Abstract:
:Fibrates are peroxisome proliferator-activated receptor-α agonists and are clinically used for treatment of dyslipidemia and hypertriglyceridemia. Fenofibrate is reported as a cardioprotective agent in various models of cardiac dysfunction; however, limited literature is available regarding the role of gemfibrozil as a possible cardioprotective agent, especially in a non-obese model of cardiac remodelling. The present study investigated the role of gemfibrozil against partial abdominal aortic constriction-induced cardiac hypertrophy in rats. Cardiac hypertrophy was induced by partial abdominal aortic constriction in rats and they survived for 4 weeks. The cardiac hypertrophy was assessed by measuring left ventricular weight to body weight ratio, left ventricular wall thickness, and protein and collagen content. The oxidative stress in the cardiac tissues was assessed by measuring thiobarbituric acid-reactive substances, superoxide anion generation, and reduced glutathione level. The haematoxylin-eosin and picrosirius red staining was used to observe cardiomyocyte diameter and collagen deposition, respectively. Moreover, serum levels of cholesterol, high-density lipoproteins, triglycerides, and glucose were also measured. Gemfibrozil (30 mg/kg, p.o.) was administered since the first day of partial abdominal aortic constriction and continued for 4 weeks. The partial abdominal aortic constriction-induced cardiac oxidative stress and hypertrophy are indicated by significant change in various parameters used in the present study that were ameliorated with gemfibrozil treatment in rats. No significant change in serum parameters was observed between various groups used in the present study. It is concluded that gemfibrozil ameliorates partial abdominal aortic constriction-induced cardiac oxidative stress and hypertrophy and in rats.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Singh AP,Singh R,Krishan Pdoi
10.1017/S104795111400081Xsubject
Has Abstractpub_date
2015-04-01 00:00:00pages
725-30issue
4eissn
1047-9511issn
1467-1107pii
S104795111400081Xjournal_volume
25pub_type
杂志文章abstract:BACKGROUND:Neonates and infants with congenital and acquired cardiac disease often require placement of central venous lines for extended intravenous therapy. It may be advantageous to avoid the larger venous vessels of the head and neck and lower extremities in order to preserve these for future interventions and ther...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110000090
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To evaluate heart rate variability by Holter monitoring in type 1 diabetic children compared with a healthy control group and determine the factors modifying heart rate variability. METHODS:This was designed as a prospective study comparing 28 patients, diagnosed with type 1 diabetes and under follow-up, wit...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001224
更新日期:2014-10-01 00:00:00
abstract::Improving population-level cardiovascular health is a public health priority. Guided by the American Heart Association's metrics for ideal heart health, we examined the prevalence of behavioural heart health indicators using a representative sample of urban adolescents. Less than 1% (0.6%) of the sample had ideal hear...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001121
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Transcatheter closure of atrial septal defects is performed under fluoroscopy, but echocardiography has gained an important role in the procedure. With the new Amplatzer Septal Occluder a device has become available which is easy to implant with minimal fluoroscopy time. We developed an interventional proced...
journal_title:Cardiology in the young
pub_type: 临床试验,杂志文章
doi:10.1017/s1047951100008349
更新日期:1999-03-01 00:00:00
abstract::Cardiac involvement is a rare complication of infection by the influenza B virus. It usually presents with ventricular dysfunction, arrhythmias, or both. We report a 13-year-old boy with clinical, electrocardiographic, and laboratory findings of myocardial ischaemia during an otherwise silent acute infection with infl...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105000454
更新日期:2005-04-01 00:00:00
abstract::An interarterial course of anomalous left main coronary artery originating from the right aortic coronary sinus of valsalva is a rare condition among anomalous aortic origin of the coronary artery. Various surgical options are available. We performed an alternative procedure, that is, mobilisation of the pulmonic root...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111002113
更新日期:2012-10-01 00:00:00
abstract::Innocent murmurs are common in childhood. They require accurate diagnosis to avoid unnecessary anxiety and/or restrictions. With this in mind, we studied prospectively children diagnosed by a paediatric cardiologist as having innocent murmurs to review the necessity of investigations in excluding organic abnormalities...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s104795110000963x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:Prognosis of the transposition of the great arteries has completely changed since the introduction of the arterial switch. Time limit to perform this intervention is still controversial. The aim of this study is to demonstrate the early and late outcome of primary arterial switch operation beyond the age of m...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120001456
更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION:Infants undergoing stage 1 palliation for hypoplastic left heart syndrome may have post-operative feeding difficulties. Although the cause of feeding difficulties in these patients is multi-factorial, residual arch obstruction may affect gut perfusion, contributing to feeding intolerance. We hypothesised t...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951120000177
更新日期:2020-03-01 00:00:00
abstract::Kawasaki disease constitutes an acute febrile vasculitis of unknown aetiology. It is considered the most common cause of acquired cardiac failure in children. Although standard treatment comprises intravenous immunoglobulin and aspirin, some children exhibit refractory disease, necessitating the use of alternative the...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001260
更新日期:2012-08-01 00:00:00
abstract::We assessed the thickness of the normal left ventricular wall according to gender by performing two-dimensional echocardiography in children. While a few studies have evaluated left ventricular wall thicknesses in children using two-dimensional echocardiography, there is little information related to the influence of ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951102000070
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Efficient diagnosis of an underlying genetic aetiology in a patient with congenital heart disease is essential to optimising clinical care. Copy number variants are one aetiology of congenital heart disease; the majority are identifiable by targeted fluorescence in situ hybridisation or array comparative geno...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001868
更新日期:2015-01-01 00:00:00
