Abstract:
Importance:Ocular manifestations and outcomes in children with confirmed coronavirus disease 2019 (COVID-19), relevant affecting factors, and differences in ocular disease between children and adults have yet to be fully understood. Objective:To investigate ocular manifestations and clinical characteristics of children with laboratory-confirmed COVID-19. Design, Setting, and Participants:This cross-sectional study was conducted at Wuhan Children's Hospital in Wuhan, China. Children with COVID-19 confirmed by severe acute respiratory syndrome coronavirus disease 2 nucleic acid tests of upper respiratory tract specimens between January 26 and March 18, 2020, were included. Main Outcomes and Measures:Onset clinical symptoms and duration, ocular symptoms, and needs for medication. Results:A total of 216 pediatric patients were included, among whom 134 (62%) were boys, with a median (interquartile range) age of 7.25 (2.6-11.6) years. Based on the exposure history, 193 children (89.4%) had a confirmed (173 [80.1%]) or suspected (20 [9.3%]) family member with COVID-19 infection. The most common symptoms among symptomatic children were fever (81 [37.5%]) and cough (79 [36.6%]). Of 216 children, 93 (43.1%) had no systemic or respiratory symptoms. All children with mild (101 [46.8%]) or moderate (115 [53.2%]) symptoms recovered without reported death. Forty-nine children (22.7%) showed various ocular manifestations, of which 9 had ocular complaints being the initial manifestations of COVID-19. The common ocular manifestations were conjunctival discharge (27 [55.1%]), eye rubbing (19 [38.8%]), and conjunctival congestion (5 [10.2%]). Children with systemic symptoms (29.3% vs 14.0%; difference, 15.3%; 95% CI, 9.8%-20.7%; P = .008) or with cough (31.6% vs 17.5%; difference, 14.1%; 95% CI, 8.0%-20.3%; P = .02) were more likely to develop ocular symptoms. Ocular symptoms were typically mild, and children recovered or improved. Conclusions and Relevance:In this cross-sectional study, children hospitalized with COVID-19 in Wuhan, China, presented with a series of onset symptoms including fever, cough, and ocular manifestations, such as conjunctival discharge, eye rubbing, and conjunctival congestion. Patients' systemic clinical symptoms or cough were associated with ocular symptoms. Ocular symptoms recovered or improved eventually.
journal_name
JAMA Ophthalmoljournal_title
JAMA ophthalmologyauthors
Ma N,Li P,Wang X,Yu Y,Tan X,Chen P,Li S,Jiang Fdoi
10.1001/jamaophthalmol.2020.3690subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1079-1086issue
10eissn
2168-6165issn
2168-6173pii
2769877journal_volume
138pub_type
杂志文章abstract:Importance:Early detection of choroidal melanoma at a small tumor size is emphasized in the literature. However, there is little published information on the specific risks of plaque-irradiated small choroidal melanoma on visual acuity and metastasis. Objective:To analyze outcomes of plaque radiotherapy for small chor...
journal_title:JAMA ophthalmology
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
abstract:Importance:Adding a laser-induced chorioretinal anastomosis (L-CRA) to current treatments for central retinal vein occlusion (CRVO) may improve outcomes and lessen therapy burdens. Objective:To determine the 2-year efficacy of intravitreal ranibizumab with an L-CRA vs ranibizumab alone for patients with macular edema ...
journal_title:JAMA ophthalmology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-12-01 00:00:00
abstract:IMPORTANCE:The presence of choroidal hyperreflective foci in Stargardt disease is, to our knowledge, a potentially new finding. Evaluation of these foci may aid in better understanding of the disease process. OBJECTIVES:To report the presence of choroidal hyperreflective foci in spectral-domain optical coherence tomog...
journal_title:JAMA ophthalmology
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journal_title:JAMA ophthalmology
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-10-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamaophthalmol.2013.323
更新日期:2013-10-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1001/jamaophthalmol.2018.0813
更新日期:2018-06-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2018.5520
更新日期:2019-02-01 00:00:00
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更新日期:2013-08-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-02-01 00:00:00
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2019.2427
更新日期:2019-07-18 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1001/jamaophthalmol.2015.1823
更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2014.358
更新日期:2014-06-01 00:00:00
abstract:IMPORTANCE:We present a method to reintroduce ophthalmic training into the medical school curriculum. OBJECTIVES:To evaluate knowledge and skills acquired when participating in a service project, the Community Vision Project, and to develop a quantitative method for testing skills with the direct ophthalmoscope in pat...
journal_title:JAMA ophthalmology
pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2013.6671
更新日期:2014-03-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1001/jamaophthalmol.2013.5636
更新日期:2014-02-01 00:00:00
abstract:Importance:Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear. Objective:To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma. Design, Setting, and Participants:This case series study was a retrospective medical record...
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更新日期:2019-02-01 00:00:00
abstract:Importance:Mobility limitations arising from vision impairment (VI) can result in loss of independence and reduced quality of life. However, few data are available on the association between VI and mobility limitations at a population-based level, particularly in Asian populations. Objective:To assess the association ...
journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2018-05-01 00:00:00
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更新日期:2013-12-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-08-01 00:00:00
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2018.0846
更新日期:2018-06-01 00:00:00
abstract:Importance:The 2-year efficacy and safety of combination therapy of ranibizumab administered together with verteporfin photodynamic therapy (vPDT) compared with ranibizumab monotherapy in participants with polypoidal choroidal vasculopathy (PCV) are unclear. Objective:To compare treatment outcomes of ranibizumab, 0.5 ...
journal_title:JAMA ophthalmology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-17 00:00:00
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更新日期:2019-05-30 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00