Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review.

Abstract:

:In approximately 5% of patients with idiopathic recurrent pericarditis, the disease usually follows a chronic relapsing course, and children can develop dependence and side effects of prolonged high-dose corticosteroid regimens. In this setting anakinra, a recombinant human interleukin-1 competitive receptor antagonist that blocks the biologic effects of interleukin-1, thereby reducing systemic inflammatory responses, appears to be one of the most promising strategies. We report an adolescent with steroid-dependent idiopathic recurrent pericarditis that was successfully treated with anakinra, highlighting that this therapeutic option seems to be an effective, rapidly acting, steroid-sparing, and relatively safe agent for the treatment of this entity in children.

journal_name

Cardiol Young

journal_title

Cardiology in the young

authors

Rodriguez-Gonzalez M,Ruiz-Gonzalez E,Castellano-Martinez A

doi

10.1017/S1047951118002020

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

241-243

issue

2

eissn

1047-9511

issn

1467-1107

pii

S1047951118002020

journal_volume

29

pub_type

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