broxmeyer HE,Srivastava A

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:Beta-thalassemia results from beta-globin gene mutations that lead to ineffective erythropoiesis, shortened red cell survival, and anemia. Patients with beta-thalassemia develop iron overload, despite which, hepcidin levels are low. This suggests that hepcidin regulation in beta-thalassemia is more sensitive ...

journal_title：Experimental hematology

authors： Ginzburg YZ,Rybicki AC,Suzuka SM,Hall CB,Breuer W,Cabantchik ZI,Bouhassira EE,Fabry ME,Nagel RL

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Murine marrow cells are capable of repopulating skeletal muscle fibers. A point of concern has been the "robustness" of such conversions. We have investigated the impact of type of cell delivery, muscle injury, nature of delivered cell, and stem cell mobilizations on marrow-to-muscle conversion. METHODS:We t...

journal_title：Experimental hematology

authors： Abedi M,Greer DA,Colvin GA,Demers DA,Dooner MS,Harpel JA,Weier HU,Lambert JF,Quesenberry PJ

更新日期：2004-05-01 00:00:00

abstract：:We evaluated the expansion capacity of untreated and 5-fluorouracil (5-FU)-resistant peripheral blood stem cells (PBSC) after 7-day incubation with interleukin-1 (IL-1) plus IL-3 plus stem cell factor (SCF) or with medium alone. We found a significant increase in the proportion of CD34+ cells in the PBSC fraction resi...

journal_title：Experimental hematology

authors： Rice A,Boiron JM,Barbot C,Dupouy M,Dubosc-Marchenay N,Dumain P,Lacombe F,Reiffers J

更新日期：1995-04-01 00:00:00

abstract：:We studied the phenotypic and functional properties of colony-forming cells (CFCs), primitive long-term culture initiating cells (LTC-ICs) and lymphoid precursors present in human fetal liver (FL) and compared these with their adult bone marrow (BM) counterparts. FL (7-14-week) cells were selected by fluorescence-acti...

journal_title：Experimental hematology

authors： Roy V,Miller JS,Verfaillie CM

更新日期：1997-05-01 00:00:00

abstract：:The myeloproliferative neoplasms (MPNs) are somatic mutation-driven hematologic malignancies characterized by bone marrow fibrosis and the accumulation of atypical megakaryocytes with reduced polyploidization in the primary myelofibrosis subtype of the MPNs. Increasing evidence points to a dominant role of abnormal me...

journal_title：Experimental hematology

authors： Yang Q,Crispino JD,Wen QJ

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:We examined the stimulatory effect of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet production in male (NZW x BXSB) F(l) (W/B F(1)) mice, a murine model of idiopathic thrombocytopenic purpura. MATERIALS AND METHODS:A cohort of 19- to 25-week-old, severely t...

journal_title：Experimental hematology

authors： Shibuya K,Kuwaki T,Tahara E,Yuki C,Akahori H,Kato T,Miyazaki H

更新日期：2002-10-01 00:00:00

abstract：:Imatinib mesylate (IM), a tyrosine kinase inhibitor currently used in chronic myeloid leukemia (CML), may also affect the growth of other cellular systems besides CML cells. Because it has been reported that IM may affect bone tissue remodeling, we evaluated the effects of IM on osteoblastic differentiation of human b...

journal_title：Experimental hematology

authors： Tibullo D,Giallongo C,La Cava P,Berretta S,Stagno F,Chiarenza A,Conticello C,Palumbo GA,Di Raimondo F

更新日期：2009-04-01 00:00:00