A novel point-of-care device for measuring glucose-6-phosphate dehydrogenase enzyme deficiency.

Abstract:

:Extreme hyperbilirubinemia can cause bilirubin neurotoxicity. Infants with glucose-6-phosphate dehydrogenase (G6PD) deficiency can develop hemolysis and thus are at high risk. We evaluated a device that quantitatively measures G6PD activity kinetically using digital microfluidics (DMF). Intra- and inter-instrument and -day imprecision (CVs) were first assessed. G6PD activity in 86 samples was then measured and compared between DMF and 2 reference methods. Overall DMF reproducibility was 3.8% over 5 days by 2 operators on 2 instruments. Mean intra- and inter-instrument variabilities were 3.6% and 3.9%, respectively (n = 28), with a user variability of 4.3%. Mean G6PD activity was 6.40±4.62 and 6.37±4.62 U/g hemoglobin for DMF and Reference Methods 1 (n = 46) and 12.15±3.86 and 11.48±1.55 for DMF and 2 (n = 40), respectively, and strongly correlated (r = 0.95 and 0.95) with mean biases of +0.04±2.90 and +0.67±1.55 for methods 1 and 2, respectively. The novel device could be used for early newborn G6PD screening.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Wong RJ,Montiel C,Kunda M,Stevenson DK,Bhutani VK

doi

10.1016/j.semperi.2020.151356

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

151356

issue

1

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(20)30139-7

journal_volume

45

pub_type

杂志文章
  • Rhesus disease in Brazil: A multi-professional national survey.

    abstract::Universal prenatal Rhesus (Rh) screening and prophylaxis with Rh immunoglobulin have been highly effective practices for preventing neonatal morbidities and mortality. However, there has been an enormous failure to prevent Rh sensitization and its adverse consequences worldwide, especially in low- and middle-income co...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1016/j.semperi.2020.151357

    authors: Variane GF,Sant'Anna GM

    更新日期:2021-02-01 00:00:00

  • The outpatient management and special considerations of nausea and vomiting in pregnancy.

    abstract::With 50-90% of pregnant women experiencing nausea and vomiting of pregnancy (NVP), the burden of illness can become quite significant if symptoms are under-treated and/or under-diagnosed, thus allowing for progression of the disease. The majority of these women will necessitate at least one visit with a provider to sp...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2014.08.014

    authors: Clark SM,Dutta E,Hankins GD

    更新日期:2014-12-01 00:00:00

  • Amniotic fluid volume and its relationship to fetal fluid balance: review of experimental data.

    abstract::The studies described above collectively suggest that, whenever there is a decrease in fluid balance in the fetus, both fetal urine flow and tracheal secretion into the amniotic space are decreased. Conversely, when fetal hydration is increased, both urine and tracheal flows into the amniotic fluid may be increased. T...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Brace RA

    更新日期:1986-04-01 00:00:00

  • Cesarean section on demand.

    abstract::The safety of cesarean section has improved dramatically over the past 50 years. During the past 20 years a greater awareness of and discussion about the symptomatic morbidity that can result for women following vaginal delivery has occurred and women's expectations for the outcome of pregnancy for them and their babi...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/sper.2003.50002

    authors: Morrison J,MacKenzie IZ

    更新日期:2003-02-01 00:00:00

  • Benefits and risks of MRI in pregnancy.

    abstract::Ultrasound remains the modality of choice in imaging the fetus due to its availability, safety, and low cost. With advances in technology, however, magnetic resonance imaging (MRI) has become an important adjuvant in the evaluation of the fetus. MRI is not limited by fetal lie, oligohydramnios, overlying bone, or obes...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2013.06.005

    authors: Bulas D,Egloff A

    更新日期:2013-10-01 00:00:00

  • Prediction and prevention of spontaneous preterm birth in twin gestations.

    abstract::The incidence of twin gestation has increased significantly over the past 30 years. One of the most significant public health implications of this trend is the increased incidence of preterm birth (PTB). Efforts to improve neonatal outcomes must address the rate of PTB, particularly among multiple gestations, which co...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.02.003

    authors: Brubaker SG,Gyamfi C

    更新日期:2012-06-01 00:00:00

  • Phototherapy for neonatal jaundice--therapeutic effects on more than one level?

    abstract::Phototherapy for jaundice is a common treatment in neonatal medicine and is used to prevent the neurotoxic effects of bilirubin. Studies have assessed the optimal wavelength of phototherapy light, the importance of irradiance and spectral power, and the types of light source, including the use of single versus multipl...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2010.02.008

    authors: Ruud Hansen TW

    更新日期:2010-06-01 00:00:00

  • Nitric oxide and pregnancy.

    abstract::We have hypothesized that an alteration in the production of endothelium-dependent factors by sex hormones is a potential unifying mechanism for both the decreased arterial contractility and the redistribution of cardiac output characteristic of normal pregnancy. Thus, the effect of pregnancy/ estradiol on any one vas...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(97)80003-1

    authors: Weiner CP,Thompson LP

    更新日期:1997-10-01 00:00:00

  • Substrate metabolism in the developing heart.

