Abstract:
PURPOSE:To investigate the role of urinary neutrophil gelatinase-induced lipocalin (uNGAL) measurement in the early diagnosis of acute kidney injury that may occur after intraoperative ischemia in patients undergoing partial nephrectomy (PN). METHODS:This prospective study included 86 patients who underwent open laparoscopic or robotic partial nephrectomy between May 2017 and May 2019. During the surgery, whether the patients had ischemia or not, type of vascular clamping and the ischemia time were noted. The definition of acute kidney injury (AKI) was classified according to Acute Kidney Injury Network (AKIN) criteria. Urine samples were collected preoperatively and 3 h after renal pedicle clamp removal and uNGAL was measured. RESULTS:AKI was recorded in 34 (39.5%) of 86 patients after PN. Of the 34 patients, 26 (76.4%) had level 1 and 8 (23.6%) had level 2 AKI. uNGAL levels increased significantly as an early reflection of AKI in patients who underwent intraoperative total or renal artery clamping (p = 0.024). There was no significant postoperative increase in uNGAL in the non-ischemic group (p = 0.163). uNGAL expression was detected well before serum creatinine increase. Patients with AKI after PN had higher uNGAL expression (p = 0.008) However, there was no correlation between the level of AKI and uNGAL expression (r = 0.201, p = 0.066). CONCLUSION:Ischemic acute kidney injury after nephron-sparing surgery can be detected early by uNGAL measurement. In future studies comparing outcomes of different surgical techniques on renal functions after PN, uNGAL levels may be used.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Akpinar C,Dogan O,Kubilay E,Gokce MI,Suer E,Gulpinar O,Baltaci Sdoi
10.1007/s11255-020-02660-2subject
Has Abstractpub_date
2020-09-26 00:00:00eissn
0301-1623issn
1573-2584pii
10.1007/s11255-020-02660-2pub_type
杂志文章abstract::Lymphocyte suppressive activity after stimulation with Con A and lymphocyte function as the effectors in the ADCC test had been examined in 68 patients with chronic glomerulonephritis (GN) and in 20 healthy controls. Lymphocyte suppressive activity was lower in patients with chronic GN than in the healthy individuals....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082111
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:There is evidence that chronic local ischemia may be one possible etiology of prostatic atrophy (PA). Our aim was to study the expression of hypoxia induced factors in areas of PA. DESIGN:The immunohistochemical expression of hypoxia-inducible factor-1 alpha (HIF-1) and vascular endothelial growth factor (V...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
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journal_title:International urology and nephrology
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abstract::The vesical stone formation due to intravesical mesh erosion of tension-free vaginal tape (TVT) is rare. In this report, a case of 48-year-old patient who underwent (TVT) elsewhere is discussed. The patient was presented with vesical stone and persistent stress urinary incontinence. Intravesical stone was detected by ...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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doi:
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abstract::Most of the purported links between microbial agents and primary small-vessel anti-neutrophilic antibody-positive (ANCA) vasculitides remain speculative. There is strong circumstantial evidence for the role of Staphylococcus aureus in the development of Wegener's granulomatosis, but its role in other ANCA-positive vas...
journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
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abstract:OBJECTIVE:The authors observed priapism as a side effect occuring during the intracavernous treatment of erectile dysfunction. Earlier priapism had been treated with an intracavernous injection of sympatomimetics; unfortunately several complications and contraindications were found. PATIENTS AND METHODS:Methylene blue...
journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550418
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abstract::In this study, 31 (30%) cases of urinary tract infection (UTI) of 103 patients with malnutrition, who were admitted to our hospital, were investigated prospectively. Our purpose was to determine the frequency of UTI, species of bacteria caused to infection and their antibiotic susceptibility in infants with malnutriti...
journal_title:International urology and nephrology
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pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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abstract::This study compares the safety and efficacy of mechanical cystolithotripsy (MCLT) and extracorporeal shock wave lithotripsy (ESWL) in the treatment of vesical stones. In the last four years we have treated 144 bladder lithiasis patients with MCLT (86; group A) and ESWL (58; group B). All patients in group A were treat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768241
更新日期:1994-01-01 00:00:00
abstract::Persistent Mullerian duct syndrome (PMDS) is a rare form of the 46 XY disorders of sexual differentiation, characterized by the presence of a uterus and fallopian tubes due to the failure of Mullerian duct regression in genotypically normal males. More than 150 cases have been recorded, most of them in adults. In most...
journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0030-y
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Cognitive dysfunction (CO/DY) in chronic kidney disease (CKD) patients has long been recognized. Hypertension is also associated with CO/DY. The study describes associated factors with CO/DY in CKD patients compared to hypertensive subjects. METHODS:Ninety-six hypertensive subjects without CKD, 19 patients wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0845-4
更新日期:2015-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1381-1
更新日期:2016-11-01 00:00:00