Abstract:
BACKGROUND:Children with congenital cardiac defects may have associated chromosomal anomalies, airway compromise, and/or pulmonary hypertension, which can pose challenges to adequate sedation, weaning from mechanical ventilation, and successful extubation. Propofol, with its unique properties, may be used as a bridge to extubation in certain cardiac populations. MATERIALS AND METHODS:We retrospectively reviewed 0-17-year-old patients admitted to the Cardiac Intensive Care Unit between January, 2007 and September, 2008, who required mechanical ventilation and received a continuous infusion of propofol as a bridge to extubation. Medical charts were reviewed for demographics, associated comorbidities, as well as additional sedation medications and haemodynamic trends including vital signs and vasopressor support during the peri-infusion period. Successful extubation was defined as no re-intubation required for respiratory failure within 48 hours. Outcomes measured were successful extubation, evidence for propofol infusion syndrome, haemodynamic stability, and fluid and inotropic requirements. RESULTS:We included 11 patients for a total of 12 episodes. Propofol dose ranged from 0.4 to 5.6 milligram per kilogram per hour with an average infusion duration of 7 hours. All patients were successfully extubated, and none demonstrated worsening metabolic acidosis suggestive of the propofol infusion syndrome. All patients remained haemodynamically stable during the infusion with average heart rates and blood pressures remaining within age-appropriate ranges. One patient received additional fluid but no increase in vasopressors was needed. CONCLUSIONS:This study suggests that propofol infusions may allow for successful extubation in a certain population of children with congenital cardiac disease. Further studies are required to confirm whether propofol is an efficient and safe alternative in this setting.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Teng SN,Kaufman J,Czaja AS,Friesen RH,da Cruz EMdoi
10.1017/S1047951110001344subject
Has Abstractpub_date
2011-02-01 00:00:00pages
46-51issue
1eissn
1047-9511issn
1467-1107pii
S1047951110001344journal_volume
21pub_type
杂志文章abstract::Cognitive, functional, educational achievement and behavioural measures were employed to assess neurobehavioral status in 57 of 60 participants who were initially enrolled in the Baltimore-Washington Infant Study, and who survived surgical correction of complete transposition (concordant atrioventricular and discordan...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/s1047951100006867
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Right heart function is an important predictor of morbidity and mortality in pulmonary arterial hypertension and many CHD. We investigated whether treatment with the prostacyclin analogue treprostinil could prevent pressure overload-induced right ventricular hypertrophy and failure. METHODS:Male Wistar rats...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951116000160
更新日期:2017-01-01 00:00:00
abstract::VACTERL association and Scimitar syndrome are rare congenital diseases. In this study, we report on a neonate with prenatal suspicion of VACTERL association and small left-sided cardiac structures, which, only on postnatal angiography, could be revealed to be part of a Scimitar syndrome. As this is the second reported...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114000924
更新日期:2015-03-01 00:00:00
abstract::Congenital complete tracheal rings are usually associated with pulmonary slings. We report a rare association of congenital complete tracheal rings with hypoplastic left heart variant. A term infant with diagnosis of a mildly hypoplastic mitral valve, unicuspid aortic valve, and moderately hypoplastic aortic arch with...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118002391
更新日期:2019-03-01 00:00:00
abstract::Large volumes of data and multiple computing platforms are now universal components of paediatric cardiovascular medicine, but are in a constant state of evolution. Often, multiple sets of related data reside in disconnected "silos", resulting in clinical, administrative, and research activities that may be duplicativ...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951116001268
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD. STUDY DESIGN:A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120000785
更新日期:2020-05-01 00:00:00
abstract::An unusual combination of three types of interatrial communications - coronary sinus defect, primum defect, and secundum defect - occurring together in a 3-year-old child is presented. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795112000400X
更新日期:2020-12-01 00:00:00
abstract::A two-year-old boy with a background history of Down syndrome and partial atrioventricular septal defect presented with acute respiratory distress requiring intubation and mechanical ventilation. He continued to deteriorate, despite ventilation; direct laryngoscopy, bronchoscopy, and computed tomography demonstrated s...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114000468
更新日期:2015-03-01 00:00:00
abstract::Arterial switch surgery for d-transposition of great arteries is usually performed in the first 2 weeks of life before the left ventricle regresses. The arterial switch surgery that helps achieve anatomic and physiologic correction of this condition has better long-term outcomes than other surgical approaches. The pro...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001004
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Diaphragm dysfunction following surgery for congenital heart disease is a known complication leading to delays in recovery and increased post-operative morbidity and mortality. We aimed to determine the incidence of and risk factors associated with diaphragm plication in children undergoing cardiac surgery a...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951119002671
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Parental suspicions that the child may possibly take narcotics may be substantiated by hair analysis, which may not only identify the narcotic abuse profile, but also define the minimum period of narcotic usage. OBJECTIVE:A toxicological hair analysis aiming at detecting the presence of amphetamines and can...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111000667
更新日期:2012-02-01 00:00:00
abstract::A neonate with transposition of the great arteries and intact ventricular septum presented without pulmonary over-circulation, and subsequently developed pulmonary haemorrhage after corrective surgery. Postoperative CT revealed an aortopulmonary collateral artery arising from the descending aorta, and we performed suc...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001328