    abstract::The developing heart undergoes a remarkable metabolic transformation as it adjusts to the higher-oxygen, extrauterine environment. During gestation, glycolysis and lactate oxidation constitute the major sources of adenosine triphosphate (ATP) for the fetal heart. After birth, however, there is a rapid shift from carbo...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(96)80068-1

    authors: Ascuitto RJ,Ross-Ascuitto NT

    更新日期:1996-12-01 00:00:00

  • Sleep-disordered breathing and future cardiovascular disease risk.

    abstract::Sleep-disordered breathing occurs in 0.6-15% of reproductive age women. This condition is associated with an increased lifetime risk of cardiovascular disease, cardiovascular mortality, and all-cause mortality. A substantial body of evidence demonstrated increased perinatal morbidity among pregnancies affected by SDB ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2015.05.010

    authors: Cain MA,Ricciuti J,Louis JM

    更新日期:2015-06-01 00:00:00

  • The origins of stillbirth: infectious diseases.

    abstract::This article reviews the literature on infectious diseases as a cause of stillbirth. Identifying a specific infection as a cause of stillbirth is limited by many obstacles. Nevertheless, "good faith" efforts estimate that approximately 9% to 15% of stillbirths are caused by infections. Infection may be especially impo...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/sper.2002.29839

    authors: Gibbs RS

    更新日期:2002-02-01 00:00:00

  • The role of erythropoietin in the anemia of prematurity.

    abstract::Neonatal erythropoiesis is limited by a relatively inadequate production of erythropoietin. This is likely the result of dependence on the hepatic production of erythropoietin and an incomplete switchover to renal production. The present model of neonatal erythropoiesis suggests that the use of exogenous erythropoieti...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(97)80016-x

    authors: Doyle JJ

    更新日期:1997-02-01 00:00:00

  • Customized fetal growth standards: rationale and clinical application.

    abstract::Accurate assessment of fetal growth status requires the definition of an optimal standard, which represents the growth potential of the baby. Against this standard, individually 'customized' percentiles can be calculated. They improve the distinction between normal and abnormal, and help in our understanding and diagn...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2003.12.002

    authors: Gardosi J

    更新日期:2004-02-01 00:00:00

  • Treatment and prophylaxis of invasive candidiasis.

    abstract::Invasive candidiasis (IC) is a leading cause of morbidity and mortality in preterm infants. Even if successfully treated, IC can cause significant neurodevelopmental impairment. Preterm infants are at increased risk for hematogenous Candida meningoencephalitis owing to increased permeability of the blood-brain barrier...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.06.003

    authors: Tripathi N,Watt K,Benjamin DK Jr

    更新日期:2012-12-01 00:00:00

  • The newborn with ambiguous genitalia.

    abstract::The unexpectedness of genital ambiguity in an infant creates an urgent and stressful situation. A logical approach, using a team of specialists together with nursery staff and physicians, allows each member to contribute expertise and unnecessary overlap of investigations. The psychological needs of the parents should...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: McGillivray BC

    更新日期:1992-12-01 00:00:00

  • Community-informed models of perinatal and reproductive health services provision: A justice-centered paradigm toward equity among Black birthing communities.

    abstract::Perinatal health outcomes in the United States continue to worsen, with the greatest burden of inequity falling on Black birthing communities. Despite transdisciplinary literature citing structural racism as a root cause of inequity, interventions continue to be mostly physician-centered models of perinatal and reprod...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semperi.2020.151267

    authors: Julian Z,Robles D,Whetstone S,Perritt JB,Jackson AV,Hardeman RR,Scott KA

    更新日期:2020-08-01 00:00:00

  • Amniotic fluid abnormalities.

    abstract::The complex nature of amniotic fluid reflects contributions from many fetal systems, many functional roles, and multiple interactions with fetal maturation, obstetric, and maternal factors. Simple ultrasound measurement, probably done best with the maximum vertical pocket method, has a clinical role in fetal surveilla...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2008.04.012

    authors: Harman CR

    更新日期:2008-08-01 00:00:00

  • Placental transfer of selected substances of abuse.

    abstract::The placenta was classically considered a barrier, but in 1957 this notion was shattered. This organ is only a selective filter and metabolic site. In this review, the placental transfer of the top 17 substances of abuse are analyzed. In the National Library of Medicine only 41 papers that documented placental transfe...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(96)80082-6

    authors: Little BB,VanBeveren TT

    更新日期:1996-04-01 00:00:00

  • Postnatal weight gain and retinopathy of prematurity.

    abstract::Infants meeting retinopathy of prematurity (ROP) screening guidelines based on birth weight and gestational age undergo serial examinations by ophthalmologists for detection and treatment. However, less than 10% require treatment, and less than half develop ROP. Slow postnatal weight gain is highly predictive of ROP, ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2019.05.008

    authors: Lin L,Binenbaum G

    更新日期:2019-10-01 00:00:00

  • Nutrition and maternal, neonatal, and child health.

