Abstract:
BACKGROUND:Care of children with functionally univentricular hearts is resource-intensive. OBJECTIVES:To analyse pregnancy and early post-natal outcomes of fetuses with functionally univentricular hearts in the setting of a low-middle-income country. METHODS:A retrospective study was conducted during the period of January 2008-October 2019. Study variables analysed included gestational age at diagnosis, maternal and fetal comorbidities and cardiac diagnosis including morphologic type of single ventricle. Outcomes analysed included pregnancy outcomes, type of post-natal care and survival status on the last follow-up. RESULTS:A total of 504 fetuses were included. Mean maternal age was 27.5 ± 4.8 years and mean gestational age at diagnosis was 25.6 ± 5.7 weeks. Pregnancy outcomes included non-continued pregnancies (54%), live births (42.7%) and loss to follow-up (3.3%). Gestational age at diagnosis was the only factor that impacted pregnancy outcomes (non-continued pregnancies 22.5 ± 3.5 vs. live births 29.7 ± 5.7 weeks; p < 0.001). Of the 215 live births, intention-to-treat was reported in 119 (55.3%) cases; of these 103 (86.6%) underwent cardiac procedures. Seventy-nine patients (36.7%) opted for comfort care. On follow-up (median 10 (1-120) months), 106 patients (21%) were alive. Parental choice of intention-to-.treat or comfort care was the only factor that impacted survival on follow-up. CONCLUSIONS:Prenatal diagnosis of functionally univentricular hearts was associated with overall low survival status on follow-up due to parental decisions on not to continue pregnancy or non-intention-to-treat after birth. Early detection of these complex defects by improved prenatal screening can enhance parental options and reduce resource impact in low-and-middle-income countries.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Vaidyanathan B,Vijayaraghavan A,Thomas S,Sudhakar Adoi
10.1017/S1047951120002929subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1844-1850issue
12eissn
1047-9511issn
1467-1107pii
S1047951120002929journal_volume
30pub_type
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journal_title:Cardiology in the young
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doi:10.1017/S1047951113001091
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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doi:10.1017/S1047951110001344
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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更新日期:2003-06-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 临床试验,杂志文章
doi:10.1017/s1047951100008349
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
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更新日期:2016-02-01 00:00:00
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journal_title:Cardiology in the young
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