Function of S-adenosylmethionine in germinating yeast ascospores.

Abstract:

:Germination and outgrowth of ascospores of Saccharomyces cerevisiae 4579 require both methionine and adenine, whereas leucine is only required for outgrowth. The methionine requirement may be satisfied by S-adenosylmethionine, but this sulfonium compound will not substitute for adenine. Between 30 and 70 min of protein synthesis is initially required for the completion of germination in strain 4579. The inhibition of S-adenosylmethionine synthetase by trifluoromethionine prevents both germination and protein synthesis. During the initial stages of germination, the S-adenosylmethionine synthetase, S-adenosylmethionine decarboxylase, and transfer ribonucleic acid methyltransferases increased significantly, indicating that polyamines and/or the methylation of transfer ribonucleic acid are required for the initiation of germination.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Choih SJ,Ferro AJ,Shapiro SK

doi

10.1128/JB.131.1.63-68.1977

subject

Has Abstract

pub_date

1977-07-01 00:00:00

pages

63-8

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

131

pub_type

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