Abstract:
BACKGROUND:Right heart function is an important predictor of morbidity and mortality in pulmonary arterial hypertension and many CHD. We investigated whether treatment with the prostacyclin analogue treprostinil could prevent pressure overload-induced right ventricular hypertrophy and failure. METHODS:Male Wistar rats were randomised to severe pulmonary trunk banding with a 0.5-mm banding clip (n=41), moderate pulmonary trunk banding with a 0.6-mm banding clip (n=36), or sham procedure (n=10). The banded rats were randomised to 6 weeks of treatment with a moderate dose of treprostinil (300 ng/kg/minute), a high dose of treprostinil (900 ng/kg/minute), or vehicle. RESULTS:Pulmonary trunk banding effectively induced hypertrophy, dilatation, and decreased right ventricular function. The severely banded animals presented with decompensated heart failure with extracardial manifestations. Treatment with treprostinil neither reduced right ventricular hypertrophy nor improved right ventricular function. CONCLUSIONS:In the pulmonary trunk banding model of pressure overload-induced right ventricular hypertrophy and failure, moderate- and high-dose treatment with treprostinil did not improve right ventricular function neither in compensated nor in decompensated right heart failure.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Axelgaard S,Holmboe S,Ringgaard S,Hillgaard TK,Andersen S,Hansen MS,Andersen A,Nielsen-Kudsk JEdoi
10.1017/S1047951116000160subject
Has Abstractpub_date
2017-01-01 00:00:00pages
90-100issue
1eissn
1047-9511issn
1467-1107pii
S1047951116000160journal_volume
27pub_type
杂志文章abstract::We report a case where fetal echocardiography identified both complete heart block and ventricular tachycardia. The mother tested positive for anti-Ro antibodies. Prenatal detection of this unusual combination of arrhythmias prompted early postnatal evaluation, which revealed prolongation of the QT interval. Autoimmun...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105000673
更新日期:2005-06-01 00:00:00
abstract:INTRODUCTION:Although chylothorax is an uncommon complication following paediatric cardiothoracic surgery, it has significant associated morbidities and increased in-hospital mortality, as well as results in higher costs. A lack of prospective evidence or consensus guidelines for management of chylothorax further hinde...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951119001525
更新日期:2019-09-01 00:00:00
abstract::Infective endocarditis is a microbial infection of the endothelial surface of the heart, predominantly the heart valves, that is associated with high mortality and morbidity. Few contemporary data exist regarding affected children in our context. AIMS AND OBJECTIVES:We aimed to describe the profile and treatment outc...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951119002154
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:The management of fluid overload after congenital heart surgery has been limited to diuretics, fluid restriction, and dialysis. This study was conducted to determine the association between peritoneal dialysis and important clinical outcomes in children undergoing congenital heart surgery. METHODS:A retrosp...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951120000141
更新日期:2020-04-01 00:00:00
abstract::Atrioventricular valve regurgitation is widely known as a risk factor for Fontan completion in patients with univentricular physiology. To date, indications and timing for atrioventricular valve repair remain unclear and different surgical techniques have been advocated. Since 2013, 50 consecutive patients underwent e...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114002352
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Kawasaki disease, which is characterised by systemic vasculitides accompanied by acute fever, is regularly treated by intravenous immunoglobulin to avoid lesion formation in the coronary artery; however, the mechanism of intravenous immunoglobulin therapy is unclear. Hence, we aimed to analyse the global exp...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001433
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Holt-Oram syndrome is characterised by CHD and limb anomalies. Mutations in TBX5 gene, encoding the T-box transcription factor, are responsible for the development of Holt-Oram syndrome, but such mutations are variably detected in 30-75% of patients. METHODS:Clinically diagnosed eight Holt-Oram syndrome pat...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001656
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:In very low birth weight infants, persistence of a patent ductus arteriosus results in morbidity and mortality. Therapies to close the ductus are effective, but clinical outcomes may depend on the accuracy of diagnosis and the timing of administration. The objective of the present study was to characterise t...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001081
更新日期:2017-11-01 00:00:00
abstract::Sudden cardiac death is a rare but socially devastating event. The most common causes of sudden cardiac death are congenital electrical disorders and structural heart diseases. The majority of these diseases have an incomplete penetrance and variable expression; therefore, patients may be unaware of their illness. In ...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951112001138
更新日期:2013-04-01 00:00:00
abstract::The interest of professional medical societies in research about outcomes, mixed with the recent accessibility to management of data on the internet, has moved many societies to create national databases or registries for their specialty. In societies with procedure-based specialties such as surgery, these databases w...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951108002916
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD. STUDY DESIGN:A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120000785
更新日期:2020-05-01 00:00:00
abstract:AIMS:To assess results of closure of atrial septal defects within the oval fossa by devices delivered by catheterisation in symptomatic infants and children under 2 years of age. METHODS AND RESULTS:The Amplatzer septal occluder was used. Results, and complications of transcatheter device treatment in patients aged be...
