A game-theoretic model of Monkeypox to assess vaccination strategies.

Abstract:

:Monkeypox (MPX) is a zoonotic disease similar to smallpox. Its fatality rate is about 11% and it is endemic to the Central and West African countries. In this paper, we analyze a compartmental model of MPX dynamics. Our goal is to see whether MPX can be controlled and eradicated by voluntary vaccinations. We show that there are three equilibria-disease free, fully endemic and previously neglected semi-endemic (with disease existing only among humans). The existence of semi-endemic equilibrium has severe implications should the MPX virus mutate to increased viral fitness in humans. We find that MPX is controllable and can be eradicated in a semi-endemic equilibrium by vaccination. However, in a fully endemic equilibrium, MPX cannot be eradicated by vaccination alone.

journal_name

PeerJ

journal_title

PeerJ

authors

Bankuru SV,Kossol S,Hou W,Mahmoudi P,Rychtář J,Taylor D

doi

10.7717/peerj.9272

subject

Has Abstract

pub_date

2020-06-22 00:00:00

pages

e9272

issn

2167-8359

pii

9272

journal_volume

8

pub_type

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