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Disagreement currently exists regarding the definition of aortic dextroposition. It is suggested that the term be used interchangeably with aortic overriding, along with suggestions that the aortic valve overrides in the normal heart. The dextroposed aorta, however, does not always override the crest of the ...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951114001139
更新日期:2015-04-01 00:00:00
abstract::A 9-month-old infant presented with fever, dyspnoea, and a murmur. Echocardiography showed a mitral vegetation with significant regurgitation. Mitral valve plasty was performed on day 6, and was polymerase chain reaction positive for Kingella kingae. The cardiac outcome was favourable. This case illustrates a subtle p...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110000351
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:It is accepted treatment to give vasopressin to adults in postcardiotomy shock, but such use in children is controversial. Cardiopulmonary bypass is presumed to attenuate the normal endogenous vasopressin response to shock. We hypothesized that levels of vasopressin in children are altered by bypass, and tha...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951108001881
更新日期:2008-04-01 00:00:00
abstract::A 29-year-old gravida1 para1 woman presented with increasing fatigue. Multi-modality imaging demonstrated the left coronary artery arising from the main pulmonary artery with large collateral vessels in the interventricular septum, in keeping with unrepaired anomalous left coronary artery from the pulmonary artery. Ca...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117000932
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To describe endovascular stent placement using partially covered stents to preserve flow in head and neck vessels. BACKGROUND:Endovascular stent placement has become established as a first-line therapy for native coarctation of the aorta or re-coarctation in older children and adults. Increasingly covered st...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112000236
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:This study aimed to examine the differences between arterial and inferior caval vein oxygen saturation, fractional oxygen extraction, and the shunt index, which were calculated in the diagnosis of patent ductus arteriosus. METHODS:Twenty-seven preterm infants were included in this study and were divided int...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113000772
更新日期:2014-08-01 00:00:00
abstract::Most patients with the Mustard procedure are now adults. To date, however, there have been few reports on resting and exercise hemodynamics in a large population of adults with this circulation. The aim of this study is to describe such parameters in one of the largest and oldest populations of adults with the Mustard...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s104795110100052x
更新日期:2001-07-01 00:00:00
abstract::Ascending aortic pseudoaneurysms are a rare complication following cardiac surgery. Their traditional surgical management carries high morbidity and mortality, especially in patients with multiple comorbidities. Transcatheter closure of these pseudoaneurysms using a septal occluder device has been previously reported ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001170
更新日期:2014-08-01 00:00:00
abstract::Endothelial dysfunction has been reported in hypoxaemic patients with the Eisenmenger syndrome, but a direct correlation between levels of endothelial markers and the severity of hypoxaemia has not been explored. With this in mind, we compared the levels in the plasma of tissue-type plasminogen activator, thrombomodul...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105001381
更新日期:2005-10-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951102000793
更新日期:2002-10-01 00:00:00
abstract::Approximately 32,000 infants are born with CHDs each year in the United States of America. Of every 1000 live births, 2.3 require surgical or transcatheter intervention in the first year of life. There are few more stressful times for parents than when their neonate receives a diagnosis of complex CHD requiring surger...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1017/S1047951118000604
更新日期:2018-07-01 00:00:00
abstract::Our long-term follow-up has revealed that symmetrical development of the breasts is significantly impaired in pre-pubescent female patients subsequent to an anterolateral thoracotomy. Although standard posterolateral and anterolateral right-sided thoracotomies are used for correction of "simple" cardiac lesions such a...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Adequate arch augmentation for interrupted aortic arch repair is quite important to avoid post-operative recoarctation and bronchial compression. We describe here two successful cases of aortic arch reconstruction using autologous materials such as a pulmonary artery patch and a reversed left subclavian artery flap in...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113000899
更新日期:2014-06-01 00:00:00
abstract::Neonates and small infants have unique characteristics that make it possible to obtain echocardiographic views that are inaccessible in older patients. A high transsternal approach through the cartilaginous sternum and the thymus gland allows visualisation of a short-axis view of the pulmonary valve. This view should ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001845
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to demonstrate the safety and feasibility of using the new Cardia Ultrasept II™ device with interposed Goretex patch referring to the perforation of polyvinyl alcohol membrane. BACKGROUND:Great advances have been made in the development of devices for closure of atrial septal...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951118000100
更新日期:2018-05-01 00:00:00
abstract::Information about acute coronary syndrome caused by Kawasaki disease-related coronary artery lesions in adults is sketchy. We reviewed the clinical features of 50 adult patients who had an acute coronary syndrome caused by coronary artery lesions due to Kawasaki disease or probable Kawasaki disease from 1980 to 2008. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110001502
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Adverse influences arising in fetal life or immediately after birth have a permanent effect on body structure, physiology and metabolism. Evidence is now accumulating that programming of bone growth might be an important contributor to the later risk of osteoporosis. Long-term morbidity and mortality associa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951102000963
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:To describe the echocardiographic features, underlying causes, and outcome of fetuses with dilated cardiomyopathy. DESIGN:A retrospective observational study between 1983 and 2003 at a tertiary centre for fetal cardiology. PATIENTS:Affected fetuses were identified using a computerised database. We included...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105000855
更新日期:2005-08-01 00:00:00