Abstract：
:The abundance of intrinsic disorder in the protein realm and its role in a variety of physiological and pathological cellular events have strengthened the interest of the scientific community in understanding the structural and dynamical properties of intrinsically disordered proteins (IDPs) and regions (IDRs). Attempts at rationalizing the general principles underlying both conformational properties and transitions of IDPs/IDRs must consider the abundance of charged residues (Asp, Glu, Lys, and Arg) that typifies these proteins, rendering them assimilable to polyampholytes or polyelectrolytes. Their conformation strongly depends on both the charge density and distribution along the sequence (i.e., charge decoration) as highlighted by recent experimental and theoretical studies that have introduced novel descriptors. Published experimental data are revisited herein in the frame of this formalism, in a new and possibly unitary perspective. The physicochemical properties most directly affected by charge density and distribution are compaction and solubility, which can be described in a relatively simplified way by tools of polymer physics. Dissecting factors controlling such properties could contribute to better understanding complex biological phenomena, such as fibrillation and phase separation. Furthermore, this knowledge is expected to have enormous practical implications for the design, synthesis, and exploitation of bio-derived materials and the control of natural biological processes.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Bianchi G,Longhi S,Grandori R,Brocca Sdoi
10.3390/ijms21176208subject
Has Abstractpub_date
2020-08-27 00:00:00issue
17issn
1422-0067pii
ijms21176208journal_volume
21pub_type
杂志文章,评审abstract：:Catalytic decomposition of sucrose by acid invertases (AINVs) under acidic conditions plays an important role in the development of sink organs in plants. To reveal the function of AINVs in the development of pepper fruits, nine AINV genes of pepper were identified. Protein sequencing and phylogenetic analysis reveale...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2018-12-20 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-07-13 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-04-17 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-08-02 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2021-01-14 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-10-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-12-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-11-26 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-03-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060890
更新日期：2016-06-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2021-01-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112666
更新日期：2019-05-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249543
更新日期：2020-12-15 00:00:00
abstract：:Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epithelial stem cells ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-10-19 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020320
更新日期：2017-02-03 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-10-31 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-04-17 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-08-31 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2016-07-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17091579
更新日期：2016-09-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2014-02-19 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031010
更新日期：2020-02-04 00:00:00
abstract：:Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18081809
更新日期：2017-08-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092537
更新日期：2018-08-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194874
更新日期：2019-09-30 00:00:00
abstract：:Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21113965
更新日期：2020-05-31 00:00:00
