Abstract:
OBJECTIVE:The aim of the present study was to determine the role of toxic elements and trace elements in the pathogenesis of conotruncal heart defects by measuring their concentrations in the first meconium specimens of the affected newborns. METHODS:Concentrations of lead, cadmium, iron, zinc, and copper were measured in 1st-day meconium specimens that were collected from 60 newborns with conotruncal heart defects (Group I) and 72 healthy newborns (Group II). RESULTS:The newborns with conotruncal defects and the healthy newborns had statistically similar demographic and clinical characteristics. When compared with healthy newborns, mean concentrations of lead, cadmium, iron, zinc, and copper were significantly higher in newborns with conotruncal heart defects (p=0.001 for each). In total, 51 newborns with conotruncal heart defects had normal karyotype. These newborns had significantly higher concentrations of lead, cadmium, iron, zinc, and copper when compared with healthy newborns. There were significant and positive correlations between the concentrations of lead and cadmium (r=0.618, p=0.001), lead and iron (r=0.368, p=0.001), lead and zinc (r=0.245, p=0.005), lead and copper (r=0.291, p=0.001), cadmium and iron (r=0.485, p=0.001), cadmium and zinc (r=0.386, p=0.001), and cadmium and copper (r=0.329, p=0.001). CONCLUSION:Toxic metals and trace elements may disturb DNA repair mechanisms by impairing DNA methylation profiles, and thus have a role in the pathogenesis of conotruncal heart defects.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Kundak AA,Pektas A,Zenciroglu A,Ozdemir S,Barutcu UB,Orun UA,Okumus Ndoi
10.1017/S1047951116000536subject
Has Abstractpub_date
2017-03-01 00:00:00pages
312-317issue
2eissn
1047-9511issn
1467-1107pii
S1047951116000536journal_volume
27pub_type
杂志文章abstract::In this study, we summarise a case of a myofibroma causing mid-aortic syndrome due to obstruction of the distal thoracic and abdominal aorta leading to severe left ventricular dysfunction. The patient was managed with percutaneous intervention via balloon dilation and stent placement. On follow-up, the patient has nor...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001936
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated structural changes in the heart and cardiac dysfunction in foetuses with intrauterine growth restriction. There are no available data that evaluated left ventricular dimensions and mass in neonates with symmetric and asymmetric intrauterine growth restriction. Therefore, we...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113002199
更新日期:2015-02-01 00:00:00
abstract::Paediatric heart transplantation has evolved over the last 3 decades. The research group, Pediatric Heart Transplant Study, has been in step with that evolution over the nearly 20 years of its existence by utilising its registry to contribute a wealth of clinical research to the field. The highlights of its studies wi...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951115000931
更新日期:2015-08-01 00:00:00
abstract::Arterial switch surgery for d-transposition of great arteries is usually performed in the first 2 weeks of life before the left ventricle regresses. The arterial switch surgery that helps achieve anatomic and physiologic correction of this condition has better long-term outcomes than other surgical approaches. The pro...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001004
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Obesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors. OBJECTIVE:To determine early markers of left ventricular affection in obese pa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001627
更新日期:2018-01-01 00:00:00
abstract::Tetralogy of Fallot is only rarely associated with aortic valvar disease. We present a child who had uncomplicated repair of tetralogy of Fallot at 16 months of age, and who developed mild aortic stenosis three years later, with mild to moderate aortic incompetence being seen two years subsequent to that event. No aor...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Tracheobronchial compression of cardiovascular origin is an uncommon and frequently unrecognised cause of respiratory distress in children. The compression may be due to encircling vessels or dilated neighbouring cardiovascular structures. Bronchoscopy and detailed radiography, especially computed tomography and magne...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112000765
更新日期:2013-04-01 00:00:00
abstract::Adequate arch augmentation for interrupted aortic arch repair is quite important to avoid post-operative recoarctation and bronchial compression. We describe here two successful cases of aortic arch reconstruction using autologous materials such as a pulmonary artery patch and a reversed left subclavian artery flap in...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113000899
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:There is no standard dose or protocol for beta-blocker administration as preconditioning in children undergoing coronary CT angiography. METHODS:A total of 63 consecutive patients, with a mean age of 10.0±3.1 years, who underwent coronary CT angiography to assess possible coronary complications were enrolle...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111800118X
更新日期:2018-10-01 00:00:00
abstract::The levoatriocardinal vein is the embryological remnant of the connection between the pulmonary and systemic venous systems. It is a rare lesion that usually occurs in the presence of left-sided obstruction, developing as a pathway for decompression of the pulmonary veins. We report the first case of a levoatriocardin...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951116000652
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Tricuspid regurgitation as a manifestation of an isolated congenital anomaly of the tricuspid valve is rare. Cross-sectional and color Doppler echocardiography allow improved evaluation of tricuspid valvar function. As a result, the heterogeneous category of congenital tricuspid valvar dysplasia may be bette...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100004972
更新日期:1999-05-01 00:00:00
abstract::A bicuspid aortic valve is not only a common congenital heart defect but also an enigmatic condition that can cause a large spectrum of diseases, such as aortic valve stenosis and severe heart failure in newborns whereas aortic dissection in adults. On the contrary, a bicuspid aortic valve can also occur with normal f...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951118001658
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The relationship between sildenafil dosing, exposure, and systemic hypotension in infants is incompletely understood. OBJECTIVES:The aim of this study was to characterise the relationship between predicted sildenafil exposure and hypotension in hospitalised infants. METHODS:We extracted information on sild...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001639