    abstract::This article reviews the central role of nutrition in advancing the maternal, newborn, and child health agenda with a focus on evidence for effective interventions generated using randomized controlled trials in low- and middle-income countries (LMIC). The 1000 days spanning from conception to 2 years of life are a cr...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2015.06.009

    authors: Christian P,Mullany LC,Hurley KM,Katz J,Black RE

    更新日期:2015-08-01 00:00:00

  • Diagnostic errors in the neonatal intensive care unit: State of the science and new directions.

    abstract::Diagnostic errors remain understudied in neonatology. The limited available evidence, however, suggests that diagnostic errors in the neonatal intensive care unit (NICU) result in significant and long-term consequences. In this narrative review, we discuss how the concept of diagnostic errors framed as missed opportun...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2019.08.004

    authors: Shafer G,Singh H,Suresh G

    更新日期:2019-12-01 00:00:00

  • Thyroid hormone regulation of perinatal cardiovascular function.

    abstract::Thyroid hormone plays an important role in regulating cardiovascular function during the transition to extrauterine physiology. Multiple mechanisms participate, ranging from transcriptional to more immediate nongenomic modes of regulation. ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2008.09.007

    authors: Portman MA

    更新日期:2008-12-01 00:00:00

  • Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity.

    abstract::Retinopathy of Prematurity (ROP) is a preventable neovascular retinal disease with a lifetime impact on vision and ocular morbidities. Retinal vessel immaturity and oxygen therapy, influenced or modulated by several risk factors including oxidative stress, intermittent hypoxia and desaturations, inflammation, infectio...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2019.05.009

    authors: Aranda JV,Qu J,Valencia GB,Beharry KD

    更新日期:2019-10-01 00:00:00

  • Population trends in sudden infant death syndrome.

    abstract::This review documents and assesses recent trends in sudden infant death syndrome. We review medical literature, Internet resources, and national governmental data. A striking reduction in SIDS incidence of more than 50% has been observed in various countries after interventions, particularly during the early 1990s, to...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/sper.2002.34774

    authors: Ponsonby AL,Dwyer T,Cochrane J

    更新日期:2002-08-01 00:00:00

  • The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit.

    abstract::Nonsteroidal anti-inflammatory drugs are frequently used during pregnancy (premature labor, polyhydramnios) and the immediate postnatal period (closure of patent ductus arteriosus). This article evaluates the renal effect of 3 nonspecific COX inhibitors (aspirin, indomethacin, and ibuprofen) in newborn rabbits. Five g...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/sper.2002.37310

    authors: Guignard JP

    更新日期:2002-12-01 00:00:00

  • After shoulder dystocia: managing the subsequent pregnancy and delivery.

    abstract::Among risk factors for shoulder dystocia, a prior history of delivery complicated by shoulder dystocia is the single greatest risk factor for shoulder dystocia occurrence, with odds ratios 7 to 10 times that of the general population. Recurrence rates have been reported to be as high as 16%. Whereas prevention of shou...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2007.03.009

    authors: Gurewitsch ED,Johnson TL,Allen RH

    更新日期:2007-06-01 00:00:00

  • Suppression of lactation.

    abstract::Medical and psychological indications for lactation suppression are discussed, and methods for lactation suppression are evaluated. Medical indications for lactation suppression include 1) maternal anatomical abnormalities, such as inadequate secretory tissue and inverted nipples; 2) maternal breast infections and tu...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Harrison RG

    更新日期:1979-07-01 00:00:00

  • Theoretical foundations of learning through simulation.

    abstract::Health care simulation is a powerful educational tool to help facilitate learning for clinicians and change their practice to improve patient outcomes and safety. To promote effective life-long learning through simulation, the educator needs to consider individuals, their experiences, and their environments. Effective...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2011.01.002

    authors: Zigmont JJ,Kappus LJ,Sudikoff SN

    更新日期:2011-04-01 00:00:00

  • A new tool for prenatal diagnosis: ultrafast fetal MRI.

    abstract::The development of ultrafast magnetic resonance imaging scanners and sequences provides a new tool for the diagnosis of fetal anomalies. Magnetic resonance imaging is a valuable adjunct to prenatal ultrasound especially for the evaluation of suspected fetal brain anomalies, chest masses, abdominal masses, and renal di...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(99)80023-8

    authors: Hubbard AM,Harty MP,States LJ

    更新日期:1999-12-01 00:00:00

  • Auditory impairment in infants at risk for bilirubin-induced neurologic dysfunction.

    abstract::Classical and subtypes of kernicterus associated with bilirubin toxicity can be differentiated in part with physiological auditory measures that include auditory-evoked potentials and measures of cochlear integrity. The combination of these auditory measures suggests that bilirubin exposure results in auditory system ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2011.02.011

    authors: Shapiro SM,Popelka GR

    更新日期:2011-06-01 00:00:00