journal_title:Cardiology in the young
pub_type: 临床试验,杂志文章
doi:10.1017/s1047951100008234
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Care of children with functionally univentricular hearts is resource-intensive. OBJECTIVES:To analyse pregnancy and early post-natal outcomes of fetuses with functionally univentricular hearts in the setting of a low-middle-income country. METHODS:A retrospective study was conducted during the period of Ja...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120002929
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Complications at the vascular access sites are among the most common adverse events in congenital cardiac catheterization. The use of small-gauge catheters may reduce these events; however, other factors can contribute to the development of vascular complications. OBJECTIVES:To determine factors associated ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111000989
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to report on the short-term and mid-term outcomes of preterm infants who underwent patent ductus arteriosus ligation through anterior mini-thoracotomy. METHODS:Data for 103 preterm infants who underwent patent ductus arteriosus clipping through an anterior mini-thoracotomy at the 2nd...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951121000032
更新日期:2021-01-28 00:00:00
abstract:AIM:We aimed to investigate the role of adiponectin in acute rheumatic fever by evaluating correlations with cytokines and acute-phase reactants. METHODS:Patients were divided into three groups by clinical findings. Group 1 included 8 patients with only chorea, Group 2 included 13 patients with arthritis and carditis,...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001012
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:CHDs form a complex and heterogeneous group of clinical entities, with high morbidity and mortality. With the advancement of surgical and invasive techniques and clinical treatment, the survival of these patients has increased significantly, and there are reports of a high prevalence of ocular abnormalities ...
journal_title:Cardiology in the young
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S104795111500044X
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To examine the clinical utility of the Pediatric Symptom Checklist 17 for identifying psychosocial concerns and improving access to psychology services within a paediatric cardiology clinic. METHOD:Parents of 561 children (aged 4-17 years) presenting for follow-up of CHD, acquired heart disease, or arrhythmi...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001900
更新日期:2016-08-01 00:00:00
abstract::A number of microorganisms were hypothesised as an aetiology of the Kawasaki disease. Unfortunately, no specific agent that provides reproducible evidence has yet been reported. We report two cases of extremely rare Kawasaki disease with tsutsugamushi disease. These case reports suggest that Kawasaki disease can rarel...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120000931
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The association between long QT interval and sudden infant death syndrome has been clearly established. Several studies have been conducted to determine the evolution of the QT interval in childhood from birth, but only in full-term newborns. However, data on the QT interval in pre-term infants are extremely...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001958
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Assessment of right ventricular size and function is an important part of the clinical cardiac evaluation; however, these quantitative measures are challenging by echocardiography. Automated software could be useful in place of manual measurements and qualitative assessment. This study evaluates a semi-autom...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119001641
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:To evaluate long-term outcome of initial aortic valve intervention in a paediatric population with congenital aortic stenosis, and to determine risk factors associated with reintervention. PATIENTS AND METHODS:From 1985 to 2009, 77 patients with congenital aortic stenosis and a mean age of 5.8±5.6 years at ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001085
更新日期:2015-06-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/s1047951102000410
更新日期:2002-03-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951104002033
更新日期:2004-04-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951108001881
更新日期:2008-04-01 00:00:00
abstract::Body mass index, race/ethnicity, and payer status are associated with operative mortality in congenital heart disease (CHD). Interactions between these predictors and impacts on longer term outcomes are less well understood. We studied the effect of body mass index, race/ethnicity, and payer on 1-year outcomes followi...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120003911
更新日期:2020-11-19 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001213
更新日期:2016-02-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章
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更新日期:2020-11-10 00:00:00
abstract::We describe a patient with the rare association of the heart in the left chest, congenitally corrected transposition, pulmonary atresia and an intact ventricular septum. There were associated fistulous communications between the morphologically left ventricle and the coronary arteries. Diagnosis was made by echocardio...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100009227
更新日期:2000-05-01 00:00:00