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:SCN5A encodes sodium-channel α-subunit Nav1.5. The mutations of SCN5A can lead to hereditary cardiac arrhythmias such as the long-QT syndrome type 3 and Brugada syndrome. Here we sought to identify novel mutations in a family with arrhythmia. METHODS:Genomic DNA was isolated from blood of the proband, who w...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117002980
更新日期:2018-05-01 00:00:00
abstract::Although extrarenal manifestations of haemolytic-uraemic syndrome are not frequent, myocardial dysfunction should be given special consideration because of the importance of proper early haemodynamic management and potential complications. We report the case of a 21-month-old child with haemolytic-uraemic syndrome who...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115002759
更新日期:2016-06-01 00:00:00
abstract::Neonatal aortic thrombosis is a rare occurrence but can be life-threatening. Most aortic thrombosis in neonates is related to umbilical artery catheters. A case of a neonate with a spontaneous aortic thrombosis is described here along with a comprehensive review of the literature for cases of neonatal aortic thrombosi...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951119003093
更新日期:2020-01-01 00:00:00
abstract::We report a left atrial appendage diverticulum in close proximity to the left coronary artery, thereby mimicking a fistulous connection between the two structures. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111400211X
更新日期:2015-03-01 00:00:00
abstract::Valvar heart disease can be complicated by hemodynamic derangements, depending on the degree of the abnormality. Stenosis causes pressure overload of the chamber draining through the valve and regurgitation results in volume overload. Many lesions have a component of both, resulting in both pressure and volume overloa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001978
更新日期:2014-12-01 00:00:00
abstract::A complication is an event or occurrence that is associated with a disease or a healthcare intervention, is a departure from the desired course of events, and may cause, or be associated with, suboptimal outcome. A complication does not necessarily represent a breech in the standard of care that constitutes medical ne...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951108002990
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Efficient diagnosis of an underlying genetic aetiology in a patient with congenital heart disease is essential to optimising clinical care. Copy number variants are one aetiology of congenital heart disease; the majority are identifiable by targeted fluorescence in situ hybridisation or array comparative geno...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001868
更新日期:2015-01-01 00:00:00
abstract::Plastic bronchitis is a severe complication after a Fontan procedure, with an estimated incidence around 1-2% and poor prognosis. We present the cases of four patients with plastic bronchitis after a total cavopulmonary connection with a stenosis of the left pulmonary artery that was stented successfully. In three of ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113002163
更新日期:2015-01-01 00:00:00
abstract::IntroductionChildren with CHD and acquired heart disease have unique, high-risk physiology. They may have a higher risk of adverse tracheal-intubation-associated events, as compared with children with non-cardiac disease.Materials and methodsWe sought to evaluate the occurrence of adverse tracheal-intubation-associate...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951118000495
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of anatomic biventricular repair by a combination of intraatrial and intraventricular re-routing in patients with isomerism of the left atrial appendages. METHODS:Anatomic biventricular repair by means of combined intraratrial and intraventricular re-routing was achieved in 5 of the...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100012361
更新日期:2001-01-01 00:00:00
abstract::Persistent fifth - double-lumen - aortic arch is a rarely seen entity, which is usually associated with other cardiac anomalies; it has been previously reported only in children. We report a new case of double-lumen aortic arch with a systemic-to-systemic connection diagnosed incidentally during cardiac multi-detector...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001855
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:Subclinical hypothyroidism or mild thyroid failure is a common problem in patients without known thyroid disease. METHODS:Demographic and analytical data were collected in 309, of which 181 were male and 128 were female, congenital heart disease (CHD) patients. CHD patients with thyroid-stimulating hormon...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001711
更新日期:2015-08-01 00:00:00
abstract::Decades ago, mass-scale epidemiologic studies were undertaken to accurately describe the prevalence of congenital heart disease and associated malformations, and to identify inheritance patterns, teratogenic influence and aetiologic underpinnings. Despite phenomenal breakthroughs in molecular diagnosis of congenital h...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001698
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to identify incidence, aetiology, and outcomes of extubation failure in infants with shunt-dependent pulmonary blood flow at a single tertiary care, academic children's hospital. The second objective of this study was to determine the haemodynamic effects of transition of positi...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112002181
更新日期:2014-02-01 00:00:00
abstract::A 34-week premature neonate presented with drug-refractory permanent junctional incessant tachycardia and haemodynamic compromise. The patient underwent successful radiofrequency catheter ablation using a single-catheter approach. The child remains in sinus rhythm, without pharmacological treatment, 2 years after the ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112000182
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Diaphragm dysfunction following surgery for congenital heart disease is a known complication leading to delays in recovery and increased post-operative morbidity and mortality. We aimed to determine the incidence of and risk factors associated with diaphragm plication in children undergoing cardiac surgery a...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951119002671
更新日期:2020-01-01 00:00:00
abstract::Disconnection of a pulmonary artery needs early surgical treatment in order to support the growth of the vessel. However, owing to the high rate of re-stenosis after traditional surgical reconstruction, we developed a hybrid approach involving the creation of pulmonary artery continuity by using autologous or heterolo...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118001129
更新日期:2018-11-01 00:00:00