abstract::Noonan's syndrome involves the association of multiple congenital abnormalities, with a variety of cardiac defects. We describe here the association of Noonan's syndrome with multiple pulmonary arteriovenous fistulas and bilateral duplicated renal collecting systems. To the best of our knowledge, this is the first rep...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951107000352
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Obesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors. OBJECTIVE:To determine early markers of left ventricular affection in obese pa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001627
更新日期:2018-01-01 00:00:00
abstract::A bicuspid aortic valve is not only a common congenital heart defect but also an enigmatic condition that can cause a large spectrum of diseases, such as aortic valve stenosis and severe heart failure in newborns whereas aortic dissection in adults. On the contrary, a bicuspid aortic valve can also occur with normal f...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951118001658
更新日期:2019-01-01 00:00:00
abstract::It is controversial to observe or close symptomatic congenital coronary artery fistula in infants. We herein describe a medium-sized symptomatic congenital coronary artery fistula that underwent rapid spontaneous closure in an infant aged <3 months. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001127
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:The concept of self-management of oral anticoagulation has been shown to entail better quality of treatment than conventional management when assessed in selected adults. We have extended the concept of self-management to include children with congenital cardiac disease, hypothesizing self-management of oral ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951101000282
更新日期:2001-05-01 00:00:00
abstract::Tetralogy of Fallot is only rarely associated with aortic valvar disease. We present a child who had uncomplicated repair of tetralogy of Fallot at 16 months of age, and who developed mild aortic stenosis three years later, with mild to moderate aortic incompetence being seen two years subsequent to that event. No aor...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::A percutaneous transcatheter balloon dilation of a pulmonary venous pathway obstruction was successfully performed in a 40-year-old patient after a Mustard procedure. During the procedure, real-time three-dimensional trans-oesophageal echocardiography demonstrated the morphology of the obstruction. Our case highlights...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119001045
更新日期:2019-07-01 00:00:00
abstract::Isolated aortic regurgitation and myocardial infarction are a rare congenital defect among neonatal patients. We present a case of a neonate with an unusual aortic valve morphology causing both regurgitation and obstruction of the left coronary artery ostium. Despite both non-invasive and invasive imaging modalities, ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120001377
更新日期:2020-07-01 00:00:00
abstract::Persistent patency of the arterial duct represents one of the most common lesions in the field of congenital cardiac disease. The strategies for management continue to evolve. In this review, we focus on management beyond the neonatal period. We review the temporal evolution of strategies for management, illustrate th...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951107001175
更新日期:2007-09-01 00:00:00
abstract::We describe our experience with 2 patients having Costello syndrome, aged 11 and 36 months, who suffered systolic anterior motion of the aortic leaflet of the mitral valve and obstructive cardiac hypertrophy requiring surgery, comparing their cardiac characteristics to those described previously. We conclude that the ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951109991181
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Catheter interventions for residual lesions in the early postoperative period after CHD operations are still not established as a reliable treatment option. METHODS:We retrospectively reviewed our institutional experience of cardiac catheterisations and catheter interventions performed in the early postoper...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118001452
更新日期:2018-12-01 00:00:00
abstract::We report a case in which a meandering right pulmonary vein connecting to the left atrium is associated with hypoplasia of the right lung, horseshoe lung, abnormal pulmonary lobation, and abnormal branching of the pulmonary arteries. We discuss its relationship to the so-called scimitar variant, and to the scimitar sy...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951106000461
更新日期:2006-06-01 00:00:00
abstract::Innocent murmurs in childhood are common, and often they do not reflect cardiac disease. We have performed a prospective review, by means of a questionnaire, to clarify the parental perception of the innocent murmur identified in their child. Whenever possible, depending on age, we also sought the input of the child. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951102001063
更新日期:2002-12-01 00:00:00
abstract::We report here the case of a 27-year-old woman with Noonan syndrome presenting with ventricular fibrillation. After successful defibrillation, echocardiography revealed hypertrophic cardiomyopathy associated with left ventricular outflow tract obstruction. Normal echocardiographic cardiac structure and function were r...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110001708
更新日期:2011-04-01 00:00:00
abstract::Mitral valve aneurysm not associated with infective endocarditis is rarely reported in children. We report a case of perforated posterior mitral leaflet aneurysm in an infant with reference to surgical and histopathological findings. Although its aetiology remains unclear, we suggest to include mitral valve aneurysm i...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120003340
更新日期:2020-10-19 00:00:00
abstract::This brief report describes a case of flail anterior tricuspid valve leaflet in a neonate associated with maternal antiphospholipid syndrome. Fetal echocardiography at 27 weeks of gestation showed competent atrioventricular valves with biventricular echogenic chordae. Fetal distress was noted at delivery, and echocard...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117000798
更新日期:2017-10-01 00:00:00
abstract::We report the case of a child with cor triatriatum dexter masquerading as Ebstein's anomaly on transthoracic echocardiography. This was attributed to a floppy membrane arising from the right atrium, protruding into the tricuspid valve and pushing the leaflets downwards, giving an impression of Ebstein's anomaly. The i...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111000023
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:At present, the exclusion for percutaneous pulmonary valve implantation for free pulmonary regurgitation after tetralogy of Fallot repair includes an unfavourably large right ventricular outflow tract. OBJECTIVE:To report feasibility and early experience with a recently developed transcatheter heart valve, ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001067
更新日期:2016-04-01 00:00:00